Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

Ikonomovic, Milos D.; Klunk, William E.; Abrahamson, Eric E.; Mathis, Chester A.; Price, Julie C.; Tsopelas, Nicholas D.; Lopresti, Brian J.; Ziolko, Scott; Bi, Wenzhu; Paljug, William R.; Debnath, Manik L.; Hope, Caroline E.; Isanski, Barbara A.; Hamilton, Ronald L.; DeKosky, Steven T.

doi:10.1093/brain/awn016

Title: Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

Journal Article · Wed Mar 12 00:00:00 EDT 2008 · Brain

DOI:https://doi.org/10.1093/brain/awn016· OSTI ID:1625298

Ikonomovic, Milos D. ^[1]; Klunk, William E. ^[2]; Abrahamson, Eric E. ^[3]; Mathis, Chester A. ^[4]; Price, Julie C. ^[4]; Tsopelas, Nicholas D. ^[5]; Lopresti, Brian J. ^[4]; Ziolko, Scott ^[4]; Bi, Wenzhu ^[4]; Paljug, William R. ^[3]; Debnath, Manik L. ^[5]; Hope, Caroline E. ^[3]; Isanski, Barbara A. ^[3]; Hamilton, Ronald L. ^[6]; DeKosky, Steven T. ^[7]

Univ. of Pittsburgh, PA (United States). School of Medicine. Depts. of Neurology and Psychiatry
Univ. of Pittsburgh, PA (United States). School of Medicine, Dept. of Psychiatry
Univ. of Pittsburgh, PA (United States). School of Medicine, Dept. of Neurology
Univ. of Pittsburgh, PA (United States). School of Medicine, Dept. of Radiology
Univ. of Pittsburgh, PA (United States). School of Medicine, Dept. of Psychiatry
Univ. of Pittsburgh, PA (United States). School of Medicine, Dept. of Neuropathology
Univ. of Pittsburgh, PA (United States). School of Medicine, Depts. of Neurology and Psychiatry

The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PiB) binds with high affinity to β-pleated sheet aggregates of the amyloid-β (Aβ) peptide in vitro. The in vivo retention of PiB in brains of people with Alzheimer's disease shows a regional distribution that is very similar to distribution of Aβ deposits observed post-mortem. However, the basis for regional variations in PiB binding in vivo, and the extent to which it binds to different types of Aβ-containing plaques and tau-containing neurofibrillary tangles (NFT), has not been thoroughly investigated. The present study examined 28 clinically diagnosed and autopsy-confirmed Alzheimer's disease subjects, including one Alzheimer's disease subject who had undergone PiB-PET imaging 10 months prior to death, to evaluate region- and substrate-specific binding of the highly fluorescent PiB derivative 6-CN-PiB. These data were then correlated with region-matched Aβ plaque load and peptide levels, [³H]PiB binding in vitro, and in vivo PET retention levels. We found that in Alzheimer's disease brain tissue sections, the preponderance of 6-CN-PiB binding is in plaques immunoreactive to either Aβ42 or Aβ40, and to vascular Aβ deposits. 6-CN-PiB labelling was most robust in compact/cored plaques in the prefrontal and temporal cortices. While diffuse plaques, including those in caudate nucleus and presubiculum, were less prominently labelled, amorphous Aβ plaques in the cerebellum were not detectable with 6-CN-PiB. Only a small subset of NFT were 6-CN-PiB positive; these resembled extracellular ‘ghost’ NFT. In Alzheimer's disease brain tissue homogenates, there was a direct correlation between [³H]PiB binding and insoluble Aβ peptide levels. In the Alzheimer's disease subject who underwent PiB-PET prior to death, in vivo PiB retention levels correlated directly with region-matched post-mortem measures of [³H]PiB binding, insoluble Aβ peptide levels, 6-CN-PiB- and Aβ plaque load, but not with measures of NFT. These results demonstrate, in a typical Alzheimer's disease brain, that PiB binding is highly selective for insoluble (fibrillar) Aβ deposits, and not for neurofibrillary pathology. The strong direct correlation of in vivo PiB retention with region-matched quantitative analyses of Aβ plaques in the same subject supports the validity of PiB-PET imaging as a method for in vivo evaluation of Aβ plaque burden.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Univ. of Pittsburgh, PA (United States)

Sponsoring Organization:: USDOE Office of Science (SC); National Institutes of Health (NIH); Alzheimer’s Association; Dana Foundation

Grant/Contract Number:: FG02-03ER63590; AG05133; AG025516

OSTI ID:: 1625298

Journal Information:: Brain, Vol. 131, Issue 6; ISSN 0006-8950

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United States

Language:: English

References (62)

