Non-Ionizing Millimeter Waves Non-Thermal Radiation of Saccharomyces cerevisiae—Insights and Interactions

Barbora, Ayan; Rajput, Shailendra; Komoshvili, Konstantin; Levitan, Jacob; Yahalom, Asher; Liberman-Aronov, Stella

doi:10.3390/app11146635

Title: Non-Ionizing Millimeter Waves Non-Thermal Radiation of Saccharomyces cerevisiae—Insights and Interactions

Journal Article · Tue Jul 20 00:00:00 EDT 2021 · Applied Sciences

DOI:https://doi.org/10.3390/app11146635· OSTI ID:1818863

Barbora, Ayan ^[1]; Rajput, Shailendra ^[1]; Komoshvili, Konstantin ^[1];

^[1];

^[2];

^[1]

Ariel Univ. (Israel)
Ariel Univ. (Israel); Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States)

Non-ionizing millimeter-waves (MMW) interact with cells in a variety of ways. Here the inhibited cell division effect was investigated using 85–105 GHz MMW irradiation within the International Commission on Non-Ionizing Radiation Protection (ICNIRP) non-thermal 20 mW/cm² safety standards. Irradiation using a power density of about 1.0 mW/cm² SAR over 5–6 h on 50 cells/μL samples of Saccharomyces cerevisiae model organism resulted in 62% growth rate reduction compared to the control (sham). The effect was specific for 85–105 GHz range and was energy- and cell density-dependent. Irradiation of wild type and Δrad52 (DNA damage repair gene) deleted cells presented no differences of colony growth profiles indicating non-thermal MMW treatment does not cause permanent genetic alterations. Dose versus response relations studied using a standard horn antenna (~1.0 mW/cm²) and compared to that of a compact waveguide (17.17 mW/cm²) for increased power delivery resulted in complete termination of cell division via non-thermal processes supported by temperature rise measurements. We have shown that non-thermal MMW radiation has potential for future use in treatment of yeast related diseases and other targeted biomedical outcomes.

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Research Organization:: Ariel Univ. (Israel)

Sponsoring Organization:: Israeli Council for Higher Education (CHE)

OSTI ID:: 1818863

Journal Information:: Applied Sciences, Vol. 11, Issue 14; ISSN 2076-3417

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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