The Hypocrea jecorina (Trichoderma reesei) hypercellulolytic mutant RUT C30 lacks a 85 kb (29 gene-encoding) region of the wild-type genome

Seidl, Verena; Gamauf, Christian; Druzhinina, Irina S.; Seiboth, Bernhard; Hartl, Lukas; Kubicek, Christian P.

doi:10.1186/1471-2164-9-327

Title: The Hypocrea jecorina (Trichoderma reesei) hypercellulolytic mutant RUT C30 lacks a 85 kb (29 gene-encoding) region of the wild-type genome

Journal Article · Fri Jul 11 00:00:00 EDT 2008 · BMC Genomics

DOI:https://doi.org/10.1186/1471-2164-9-327· OSTI ID:1626467

Seidl, Verena ^[1]; Gamauf, Christian ^[1]; Druzhinina, Irina S. ^[1]; Seiboth, Bernhard ^[1]; Hartl, Lukas ^[1]; Kubicek, Christian P. ^[1]

Vienna Univ. of Technology (Austria). Inst. of Chemical Engineering, Research Area Gene Technology and Applied Biochemistry

Background: The hypercellulolytic mutant Hypocrea jecorina (anamorph Trichoderma reesei) RUT C30 is the H. jecorina strain most frequently used for cellulase fermentations and has also often been employed for basic research on cellulase regulation. This strain has been reported to contain a truncated carbon catabolite repressor gene cre1 and is consequently carbon catabolite derepressed. To date this and an additional frame-shift mutation in the glycoprotein-processing βglucosidase II encoding gene are the only known genetic differences in strain RUT C30. Results: In the present paper we show that H. jecorina RUT C30 lacks an 85 kb genomic fragment, and consequently misses additional 29 genes comprising transcription factors, enzymes of the primary metabolism and transport proteins. This loss is already present in the ancestor of RUT C30 – NG 14 – and seems to have occurred in a palindromic AT-rich repeat (PATRR) typically inducing chromosomal translocations, and is not linked to the cre1 locus. The mutation of the cre1 locus has specifically occurred in RUT C30. Some of the genes that are lacking in RUT C30 could be correlated with pronounced alterations in its phenotype, such as poor growth on α-linked oligoand polyglucosides (loss of maltose permease), or disturbance of osmotic homeostasis. Conclusion: Our data place a general caveat on the use of H. jecorina RUT C30 for further basic research.

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Research Organization:: Vienna Univ. of Technology (Austria). Institute of Chemical Engineering

Sponsoring Organization:: USDOE; Austrian Science Foundation (FWF)

Grant/Contract Number:: FWF P-19143; FWF P-19421

OSTI ID:: 1626467

Journal Information:: BMC Genomics, Vol. 9, Issue 1; ISSN 1471-2164

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

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Characterization and Strain Improvement of a Hypercellulytic Variant, Trichoderma reesei SN1, by Genetic Engineering for Optimized Cellulase Production in Biomass Conversion Improvement Qian, Yuanchao; Zhong, Lixia; Hou, Yunhua Frontiers in Microbiology, Vol. 7 https://doi.org/10.3389/fmicb.2016.01349	journal	August 2016
Fungal Bioconversion of Lignocellulosic Residues; Opportunities & Perspectives Dashtban, Mehdi; Schraft, Heidi; Qin, Wensheng International Journal of Biological Sciences, Vol. 5, Issue 6, p. 578-595 https://doi.org/10.7150/ijbs.5.578	journal	January 2009

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