Neuropathological stageing of Alzheimer-related changes Braak, H.; Braak, E. Acta Neuropathologica, Vol. 82, Issue 4 https://doi.org/10.1007/BF00308809	journal	September 1991
Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data Logan, Jean; Fowler, Joanna S.; Volkow, Nora D. Journal of Cerebral Blood Flow & Metabolism, Vol. 16, Issue 5 https://doi.org/10.1097/00004647-199609000-00008	journal	September 1996
Diagnosis of Alzheimer's disease Byrne, E. J. BMJ, Vol. 302, Issue 6767 https://doi.org/10.1136/bmj.302.6767.48	journal	January 1991
Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline Näslund, Jan JAMA, Vol. 283, Issue 12 https://doi.org/10.1001/jama.283.12.1571	journal	March 2000
Imaging β-Amyloid Plaques and Neurofibrillary Tangles in the Aging Human Brain Mathis, C.; Wang, Y.; Klunk, W. Current Pharmaceutical Design, Vol. 10, Issue 13 https://doi.org/10.2174/1381612043384772	journal	May 2004
Association of Increased Cortical Soluble Aβ42 Levels With Diffuse Plaques After Severe Brain Injury in Humans DeKosky, Steven T.; Abrahamson, Eric E.; Ciallella, John R. Archives of Neurology, Vol. 64, Issue 4 https://doi.org/10.1001/archneur.64.4.541	journal	April 2007
Erratum: Biomarkers of Alzheimer Disease CONTINUUM: Lifelong Learning in Neurology, Vol. 19, Issue 4, p. 892 https://doi.org/10.1212/01.con.0000433295.45962.20	journal	August 2013
Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles. Tabaton, M.; Cammarata, S.; Mancardi, G. Proceedings of the National Academy of Sciences, Vol. 88, Issue 6 https://doi.org/10.1073/pnas.88.6.2098	journal	March 1991
The “Nonamyloidogenic” p3 Fragment (Amyloid β17-42) Is a Major Constituent of Down's Syndrome Cerebellar Preamyloid Lalowski, Maciej; Golabek, Adam; Lemere, Cynthia A. Journal of Biological Chemistry, Vol. 271, Issue 52 https://doi.org/10.1074/jbc.271.52.33623	journal	December 1996
The Role of Biomarkers in Clinical Trials for Alzheimer Disease Thal, Leon J.; Kantarci, Kejal; Reiman, Eric M. Alzheimer Disease & Associated Disorders, Vol. 20, Issue 1 https://doi.org/10.1097/01.wad.0000191420.61260.a8	journal	January 2006
Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP Kamal, Adeela; Almenar-Queralt, Angels; LeBlanc, James F. Nature, Vol. 414, Issue 6864 https://doi.org/10.1038/414643a	journal	December 2001
Pyroglutamate-modified amyloid β-peptides - AβN3(pE) - strongly affect cultured neuron and astrocyte survival: N-modified amyloid-β severely affect neurones Russo, Claudio; Violani, Elisabetta; Salis, Serena Journal of Neurochemistry, Vol. 82, Issue 6 https://doi.org/10.1046/j.1471-4159.2002.01107.x	journal	September 2002
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS--ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease McKhann, G.; Drachman, D.; Folstein, M. Neurology, Vol. 77, Issue 4 https://doi.org/10.1212/01.wnl.0000400650.92875.cf	journal	July 2011
Amyloid β Protein Starting Pyroglutamate at Position 3 Is a Major Component of the Amyloid Deposits in the Alzheimer's Disease Brain Harigaya, Yasuo; Saido, Takaomi C.; Eckman, Christopher B. Biochemical and Biophysical Research Communications, Vol. 276, Issue 2 https://doi.org/10.1006/bbrc.2000.3490	journal	September 2000
Missorting of Tau in Neurons Causes Degeneration of Synapses That Can Be Rescued by the Kinase MARK2/Par-1 Thies, E.; Mandelkow, E. -M. Journal of Neuroscience, Vol. 27, Issue 11 https://doi.org/10.1523/JNEUROSCI.4674-06.2007	journal	March 2007
Monitoring pathological assembly of tau and ?-amyloid proteins in Alzheimer's disease Mena, Ra�l; Edwards, Patricia; P�rez-Olvera, Ofelia Acta Neuropathologica, Vol. 89, Issue 1 https://doi.org/10.1007/BF00294259	journal	January 1995
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease McKhann, G.; Drachman, D.; Folstein, M. Neurology, Vol. 34, Issue 7 https://doi.org/10.1212/WNL.34.7.939	journal	July 1984
PET of Brain Amyloid and Tau in Mild Cognitive Impairment Small, Gary W.; Kepe, Vladimir; Ercoli, Linda M. New England Journal of Medicine, Vol. 355, Issue 25 https://doi.org/10.1056/NEJMoa054625	journal	December 2006
Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography Maeda, J.; Ji, B.; Irie, T. Journal of Neuroscience, Vol. 27, Issue 41 https://doi.org/10.1523/JNEUROSCI.0673-07.2007	journal	October 2007
Diagnosis of Alzheimer's disease. Wald, N.; Parkes, C.; Smith, A. D. BMJ, Vol. 302, Issue 6771 https://doi.org/10.1136/bmj.302.6771.292-b	journal	February 1991
Diagnosis of Alzheimerʼs Disease in a Community Hospital-Based Brain Bank Program Pearl, Gary S. Southern Medical Journal, Vol. 90, Issue 7 https://doi.org/10.1097/00007611-199707000-00013	journal	January 1997
Aβ Species Removal After Aβ ₄₂ Immunization Nicoll, James A. R.; Barton, Edward; Boche, Delphine Journal of Neuropathology & Experimental Neurology, Vol. 65, Issue 11 https://doi.org/10.1097/01.jnen.0000240466.10758.ce	journal	November 2006
Research evaluation and diagnosis of probable Alzheimer's disease over the last two decades: I Lopez, O. L.; Becker, J. T.; Klunk, W. Neurology, Vol. 55, Issue 12 https://doi.org/10.1212/WNL.55.12.1854	journal	December 2000
Role of biomarkers in studies of presymptomatic Alzheimer's disease Morris, John C.; Kimberly, A.; Quaid, K. Alzheimer's & Dementia, Vol. 1, Issue 2 https://doi.org/10.1016/j.jalz.2005.09.013	journal	October 2005
Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43) Iwatsubo, Takeshi; Odaka, Asano; Suzuki, Nobuhiro Neuron, Vol. 13, Issue 1 https://doi.org/10.1016/0896-6273(94)90458-8	journal	July 1994
Alzheimer patients and Down patients: Cerebral preamyloid deposits differ ultrastructurally and histochemically from the amyloid of senile plaques Verga, Laura; Frangione, Blas; Tagliavini, Fabrizio Neuroscience Letters, Vol. 105, Issue 3 https://doi.org/10.1016/0304-3940(89)90636-8	journal	November 1989
Mild cognitive impairment Gauthier, Serge; Reisberg, Barry; Zaudig, Michael The Lancet, Vol. 367, Issue 9518 https://doi.org/10.1016/S0140-6736(06)68542-5	journal	April 2006
Synthesis and Evaluation of ¹¹ C-Labeled 6-Substituted 2-Arylbenzothiazoles as Amyloid Imaging Agents Mathis, Chester A.; Wang, Yanming; Holt, Daniel P. Journal of Medicinal Chemistry, Vol. 46, Issue 13 https://doi.org/10.1021/jm030026b	journal	June 2003
Diagnosis of Alzheimer's Disease Khachaturian, Z. S. Archives of Neurology, Vol. 42, Issue 11 https://doi.org/10.1001/archneur.1985.04060100083029	journal	November 1985
Utility of the Apolipoprotein E Genotype in the Diagnosis of Alzheimer's Disease New England Journal of Medicine, Vol. 338, Issue 18, p. 1325-1325 https://doi.org/10.1056/nejm199804303381823	journal	April 1998
PIB is a non-specific imaging marker of amyloid-beta (A ) peptide-related cerebral amyloidosis Lockhart, A.; Lamb, J. R.; Osredkar, T. Brain, Vol. 130, Issue 10 https://doi.org/10.1093/brain/awm191	journal	October 2007
