Quantitative principles of cis-translational control by general mRNA sequence features in eukaryotes
Journal Article
·
· Genome Biology (Online)
- University of California, Los Angeles, CA (United States). Department of Statistics, Department of Biomathematics, and Department of Human Genetics
- Fred Hutchinson Cancer Research Center, Seattle, WA (United States). Computational Biology Program, Public Health Sciences and Basic Sciences Division
- Lawrence Berkeley National Laboratory, Berkeley, CA (United States). Biological Systems and Engineering Division
General translational cis-elements are present in the mRNAs of all genes and affect the recruitment, assembly, and progress of preinitiation complexes and the ribosome under many physiological states. These elements include mRNA folding, upstream open reading frames, specific nucleotides flanking the initiating AUG codon, protein coding sequence length, and codon usage. The quantitative contributions of these sequence features and how and why they coordinate to control translation rates are not well understood.
- Research Organization:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE
- Grant/Contract Number:
- AC02-05CH11231
- OSTI ID:
- 1626948
- Journal Information:
- Genome Biology (Online), Vol. 20, Issue 1; ISSN 1474-760X
- Publisher:
- BioMed CentralCopyright Statement
- Country of Publication:
- United States
- Language:
- English
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