On the functions of the h subunit of eukaryotic initiation factor 3 in late stages of translation initiation

Kim, Byung-Hoon; Cai, Xue; Vaughn, Justin N.; von Arnim, Albrecht G.

doi:10.1186/gb-2007-8-4-r60

Title: On the functions of the h subunit of eukaryotic initiation factor 3 in late stages of translation initiation

Journal Article · Tue Apr 17 00:00:00 EDT 2007 · GenomeBiology.com

DOI:https://doi.org/10.1186/gb-2007-8-4-r60· OSTI ID:1626719

Kim, Byung-Hoon ^[1]; Cai, Xue ^[2]; Vaughn, Justin N. ^[1]; von Arnim, Albrecht G. ^[1]

Univ. of Tennessee, Knoxville, TN (United States). Dept. of Biochemistry, Cellular and Molecular Biology
Univ. of Tennessee, Knoxville, TN (United States). Dept. of Biochemistry, Cellular and Molecular Biology; Univ. of Oklahoma, Oklahoma City, OK (United States). Health Sciences Center. Dept. of Cell Biology

Background: The eukaryotic translation initiation factor 3 (eIF3) has multiple roles during the initiation of translation of cytoplasmic mRNAs. How individual subunits of eIF3 contribute to the translation of specific mRNAs remains poorly understood, however. This is true in particular for those subunits that are not conserved in budding yeast, such as eIF3h. Results: Working with stable reporter transgenes in Arabidopsis thaliana mutants, it was demonstrated that the h subunit of eIF3 contributes to the efficient translation initiation of mRNAs harboring upstream open reading frames (uORFs) in their 5' leader sequence. uORFs, which can function as devices for translational regulation, are present in over 30% of Arabidopsis mRNAs, and are enriched among mRNAs for transcriptional regulators and protein modifying enzymes. Microarray comparisons of polysome loading in wild-type and eif3h mutant seedlings revealed that eIF3h generally helps to maintain efficient polysome loading of mRNAs harboring multiple uORFs. In addition, however, eIF3h also boosted the polysome loading of mRNAs with long leaders or coding sequences. Moreover, the relative polysome loading of certain functional groups of mRNAs, including ribosomal proteins, was actually increased in the eif3h mutant, suggesting that regulons of translational control can be revealed by mutations in generic translation initiation factors. Conclusion: The intact eIF3h protein contributes to efficient translation initiation on 5' leader sequences harboring multiple uORFs, although mRNA features independent of uORFs are also implicated.

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Research Organization:: Univ. of Tennessee, Knoxville, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: FG02-96ER20223

OSTI ID:: 1626719

Journal Information:: GenomeBiology.com, Vol. 8, Issue 4; ISSN 1465-6906

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
Biotechnology & applied microbiology
genetics & heredity
translation initiation
additional data file
leader sequence
translation state
upstream open reading frame

Title: On the functions of the h subunit of eukaryotic initiation factor 3 in late stages of translation initiation

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