Research evaluation and diagnosis of possible Alzheimer's disease over the last two decades: II Lopez, O. L.; Becker, J. T.; Klunk, W. Neurology, Vol. 55, Issue 12 https://doi.org/10.1212/WNL.55.12.1863	journal	December 2000
The Binding of 2-(4′-Methylaminophenyl)Benzothiazole to Postmortem Brain Homogenates Is Dominated by the Amyloid Component Klunk, William E.; Wang, Yanming; Huang, Guo-feng The Journal of Neuroscience, Vol. 23, Issue 6 https://doi.org/10.1523/JNEUROSCI.23-06-02086.2003	journal	March 2003
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease Engler, H.; Forsberg, A.; Almkvist, O. Brain, Vol. 129, Issue 11 https://doi.org/10.1093/brain/awl178	journal	September 2006
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B: Imaging Amyloid in AD with PIB Klunk, William E.; Engler, Henry; Nordberg, Agneta Annals of Neurology, Vol. 55, Issue 3 https://doi.org/10.1002/ana.20009	journal	January 2004
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease Mirra, S. S.; Heyman, A.; McKeel, D. Neurology, Vol. 41, Issue 4 https://doi.org/10.1212/WNL.41.4.479	journal	April 1991
Imaging -amyloid burden in aging and dementia Rowe, C. C.; Ng, S.; Ackermann, U. Neurology, Vol. 68, Issue 20 https://doi.org/10.1212/01.wnl.0000261919.22630.ea	journal	May 2007
Molecular Imaging With Pittsburgh Compound B Confirmed at Autopsy: A Case Report Bacskai, Brian J.; Frosch, Matthew P.; Freeman, Stefanie H. Archives of Neurology, Vol. 64, Issue 3 https://doi.org/10.1001/archneur.64.3.431	journal	March 2007
Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease. Spillantini, M. G.; Goedert, M.; Jakes, R. Proceedings of the National Academy of Sciences, Vol. 87, Issue 10 https://doi.org/10.1073/pnas.87.10.3952	journal	May 1990
Simplified Reference Tissue Model for PET Receptor Studies Lammertsma, Adriaan A.; Hume, Susan P. NeuroImage, Vol. 4, Issue 3 https://doi.org/10.1006/nimg.1996.0066	journal	December 1996
Imaging of amyloid burden and distribution in cerebral amyloid angiopathy Johnson, Keith A.; Gregas, Matt; Becker, John A. Annals of Neurology, Vol. 62, Issue 3 https://doi.org/10.1002/ana.21164	journal	September 2007
Biological Markers of Alzheimer’s Disease Klunk, W. E. Neurobiology of Aging, Vol. 19, Issue 2 https://doi.org/10.1016/S0197-4580(98)00013-X	journal	March 1998
Utility of the Apolipoprotein E Genotype in the Diagnosis of Alzheimer's Disease Mayeux, Richard; Saunders, Ann M.; Shea, Steven New England Journal of Medicine, Vol. 338, Issue 8 https://doi.org/10.1056/NEJM199802193380804	journal	February 1998
Staging the pathological assembly of truncated tau protein into paired helical filaments in Alzheimer's disease Mena, R.; Edwards, Patricia C.; Harrington, Charles R. Acta Neuropathologica, Vol. 91, Issue 6 https://doi.org/10.1007/s004010050477	journal	May 1996
Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain Klunk, William E.; Wang, Yanming; Huang, Guo-feng Life Sciences, Vol. 69, Issue 13 https://doi.org/10.1016/S0024-3205(01)01232-2	journal	August 2001
Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes Mercken, Marc; Vandermeeren, Marc; Lübke, Ursula Acta Neuropathologica, Vol. 84, Issue 3 https://doi.org/10.1007/BF00227819	journal	August 1992
X‐34 Labeling of Abnormal Protein Aggregates During the Progression of Alzheimer's Disease Ikonomovic, Milos D.; Abrahamson, Eric E.; Isanski, Barbara A. Methods in Enzymology https://doi.org/10.1016/S0076-6879(06)12009-1	book	January 2006
A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain Mathis, Chester A.; Bacskai, Brian J.; Kajdasz, Stephen T. Bioorganic & Medicinal Chemistry Letters, Vol. 12, Issue 3 https://doi.org/10.1016/S0960-894X(01)00734-X	journal	February 2002
Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B Price, Julie C.; Klunk, William E.; Lopresti, Brian J. Journal of Cerebral Blood Flow & Metabolism, Vol. 25, Issue 11 https://doi.org/10.1038/sj.jcbfm.9600146	journal	May 2005
Binding of the Positron Emission Tomography Tracer Pittsburgh Compound-B Reflects the Amount of Amyloid- in Alzheimer's Disease Brain But Not in Transgenic Mouse Brain Klunk, W. E. Journal of Neuroscience, Vol. 25, Issue 46 https://doi.org/10.1523/JNEUROSCI.2990-05.2005	journal	November 2005
Kunitz Protease Inhibitor-Containing Amyloid β Protein Precursor Immunoreactivity in Alzheimer's Disease Hyman, B. T.; Tanzi, R. E.; Marzloff, K. Journal of Neuropathology & Experimental Neurology, Vol. 51, Issue 1 https://doi.org/10.1097/00005072-199201000-00009	journal	January 1992
A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography Mintun, Mark A.; Raichle, Marcus E.; Kilbourn, Michael R. Annals of Neurology, Vol. 15, Issue 3 https://doi.org/10.1002/ana.410150302	journal	March 1984
Imaging Technology for Neurodegenerative Diseases: Progress Toward Detection of Specific Pathologies Mathis, Chester A.; Klunk, William E.; Price, Julie C. Archives of Neurology, Vol. 62, Issue 2 https://doi.org/10.1001/archneur.62.2.196	journal	February 2005
Biomarkers of Alzheimer Disease Growdon, John H. Archives of Neurology, Vol. 56, Issue 3 https://doi.org/10.1001/archneur.56.3.281	journal	March 1999
PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment Kemppainen, N. M.; Aalto, S.; Wilson, I. A. Neurology, Vol. 68, Issue 19 https://doi.org/10.1212/01.wnl.0000260969.94695.56	journal	May 2007
Biological markers of Alzheimer's disease Bruyn, G. W. Journal of the Neurological Sciences, Vol. 96, Issue 1 https://doi.org/10.1016/0022-510x(90)90067-w	journal	April 1990
A4 amyloid protein immunoreactivity is present in Alzheimer's disease neurofibrillary tangles Hyman, B. T.; Van Hoesen, G. W.; Beyreuther, K. Neuroscience Letters, Vol. 101, Issue 3 https://doi.org/10.1016/0304-3940(89)90559-4	journal	July 1989
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. Masters, C. L.; Multhaup, G.; Simms, G. The EMBO Journal, Vol. 4, Issue 11 https://doi.org/10.1002/j.1460-2075.1985.tb04000.x	journal	November 1985
Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease. Grundke-Iqbal, I.; Iqbal, K.; George, L. Proceedings of the National Academy of Sciences, Vol. 86, Issue 8 https://doi.org/10.1073/pnas.86.8.2853	journal	April 1989
An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease Guntern, R.; Bouras, C.; Hof, P. R. Experientia, Vol. 48, Issue 1 https://doi.org/10.1007/bf01923594	journal	January 1992
Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography Klunk, William E.; Engler, Henry; Nordberg, Agneta Neuroimaging Clinics of North America, Vol. 13, Issue 4 https://doi.org/10.1016/s1052-5149(03)00092-3	journal	November 2003
In Vitro Characterization of Pittsburgh Compound-B Binding to Lewy Bodies Fodero-Tavoletti, M. T.; Smith, D. P.; McLean, C. A. Journal of Neuroscience, Vol. 27, Issue 39 https://doi.org/10.1523/jneurosci.0630-07.2007	journal	September 2007

Cited By (181)

Synthesis and Evaluation of a Zr-89-Labeled Monoclonal Antibody for Immuno-PET Imaging of Amyloid-β Deposition in the Brain Fissers, Jens; Waldron, Ann-Marie; De Vijlder, Thomas Molecular Imaging and Biology, Vol. 18, Issue 4 https://doi.org/10.1007/s11307-016-0935-z	journal	February 2016
Pittsburgh compound B and the postmortem diagnosis of alzheimer disease Niedowicz, Dana M.; Beckett, Tina L.; Matveev, Sergey Annals of Neurology, Vol. 72, Issue 4 https://doi.org/10.1002/ana.23633	journal	October 2012
Stereotactic brain injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer's disease dementia: A phase 1 clinical trial Kim, Hee Jin; Seo, Sang Won; Chang, Jong Wook Alzheimer's & Dementia: Translational Research & Clinical Interventions, Vol. 1, Issue 2 https://doi.org/10.1016/j.trci.2015.06.007	journal	July 2015
Cerebral Amyloid Angiopathy, Alzheimer’s Disease and MicroRNA: miRNA as Diagnostic Biomarkers and Potential Therapeutic Targets Weldon Furr, J.; Morales-Scheihing, Diego; Manwani, Bharti NeuroMolecular Medicine, Vol. 21, Issue 4 https://doi.org/10.1007/s12017-019-08568-0	journal	October 2019
Quantitative imaging of protein targets in the human brain with PET Gunn, Roger N.; Slifstein, Mark; Searle, Graham E. Physics in Medicine and Biology, Vol. 60, Issue 22 https://doi.org/10.1088/0031-9155/60/22/r363	journal	October 2015
Reference tissue normalization in longitudinal 18F-florbetapir positron emission tomography of late mild cognitive impairment Shokouhi, Sepideh; Mckay, John W.; Baker, Suzanne L. Alzheimer's Research & Therapy, Vol. 8, Issue 1 https://doi.org/10.1186/s13195-016-0172-3	journal	January 2016
Appropriate use criteria for lumbar puncture and cerebrospinal fluid testing in the diagnosis of Alzheimer's disease Shaw, Leslie M.; Arias, Jalayne; Blennow, Kaj Alzheimer's & Dementia, Vol. 14, Issue 11 https://doi.org/10.1016/j.jalz.2018.07.220	journal	October 2018
Cerebral amyloid PET imaging in Alzheimer’s disease Jack, Clifford R.; Barrio, Jorge R.; Kepe, Vladimir Acta Neuropathologica, Vol. 126, Issue 5 https://doi.org/10.1007/s00401-013-1185-7	journal	October 2013
Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B Handen, Benjamin L.; Cohen, Ann D.; Channamalappa, Umapathy Alzheimer's & Dementia, Vol. 8, Issue 6 https://doi.org/10.1016/j.jalz.2011.09.229	journal	November 2012
2018 Alzheimer's disease facts and figures Association, Alzheimer's Alzheimer's & Dementia, Vol. 14, Issue 3, p. 367-429 https://doi.org/10.1016/j.jalz.2018.02.001	journal	January 2018
Human apoE Isoforms Differentially Regulate Brain Amyloid- Peptide Clearance Castellano, J. M.; Kim, J.; Stewart, F. R. Science Translational Medicine, Vol. 3, Issue 89 https://doi.org/10.1126/scitranslmed.3002156	journal	June 2011
Comparison of ¹⁸ F-florbetaben quantification results using the standard Centiloid, MR-based, and MR-less CapAIBL ^® approaches: Validation against histopathology Doré, Vincent; Bullich, Santiago; Rowe, Christopher C. Alzheimer's & Dementia, Vol. 15, Issue 6 https://doi.org/10.1016/j.jalz.2019.02.005	journal	May 2019
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study Ramanan, V. K.; Risacher, S. L.; Nho, K. Molecular Psychiatry, Vol. 19, Issue 3 https://doi.org/10.1038/mp.2013.19	journal	February 2013
Invited Review: The spectrum of age‐related small vessel diseases: potential overlap and interactions of amyloid and nonamyloid vasculopathies Schreiber, S.; Wilisch‐Neumann, A.; Schreiber, F. Neuropathology and Applied Neurobiology, Vol. 46, Issue 3 https://doi.org/10.1111/nan.12576	journal	September 2019
Aβ amyloid and glucose metabolism in three variants of primary progressive aphasia Rabinovici, Gil D.; Jagust, William J.; Furst, Ansgar J. Annals of Neurology, Vol. 64, Issue 4 https://doi.org/10.1002/ana.21451	journal	October 2008
18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease Fodero-Tavoletti, M. T.; Okamura, N.; Furumoto, S. Brain, Vol. 134, Issue 4 https://doi.org/10.1093/brain/awr038	journal	March 2011
Imaging Alzheimer's disease pathophysiology with PET Schilling, Lucas Porcello; Zimmer, Eduardo R.; Shin, Monica Dementia & Neuropsychologia, Vol. 10, Issue 2 https://doi.org/10.1590/s1980-5764-2016dn1002003	journal	June 2016
Fibrillar amyloid- burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease Reiman, E. M.; Chen, K.; Liu, X. Proceedings of the National Academy of Sciences, Vol. 106, Issue 16 https://doi.org/10.1073/pnas.0900345106	journal	April 2009
Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation Villeneuve, Sylvia; Rabinovici, Gil D.; Cohn-Sheehy, Brendan I. Brain, Vol. 138, Issue 7 https://doi.org/10.1093/brain/awv112	journal	May 2015
Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease Zhang, Xueli; Tian, Yanli; Zhang, Can Proceedings of the National Academy of Sciences, Vol. 112, Issue 31 https://doi.org/10.1073/pnas.1505420112	journal	July 2015
Characterization of AZD4694, a novel fluorinated Aβ plaque neuroimaging PET radioligand: AZD4694 a new amyloid PET radioligand Juréus, Anders; Swahn, Britt-Marie; Sandell, Johan Journal of Neurochemistry, Vol. 114, Issue 3 https://doi.org/10.1111/j.1471-4159.2010.06812.x	journal	June 2010
Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology Perez-Nievas, Beatriz G.; Stein, Thor D.; Tai, Hwan-Ching Brain, Vol. 136, Issue 8 https://doi.org/10.1093/brain/awt171	journal	July 2013
The combination of apolipoprotein E4, age and Alzheimer's Disease Assessment Scale – Cognitive Subscale improves the prediction of amyloid positron emission tomography status in clinically diagnosed mild cognitive impairment Ba, M.; Ng, K. P.; Gao, X. European Journal of Neurology, Vol. 26, Issue 5 https://doi.org/10.1111/ene.13881	journal	January 2019
Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program: Arizona Brain and Body Donation Program Beach, Thomas G.; Adler, Charles H.; Sue, Lucia I. Neuropathology, Vol. 35, Issue 4 https://doi.org/10.1111/neup.12189	journal	January 2015
Cortical florbetapir-PET amyloid load in prodromal Alzheimer’s disease patients Saint-Aubert, Laure; Barbeau, Emmanuel J.; Péran, Patrice EJNMMI Research, Vol. 3, Issue 1 https://doi.org/10.1186/2191-219x-3-43	journal	January 2013
β-Amyloid is Associated with Aberrant Metabolic Connectivity in Subjects with Mild Cognitive Impairment Carbonell, Felix; Charil, Arnaud; Zijdenbos, Alex P. Journal of Cerebral Blood Flow & Metabolism, Vol. 34, Issue 7 https://doi.org/10.1038/jcbfm.2014.66	journal	April 2014
Is Olfactory Epithelium Biopsy Useful for Confirming Alzheimer’s Disease? Godoy, Maria Dantas Costa Lima; Fornazieri, Marco Aurélio; Doty, Richard L. Annals of Otology, Rhinology & Laryngology, Vol. 128, Issue 3 https://doi.org/10.1177/0003489418814865	journal	December 2018
AZD2184: a radioligand for sensitive detection of β-amyloid deposits Johnson, Allan E.; Jeppsson, Fredrik; Sandell, Johan Journal of Neurochemistry, Vol. 108, Issue 5 https://doi.org/10.1111/j.1471-4159.2008.05861.x	journal	March 2009
Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer’s disease Villemagne, Victor L.; Klunk, William E.; Mathis, Chester A. European Journal of Nuclear Medicine and Molecular Imaging, Vol. 39, Issue 2 https://doi.org/10.1007/s00259-011-2045-0	journal	January 2012
Correspondence between in vivo 11C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques Driscoll, Ira; Troncoso, Juan C.; Rudow, Gay Acta Neuropathologica, Vol. 124, Issue 6 https://doi.org/10.1007/s00401-012-1025-1	journal	August 2012
Hypertension and obesity moderate the relationship between β-amyloid and cognitive decline in midlife Clark, Lindsay R.; Koscik, Rebecca L.; Allison, Samantha L. Alzheimer's & Dementia, Vol. 15, Issue 3 https://doi.org/10.1016/j.jalz.2018.09.008	journal	October 2018
Transcranial magnetic stimulation and amyloid markers in mild cognitive impairment: impact on diagnostic confidence and diagnostic accuracy Padovani, Alessandro; Benussi, Alberto; Cotelli, Maria Sofia Alzheimer's Research & Therapy, Vol. 11, Issue 1 https://doi.org/10.1186/s13195-019-0555-3	journal	December 2019
Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammation in Neurodegenerative Diseases Madeira, Maria H.; Boia, Raquel; Ambrósio, António F. Mediators of Inflammation, Vol. 2017 https://doi.org/10.1155/2017/4761081	journal	January 2017
Multisite study of the relationships between antemortem [ ¹¹ C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology La Joie, Renaud; Ayakta, Nagehan; Seeley, William W. Alzheimer's & Dementia, Vol. 15, Issue 2 https://doi.org/10.1016/j.jalz.2018.09.001	journal	October 2018
Functional Alterations in Memory Networks in Early Alzheimer’s Disease Sperling, Reisa A.; Dickerson, Bradford C.; Pihlajamaki, Maija NeuroMolecular Medicine, Vol. 12, Issue 1 https://doi.org/10.1007/s12017-009-8109-7	journal	January 2010
Community perceptions related to brain donation: Evidence for intervention Striley, Catherine W.; Milani, Sadaf A.; Kwiatkowski, Evan Alzheimer's & Dementia, Vol. 15, Issue 2 https://doi.org/10.1016/j.jalz.2018.09.005	journal	October 2018
The influence of biological and technical factors on quantitative analysis of amyloid PET: Points to consider and recommendations for controlling variability in longitudinal data Schmidt, Mark E.; Chiao, Ping; Klein, Gregory Alzheimer's & Dementia, Vol. 11, Issue 9 https://doi.org/10.1016/j.jalz.2014.09.004	journal	November 2014
Pittsburgh Compound B (11C-PIB) and Fluorodeoxyglucose (18 F-FDG) PET in Patients With Alzheimer Disease, Mild Cognitive Impairment, and Healthy Controls Devanand, D. P.; Mikhno, Arthur; Pelton, Gregory H. Journal of Geriatric Psychiatry and Neurology, Vol. 23, Issue 3 https://doi.org/10.1177/0891988710363715	journal	April 2010
Identifying Early Markers of Alzheimer's Disease using Quantitative Multiplex Proteomic Immunoassay Panels Soares, Holly D.; Chen, Yu; Sabbagh, Marwin Annals of the New York Academy of Sciences, Vol. 1180, Issue 1 https://doi.org/10.1111/j.1749-6632.2009.05066.x	journal	October 2009
The impact of transcranial magnetic stimulation on diagnostic confidence in patients with Alzheimer disease Benussi, Alberto; Alberici, Antonella; Ferrari, Clarissa Alzheimer's Research & Therapy, Vol. 10, Issue 1 https://doi.org/10.1186/s13195-018-0423-6	journal	September 2018
Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study Leuzy, Antoine; Chiotis, Konstantinos; Hasselbalch, Steen G. Brain, Vol. 139, Issue 9 https://doi.org/10.1093/brain/aww160	journal	July 2016
The behavioural/dysexecutive variant of Alzheimer’s disease: clinical, neuroimaging and pathological features Ossenkoppele, Rik; Pijnenburg, Yolande A. L.; Perry, David C. Brain, Vol. 138, Issue 9 https://doi.org/10.1093/brain/awv191	journal	July 2015
Mitochondrial ATP synthase activity is impaired by suppressed O -GlcNAcylation in Alzheimer's disease Cha, Moon-Yong; Cho, Hyun Jin; Kim, Chaeyoung Human Molecular Genetics, Vol. 24, Issue 22 https://doi.org/10.1093/hmg/ddv358	journal	September 2015
Should we disclose amyloid imaging results to cognitively normal individuals? Grill, Joshua D.; Johnson, David K.; Burns, Jeffrey M. Neurodegenerative Disease Management, Vol. 3, Issue 1 https://doi.org/10.2217/nmt.12.75	journal	February 2013
Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging Johnson, Keith A.; Sperling, Reisa A.; Gidicsin, Christopher M. Alzheimer's & Dementia, Vol. 9, Issue 5S https://doi.org/10.1016/j.jalz.2012.10.007	journal	February 2013
Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection Ikonomovic, Milos D.; Buckley, Chris J.; Heurling, Kerstin Acta Neuropathologica Communications, Vol. 4, Issue 1 https://doi.org/10.1186/s40478-016-0399-z	journal	December 2016
Suboptimal validity of amyloid imaging-based diagnosis and management of Alzheimer’s disease: why it is time to abandon the approach Alavi, Abass; Barrio, Jorge R.; Werner, Thomas J. European Journal of Nuclear Medicine and Molecular Imaging, Vol. 47, Issue 2 https://doi.org/10.1007/s00259-019-04564-5	journal	October 2019
Alzheimer’s Prevention Initiative: a proposal to evaluate presymptomatic treatments as quickly as possible Reiman, Eric M.; Langbaum, Jessica BS; Tariot, Pierre N. Biomarkers in Medicine, Vol. 4, Issue 1 https://doi.org/10.2217/bmm.09.91	journal	February 2010
Performance of [ ¹⁸ F]flutemetamol amyloid imaging against the neuritic plaque component of CERAD and the current (2012) NIA‐AA recommendations for the neuropathologic diagnosis of Alzheimer's disease Salloway, Stephen; Gamez, Jose E.; Singh, Upinder Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol. 9, Issue 1 https://doi.org/10.1016/j.dadm.2017.06.001	journal	January 2017
Quantitative Analysis of Brain ¹⁸F-fluordesoxyglucose and Early-Phase ¹⁸F-florbetapir Positron Emission Tomography Seiffert, Alexander P.; Gómez-Grande, Adolfo; Sánchez-González, Patricia IFMBE Proceedings https://doi.org/10.1007/978-3-030-31635-8_52	book	September 2019
Neuropathological correlates of amyloid PET imaging in Down syndrome Abrahamson, Eric E.; Head, Elizabeth; Lott, Ira T. Developmental Neurobiology, Vol. 79, Issue 7 https://doi.org/10.1002/dneu.22713	journal	July 2019
APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging Morris, John C.; Roe, Catherine M.; Xiong, Chengjie Annals of Neurology, Vol. 67, Issue 1 https://doi.org/10.1002/ana.21843	journal	January 2010
Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: Phase 3 study Sabri, Osama; Sabbagh, Marwan N.; Seibyl, John Alzheimer's & Dementia, Vol. 11, Issue 8 https://doi.org/10.1016/j.jalz.2015.02.004	journal	March 2015
Independent information from cerebrospinal fluid amyloid-β and florbetapir imaging in Alzheimer's disease Mattsson, Niklas; Insel, Philip S.; Donohue, Michael Brain, Vol. 138, Issue 3 https://doi.org/10.1093/brain/awu367	journal	December 2014
Highly efficient solid phase supported radiosynthesis of [ ¹¹ C]PiB using tC18 cartridge as a “3-in-1” production entity Boudjemeline, Mehdi; Hopewell, Robert; Rochon, Pierre-Luc Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 60, Issue 14 https://doi.org/10.1002/jlcr.3569	journal	November 2017
Clinicopathologic and ¹¹ C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer’s disease spectrum Murray, Melissa E.; Lowe, Val J.; Graff-Radford, Neill R. Brain, Vol. 138, Issue 5 https://doi.org/10.1093/brain/awv050	journal	March 2015
Diagnose ohne Therapie: Frühdiagnostik der Alzheimer-Krankheit im Stadium der leichten kognitiven Beeinträchtigung Gertz, H. -J.; Kurz, A. Der Nervenarzt, Vol. 82, Issue 9 https://doi.org/10.1007/s00115-010-3213-3	journal	January 2011
The challenges of tau imaging Villemagne, Victor L.; Furumoto, Shozo; Fodero-Tavoletti, Michelle Future Neurology, Vol. 7, Issue 4 https://doi.org/10.2217/fnl.12.34	journal	July 2012
Using PET with 18F-AV-45 (florbetapir) to quantify brain amyloid load in a clinical environment Camus, V.; Payoux, P.; Barré, L. European Journal of Nuclear Medicine and Molecular Imaging, Vol. 39, Issue 4 https://doi.org/10.1007/s00259-011-2021-8	journal	January 2012
Imaging Brain Effects of APOE4 in Cognitively Normal Individuals Across the Lifespan Fouquet, Marine; Besson, Florent L.; Gonneaud, Julie Neuropsychology Review, Vol. 24, Issue 3 https://doi.org/10.1007/s11065-014-9263-8	journal	August 2014
Diagnostic accuracy of 18F amyloid PET tracers for the diagnosis of Alzheimer’s disease: a systematic review and meta-analysis Morris, Elizabeth; Chalkidou, Anastasia; Hammers, Alexander European Journal of Nuclear Medicine and Molecular Imaging, Vol. 43, Issue 2 https://doi.org/10.1007/s00259-015-3228-x	journal	November 2015
Brain amyloid and cognition in Lewy body diseases Gomperts, Stephen N.; Locascio, Joseph J.; Marquie, Marta Movement Disorders, Vol. 27, Issue 8 https://doi.org/10.1002/mds.25048	journal	June 2012
Salivary Biomarkers for Alzheimer’s Disease and Related Disorders Ashton, Nicholas J.; Ide, Mark; Zetterberg, Henrik Neurology and Therapy, Vol. 8, Issue S2 https://doi.org/10.1007/s40120-019-00168-1	journal	December 2019
Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease Jack, C. R.; Wiste, H. J.; Vemuri, P. Brain, Vol. 133, Issue 11 https://doi.org/10.1093/brain/awq277	journal	October 2010
In vivo characterization of the early states of the amyloid-beta network Sepulcre, Jorge; Sabuncu, Mert R.; Becker, Alex Brain, Vol. 136, Issue 7 https://doi.org/10.1093/brain/awt146	journal	June 2013
The relationship between cerebrospinal fluid markers of Alzheimer pathology and positron emission tomography tau imaging Gordon, Brian A.; Friedrichsen, Karl; Brier, Matthew Brain, Vol. 139, Issue 8 https://doi.org/10.1093/brain/aww139	journal	June 2016
CSF A β 42/A β 40 and A β 42/A β 38 ratios: better diagnostic markers of Alzheimer disease Janelidze, Shorena; Zetterberg, Henrik; Mattsson, Niklas Annals of Clinical and Translational Neurology, Vol. 3, Issue 3 https://doi.org/10.1002/acn3.274	journal	January 2016
Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue Ni, R.; Gillberg, P. -G.; Bergfors, A. Brain, Vol. 136, Issue 7 https://doi.org/10.1093/brain/awt142	journal	June 2013
PET imaging of brain amyloid in dementia: a review Quigley, Harriet; Colloby, Sean J.; O'Brien, John T. International Journal of Geriatric Psychiatry, Vol. 26, Issue 10 https://doi.org/10.1002/gps.2640	journal	December 2010
The clinical safety, biodistribution and internal radiation dosimetry of flutemetamol (18F) injection in healthy Japanese adult volunteers Senda, Michio; Brooks, David J.; Farrar, Gill Annals of Nuclear Medicine, Vol. 29, Issue 7 https://doi.org/10.1007/s12149-015-0986-2	journal	June 2015
Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease Jack, Clifford R.; Lowe, Val J.; Weigand, Stephen D. Brain, Vol. 132, Issue 5 https://doi.org/10.1093/brain/awp062	journal	March 2009
Amyloid imaging, risk disclosure and Alzheimer’s disease: ethical and practical issues Roberts, J. Scott; Dunn, Laura B.; Rabinovici, Gil D. Neurodegenerative Disease Management, Vol. 3, Issue 3 https://doi.org/10.2217/nmt.13.25	journal	June 2013
Parenchymal and vascular Aβ-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease Thal, Dietmar Rudolf; Griffin, W. Sue T.; Braak, Heiko Journal of Cellular and Molecular Medicine, Vol. 12, Issue 5b https://doi.org/10.1111/j.1582-4934.2008.00411.x	journal	July 2008
The search for a unique Raman signature of amyloid-beta plaques in human brain tissue from Alzheimer's disease patients Lochocki, Benjamin; Morrema, Tjado H. J.; Ariese, Freek The Analyst, Vol. 145, Issue 5 https://doi.org/10.1039/c9an02087j	journal	January 2020
Appropriate Use Criteria for Amyloid PET: A Report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer’s Association Johnson, Keith A.; Minoshima, Satoshi; Bohnen, Nicolaas I. Journal of Nuclear Medicine, Vol. 54, Issue 3 https://doi.org/10.2967/jnumed.113.120618	journal	January 2013
Microvasculature changes and cerebral amyloid angiopathy in Alzheimer’s disease and their potential impact on therapy Weller, Roy O.; Boche, Delphine; Nicoll, James A. R. Acta Neuropathologica, Vol. 118, Issue 1 https://doi.org/10.1007/s00401-009-0498-z	journal	February 2009
Amyloid and tau proteins in cortical brain biopsy and Alzheimer's disease Leinonen, Ville; Koivisto, Anne M.; Savolainen, Sakari Annals of Neurology, Vol. 68, Issue 4 https://doi.org/10.1002/ana.22100	journal	October 2010
The use of PET in Alzheimer disease Nordberg, Agneta; Rinne, Juha O.; Kadir, Ahmadul Nature Reviews Neurology, Vol. 6, Issue 2 https://doi.org/10.1038/nrneurol.2009.217	journal	February 2010
Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer’s disease pathology Harada, Ryuichi; Okamura, Nobuyuki; Furumoto, Shozo European Journal of Nuclear Medicine and Molecular Imaging, Vol. 40, Issue 1 https://doi.org/10.1007/s00259-012-2261-2	journal	October 2012
¹⁸ F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial: ¹⁸ F-Flutemetamol Phase 2 Trial Vandenberghe, Rik; Van Laere, Koen; Ivanoiu, Adrian Annals of Neurology, Vol. 68, Issue 3 https://doi.org/10.1002/ana.22068	journal	August 2010
Mild to moderate Alzheimer dementia with insufficient neuropathological changes: PRAD with insufficient AD lesions Serrano-Pozo, Alberto; Qian, Jing; Monsell, Sarah E. Annals of Neurology, Vol. 75, Issue 4 https://doi.org/10.1002/ana.24125	journal	April 2014
Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions Villemagne, Victor L.; Doré, Vincent; Burnham, Samantha C. Nature Reviews Neurology, Vol. 14, Issue 4 https://doi.org/10.1038/nrneurol.2018.9	journal	February 2018
Half-curcumin analogues as PET imaging probes for amyloid beta species Yang, Jian; Cheng, Ran; Fu, Hualong Chemical Communications, Vol. 55, Issue 25 https://doi.org/10.1039/c8cc10166c	journal	January 2019
Dementia spectrum disorders: lessons learnt from decades with PET research Wilson, Heather; Pagano, Gennaro; Politis, Marios Journal of Neural Transmission, Vol. 126, Issue 3 https://doi.org/10.1007/s00702-019-01975-4	journal	February 2019
Recent progress in the development of metal complexes as β-amyloid imaging probes in the brain Chen, Kaihua; Cui, Mengchao MedChemComm, Vol. 8, Issue 7 https://doi.org/10.1039/c7md00064b	journal	January 2017
Regional brain hypometabolism is unrelated to regional amyloid plaque burden Altmann, Andre; Ng, Bernard; Landau, Susan M. Brain, Vol. 138, Issue 12 https://doi.org/10.1093/brain/awv278	journal	September 2015
[ ¹⁸ F]flutemetamol amyloid positron emission tomography in preclinical and symptomatic Alzheimer's disease: Specific detection of advanced phases of amyloid-β pathology Thal, Dietmar Rudolf; Beach, Thomas G.; Zanette, Michelle Alzheimer's & Dementia, Vol. 11, Issue 8 https://doi.org/10.1016/j.jalz.2015.05.018	journal	July 2015
Appropriate use criteria for amyloid PET: A report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association Johnson, Keith A.; Minoshima, Satoshi; Bohnen, Nicolaas I. Alzheimer's & Dementia, Vol. 9, Issue 1 https://doi.org/10.1016/j.jalz.2013.01.002	journal	January 2013
Disclosure of amyloid imaging results to research participants: Has the time come? Lingler, Jennifer H.; Klunk, William E. Alzheimer's & Dementia, Vol. 9, Issue 6 https://doi.org/10.1016/j.jalz.2012.09.014	journal	February 2013
A kinetics-based approach to amyloid PET semi-quantification Chincarini, A.; Peira, E.; Corosu, M. European Journal of Nuclear Medicine and Molecular Imaging, Vol. 47, Issue 9 https://doi.org/10.1007/s00259-020-04689-y	journal	January 2020
Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer’s disease Pascoal, T. A.; Mathotaarachchi, S.; Mohades, S. Molecular Psychiatry, Vol. 22, Issue 2 https://doi.org/10.1038/mp.2016.37	journal	March 2016
Factors affecting Aβ plasma levels and their utility as biomarkers in ADNI Toledo, Jon B.; Vanderstichele, Hugo; Figurski, Michal Acta Neuropathologica, Vol. 122, Issue 4 https://doi.org/10.1007/s00401-011-0861-8	journal	July 2011
Molecular imaging in dementia: Past, present, and future Laforce, Robert; Soucy, Jean-Paul; Sellami, Leila Alzheimer's & Dementia, Vol. 14, Issue 11 https://doi.org/10.1016/j.jalz.2018.06.2855	journal	July 2018
Evaluation of PiB visual interpretation with CSF Aβ and longitudinal SUVR in J-ADNI study Okada, Yusuke; Kato, Takashi; Iwata, Kaori Annals of Nuclear Medicine, Vol. 34, Issue 2 https://doi.org/10.1007/s12149-019-01420-2	journal	November 2019
Update on biomarkers for amyloid pathology in Alzheimer's disease Ashton, Nicholas J.; Schöll, Michael; Heurling, Kerstin Biomarkers in Medicine, Vol. 12, Issue 7 https://doi.org/10.2217/bmm-2017-0433	journal	July 2018
Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer’s disease Lehmann, Manja; Ghosh, Pia M.; Madison, Cindee Brain, Vol. 136, Issue 3 https://doi.org/10.1093/brain/aws327	journal	January 2013
Amyloid imaging in mild cognitive impairment subtypes Wolk, David A.; Price, Julie C.; Saxton, Judy A. Annals of Neurology, Vol. 65, Issue 5 https://doi.org/10.1002/ana.21598	journal	May 2009
Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimerâ€™s disease Canobbio, Ilaria; Abubaker, Aisha Alsheikh; Visconte, Caterina Frontiers in Cellular Neuroscience, Vol. 9 https://doi.org/10.3389/fncel.2015.00065	journal	March 2015
Amyloid imaging in the differential diagnosis of dementia: review and potential clinical applications Laforce, Robert; Rabinovici, Gil D. Alzheimer's Research & Therapy, Vol. 3, Issue 6 https://doi.org/10.1186/alzrt93	journal	November 2011
Preventive immunization of aged and juvenile non-human primates to beta-amyloid Kofler, Julia; Lopresti, Brian; Janssen, Chris Journal of Neuroinflammation, Vol. 9, Issue 1 https://doi.org/10.1186/1742-2094-9-84	journal	May 2012
Quantitative structural MRI for early detection of Alzheimer’s disease McEvoy, Linda K.; Brewer, James B. Expert Review of Neurotherapeutics, Vol. 10, Issue 11 https://doi.org/10.1586/ern.10.162	journal	November 2010
Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment Chandra, Avinash; Valkimadi, Polytimi‐Eleni; Pagano, Gennaro Human Brain Mapping, Vol. 40, Issue 18 https://doi.org/10.1002/hbm.24782	journal	August 2019
NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease Jack, Clifford R.; Bennett, David A.; Blennow, Kaj Alzheimer's & Dementia, Vol. 14, Issue 4 https://doi.org/10.1016/j.jalz.2018.02.018	journal	April 2018
Comparison of 11C-PiB and 18F-florbetaben for Aβ imaging in ageing and Alzheimer’s disease Villemagne, Victor L.; Mulligan, Rachel S.; Pejoska, Svetlana European Journal of Nuclear Medicine and Molecular Imaging, Vol. 39, Issue 6 https://doi.org/10.1007/s00259-012-2088-x	journal	March 2012
[18F]Flutemetamol amyloid-beta PET imaging compared with [11C]PIB across the spectrum of Alzheimer’s disease Hatashita, Shizuo; Yamasaki, Hidetomo; Suzuki, Yutaka European Journal of Nuclear Medicine and Molecular Imaging, Vol. 41, Issue 2 https://doi.org/10.1007/s00259-013-2564-y	journal	October 2013
Preclinical Evaluation of [18F]THK-5105 Enantiomers: Effects of Chirality on Its Effectiveness as a Tau Imaging Radiotracer Tago, Tetsuro; Furumoto, Shozo; Okamura, Nobuyuki Molecular Imaging and Biology, Vol. 18, Issue 2 https://doi.org/10.1007/s11307-015-0879-8	journal	July 2015
Hippocampal Endosomal, Lysosomal, and Autophagic Dysregulation in Mild Cognitive Impairment: Correlation With Aβ and Tau Pathology Perez, Sylvia E.; He, Bin; Nadeem, Muhammad Journal of Neuropathology & Experimental Neurology, Vol. 74, Issue 4 https://doi.org/10.1097/nen.0000000000000179	journal	April 2015
[¹⁸F]-Florbetapir PET: Towards Predicting Dementia in Adults with Down Syndrome Keator, David B.; Doran, Eric; Van Erp, Theo G. M. https://doi.org/10.1101/235440	posted_content	February 2018
Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes Tan, Rachel H.; Kril, Jillian J.; Yang, Yue Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol. 9, Issue 1 https://doi.org/10.1016/j.dadm.2017.05.005	journal	January 2017
Relationships between Beta-Amyloid and Functional Connectivity in Different Components of the Default Mode Network in Aging Mormino, Elizabeth C.; Smiljic, Andre; Hayenga, Amynta O. Cerebral Cortex, Vol. 21, Issue 10 https://doi.org/10.1093/cercor/bhr025	journal	March 2011
Brain tissue Aβ42 levels are linked to shunt response in idiopathic normal pressure hydrocephalus Abu Hamdeh, Sami; Virhammar, Johan; Sehlin, Dag Journal of Neurosurgery, Vol. 130, Issue 1 https://doi.org/10.3171/2017.7.jns171005	journal	January 2018
Increased metabolic vulnerability in early-onset Alzheimer’s disease is not related to amyloid burden Rabinovici, Gil D.; Furst, Ansgar J.; Alkalay, Adi Brain, Vol. 133, Issue 2 https://doi.org/10.1093/brain/awp326	journal	January 2010
The correlation between striatal and cortical binding ratio of 11C-PiB-PET in amyloid-uptake-positive patients Sauerbeck, Julia; Ishii, Kazunari; Hosokawa, Chisa Annals of Nuclear Medicine, Vol. 32, Issue 6 https://doi.org/10.1007/s12149-018-1258-8	journal	May 2018
Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases Erkkinen, Michael G.; Kim, Mee-Ohk; Geschwind, Michael D. Cold Spring Harbor Perspectives in Biology, Vol. 10, Issue 4 https://doi.org/10.1101/cshperspect.a033118	journal	July 2017
Neuroimaging of Alzheimer’s disease: focus on amyloid and tau PET Matsuda, Hiroshi; Shigemoto, Yoko; Sato, Noriko Japanese Journal of Radiology, Vol. 37, Issue 11 https://doi.org/10.1007/s11604-019-00867-7	journal	September 2019
In vivo demonstration of amyloid burden in posterior cortical atrophy: a case series with PET and CSF findings Formaglio, Maïté; Costes, Nicolas; Seguin, Jérémie Journal of Neurology, Vol. 258, Issue 10 https://doi.org/10.1007/s00415-011-6030-0	journal	April 2011
Alzheimer's disease: The next frontier—Special Report 2017 Karlawish, Jason; Jack, Clifford R.; Rocca, Walter A. Alzheimer's & Dementia, Vol. 13, Issue 4 https://doi.org/10.1016/j.jalz.2017.02.006	journal	April 2017
PET and CSF amyloid-β status are differently predicted by patient features: information from discordant cases Reimand, Juhan; de Wilde, Arno; Teunissen, Charlotte E. Alzheimer's Research & Therapy, Vol. 11, Issue 1 https://doi.org/10.1186/s13195-019-0561-5	journal	December 2019
Interaction of the amyloid imaging tracer FDDNP with hallmark Alzheimer’s disease pathologies Thompson, Paul W.; Ye, Liang; Morgenstern, Jennifer L. Journal of Neurochemistry, Vol. 109, Issue 2 https://doi.org/10.1111/j.1471-4159.2009.05996.x	journal	April 2009
Biomarkers for the Early Detection and Progression of Alzheimer’s Disease Counts, Scott E.; Ikonomovic, Milos D.; Mercado, Natosha Neurotherapeutics, Vol. 14, Issue 1 https://doi.org/10.1007/s13311-016-0481-z	journal	October 2016
Dementia of the Alzheimer Type Jalbert, J. J.; Daiello, L. A.; Lapane, K. L. Epidemiologic Reviews, Vol. 30, Issue 1 https://doi.org/10.1093/epirev/mxn008	journal	May 2008
Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid Braak, Heiko; Zetterberg, Henrik; Del Tredici, Kelly Acta Neuropathologica, Vol. 126, Issue 5 https://doi.org/10.1007/s00401-013-1139-0	journal	June 2013
Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia Perez, Sylvia E.; Miguel, Jennifer C.; He, Bin Acta Neuropathologica, Vol. 137, Issue 3 https://doi.org/10.1007/s00401-019-01965-6	journal	February 2019
Detection of brain amyloid β deposition in patients with neuropsychological impairment after traumatic brain injury: PET evaluation using Pittsburgh Compound-B Kawai, Nobuyuki; Kawanishi, Masahiko; Kudomi, Nobuyuki Brain Injury, Vol. 27, Issue 9 https://doi.org/10.3109/02699052.2013.794963	journal	May 2013
Subtypes of progressive aphasia: application of the international consensus criteria and validation using β-amyloid imaging Leyton, Cristian E.; Villemagne, Victor L.; Savage, Sharon Brain, Vol. 134, Issue 10 https://doi.org/10.1093/brain/awr216	journal	September 2011
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease Ikonomovic, M. D. Brain: A Journal of Neurology, Vol. 131, Issue 1630-1645 https://doi.org/10.3410/f.1115351.571370	journal	January 2008
Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition Bugg, Julie M. Archives of Neurology, Vol. 69, Issue 5 https://doi.org/10.1001/archneurol.2011.845	journal	May 2012
Nonlinear Association Between Cerebrospinal Fluid and Florbetapir F-18 β-Amyloid Measures Across the Spectrum of Alzheimer Disease Toledo, Jon B.; Bjerke, Maria; Da, Xiao JAMA Neurology, Vol. 72, Issue 5 https://doi.org/10.1001/jamaneurol.2014.4829	journal	May 2015
A metabolomic approach to identifying biomarkers in blood of Alzheimer's disease Lin, Chia‐Ni; Huang, Chin‐Chang; Huang, Kuo‐Lun Annals of Clinical and Translational Neurology, Vol. 6, Issue 3 https://doi.org/10.1002/acn3.726	journal	February 2019
Amyloid-β imaging with PET in Alzheimer’s disease: is it feasible with current radiotracers and technologies? Moghbel, Mateen C.; Saboury, Babak; Basu, Sandip European Journal of Nuclear Medicine and Molecular Imaging, Vol. 39, Issue 2 https://doi.org/10.1007/s00259-011-1960-4	journal	October 2011
Brain uptake and safety of Flutemetamol F 18 injection in Japanese subjects with probable Alzheimer’s disease, subjects with amnestic mild cognitive impairment and healthy volunteers Miki, Takami; Shimada, Hiroyuki; Kim, Jae-Seung Annals of Nuclear Medicine, Vol. 31, Issue 3 https://doi.org/10.1007/s12149-017-1154-7	journal	February 2017
PET amyloid-beta imaging in preclinical Alzheimer's disease Vlassenko, Andrei G.; Benzinger, Tammie L. S.; Morris, John C. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1822, Issue 3 https://doi.org/10.1016/j.bbadis.2011.11.005	journal	March 2012
A systematic review and meta‐analysis of ¹⁸ F‐labeled amyloid imaging in Alzheimer's disease Yeo, Jing Ming; Waddell, Briony; Khan, Zubair Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol. 1, Issue 1 https://doi.org/10.1016/j.dadm.2014.11.004	journal	March 2015
Molecular imaging: What is right and what is an illusion? Klunk, William E. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol. 10, Issue 1 https://doi.org/10.1016/j.dadm.2018.01.004	journal	January 2018
Cortical phase changes in Alzheimer's disease at 7T MRI: A novel imaging marker van Rooden, Sanneke; Versluis, Maarten J.; Liem, Michael K. Alzheimer's & Dementia, Vol. 10, Issue 1 https://doi.org/10.1016/j.jalz.2013.02.002	journal	May 2013
ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide Thompson, Paul M.; Andreassen, Ole A.; Arias-Vasquez, Alejandro NeuroImage, Vol. 145 https://doi.org/10.1016/j.neuroimage.2015.11.057	journal	January 2017
Integration and relative value of biomarkers for prediction of MCI to AD progression: Spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers Da, Xiao; Toledo, Jon B.; Zee, Jarcy NeuroImage: Clinical, Vol. 4 https://doi.org/10.1016/j.nicl.2013.11.010	journal	January 2014
Sugihara causality analysis of scalp EEG for detection of early Alzheimer's disease McBride, Joseph C.; Zhao, Xiaopeng; Munro, Nancy B. NeuroImage: Clinical, Vol. 7 https://doi.org/10.1016/j.nicl.2014.12.005	journal	January 2015
Comparison of [ 18 F]Flutemetamol and [ 11 C]Pittsburgh Compound-B in cognitively normal young, cognitively normal elderly, and Alzheimer's disease dementia individuals Lowe, Val J.; Lundt, Emily; Knopman, David NeuroImage: Clinical, Vol. 16 https://doi.org/10.1016/j.nicl.2017.08.011	journal	January 2017
Neuroimaging and other modalities to assess Alzheimer's disease in Down syndrome Neale, Natalie; Padilla, Concepcion; Fonseca, Luciana Mascarenhas NeuroImage: Clinical, Vol. 17 https://doi.org/10.1016/j.nicl.2017.10.022	journal	January 2018
Impact of partial volume correction on the regional correspondence between in vivo [C-11]PiB PET and postmortem measures of Aβ load Minhas, Davneet S.; Price, Julie C.; Laymon, Charles M. NeuroImage: Clinical, Vol. 19 https://doi.org/10.1016/j.nicl.2018.04.007	journal	January 2018
Utilizing the Centiloid scale in cross-sectional and longitudinal PiB PET studies Su, Yi; Flores, Shaney; Hornbeck, Russ C. NeuroImage: Clinical, Vol. 19 https://doi.org/10.1016/j.nicl.2018.04.022	journal	January 2018
Biomathematical screening of amyloid radiotracers with clinical usefulness index Nai, Ying-Hwey; Shidahara, Miho; Seki, Chie Alzheimer's & Dementia: Translational Research & Clinical Interventions, Vol. 3, Issue 4 https://doi.org/10.1016/j.trci.2017.08.006	journal	September 2017
Moderate‐ to high‐intensity exercise does not modify cortical β‐amyloid in Alzheimer's disease Frederiksen, Kristian S.; Madsen, Karine; Andersen, Birgitte B. Alzheimer's & Dementia: Translational Research & Clinical Interventions, Vol. 5, Issue 1 https://doi.org/10.1016/j.trci.2019.04.006	journal	January 2019
Cerebral white matter lesions – associations with Aβ isoforms and amyloid PET van Westen, Danielle; Lindqvist, Daniel; Blennow, Kaj Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep20709	journal	February 2016
Multiple imputation models should incorporate the outcome in the model of interest Bartlett, J. W.; Frost, C.; Carpenter, J. R. Brain, Vol. 134, Issue 11 https://doi.org/10.1093/brain/awr061	journal	June 2011
Chain Link Fence Impalements in a Traffic Accident Giusti, G. V.; Bacci, M. The American Journal of Forensic Medicine and Pathology, Vol. 7, Issue 2 https://doi.org/10.1097/00000433-198607020-00018	journal	June 1986
Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort Li, Jin; Zhang, Qiushi; Chen, Feng BioMed Research International, Vol. 2015 https://doi.org/10.1155/2015/647389	journal	January 2015
Preclinical Alzheimer disease: identification of cases at risk among cognitively intact older individuals Lazarczyk, Maciej J.; Hof, Patrick R.; Bouras, Constantin BMC Medicine, Vol. 10, Issue 1 https://doi.org/10.1186/1741-7015-10-127	journal	October 2012
Sex-specific risk of cardiovascular disease and cognitive decline: pregnancy and menopause Miller, Virginia M.; Garovic, Vesna D.; Kantarci, Kejal Biology of Sex Differences, Vol. 4, Issue 1 https://doi.org/10.1186/2042-6410-4-6	journal	January 2013
Diagnostic effectiveness of quantitative [18F]flutemetamol PET imaging for detection of fibrillar amyloid β using cortical biopsy histopathology as the standard of truth in subjects with idiopathic normal pressure hydrocephalus Leinonen, Ville; Rinne, Juha O.; Wong, Dean F. Acta Neuropathologica Communications, Vol. 2, Issue 1 https://doi.org/10.1186/2051-5960-2-46	journal	April 2014
Profiling of hepatic clearance pathways of Pittsburgh compound B and human liver cytochrome p450 phenotyping Van Vlaslaer, Anne; Mortishire-Smith, Russell J.; Mackie, Claire EJNMMI Research, Vol. 3, Issue 1 https://doi.org/10.1186/2191-219x-3-10	journal	February 2013
Assessing THK523 selectivity for tau deposits in Alzheimer’s disease and non–Alzheimer’s disease tauopathies Fodero-Tavoletti, Michelle T.; Furumoto, Shozo; Taylor, Leanne Alzheimer's Research & Therapy, Vol. 6, Issue 1 https://doi.org/10.1186/alzrt240	journal	January 2014
Molecular imaging in Alzheimer's disease: new perspectives on biomarkers for early diagnosis and drug development Nordberg, Agneta Alzheimer's Research & Therapy, Vol. 3, Issue 6 https://doi.org/10.1186/alzrt96	journal	January 2011
Gd-nanoparticles functionalization with specific peptides for ß-amyloid plaques targeting Plissonneau, Marie; Pansieri, Jonathan; Heinrich-Balard, Laurence Journal of Nanobiotechnology, Vol. 14, Issue 1 https://doi.org/10.1186/s12951-016-0212-y	journal	July 2016
Rates of -amyloid accumulation are independent of hippocampal neurodegeneration Jack, C. R.; Wiste, H. J.; Knopman, D. S. Neurology, Vol. 82, Issue 18 https://doi.org/10.1212/wnl.0000000000000386	journal	April 2014
Clinical Profile of PiB-Positive Corticobasal Syndrome Burrell, James R.; Hornberger, Michael; Villemagne, Victor L. PLoS ONE, Vol. 8, Issue 4 https://doi.org/10.1371/journal.pone.0061025	journal	April 2013
Potential Clinical Value of Multiparametric PET in the Prediction of Alzheimer’s Disease Progression Chen, Xueqi; Zhou, Yun; Wang, Rongfu PLOS ONE, Vol. 11, Issue 5 https://doi.org/10.1371/journal.pone.0154406	journal	May 2016
Blood protein predictors of brain amyloid for enrichment in clinical trials? Ashton, Nicholas J.; Kiddle, Steven J.; Graf, John Wiley https://doi.org/10.17863/cam.24065	journalarticle	January 2015
Type 2 diabetes as a risk factor for cognitive impairment: current insights Umegaki, Hiroyuki Clinical Interventions in Aging https://doi.org/10.2147/cia.s48926	journal	June 2014
General anesthetic and the risk of dementia in elderly patients: current insights Seitz, Dallas; Hussain, Maria; Eckenhoff, Roderic Clinical Interventions in Aging https://doi.org/10.2147/cia.s49680	journal	September 2014
Diagnosing Corticobasal Syndrome Based on the Presence of Visual Hallucinations and Imaging with Amyloid Positron Emission Tomography Nishida, Hiroshi; Hayashi, Yuichi; Harada, Naoko Internal Medicine, Vol. 57, Issue 4 https://doi.org/10.2169/internalmedicine.8534-16	journal	January 2018
Asymptomatic Alzheimers Disease: A Prodrome or a State of Resilience? Driscoll, I.; Troncoso, J. Current Alzheimer Research, Vol. 8, Issue 4 https://doi.org/10.2174/156720511795745348	journal	June 2011
Differentiating between Alzheimer Disease Patients and Controls with Phase-difference-enhanced Imaging at 3T: A Feasibility Study Tateishi, Machiko; Kitajima, Mika; Hirai, Toshinori Magnetic Resonance in Medical Sciences, Vol. 17, Issue 4 https://doi.org/10.2463/mrms.mp.2017-0134	journal	January 2018
Clinical Validation of ¹⁸F-AZD4694, an Amyloid-β–Specific PET Radioligand Cselényi, Zsolt; Jönhagen, Maria Eriksdotter; Forsberg, Anton Journal of Nuclear Medicine, Vol. 53, Issue 3 https://doi.org/10.2967/jnumed.111.094029	journal	February 2012
Imaging Biomarkers in Alzheimer’s Disease: A Practical Guide for Clinicians Sheikh-Bahaei, Nasim; Sajjadi, Seyed Ahmad; Manavaki, Roido Journal of Alzheimer's Disease Reports, Vol. 1, Issue 1 https://doi.org/10.3233/adr-170013	journal	July 2017
Early Postmenopausal Transdermal 17β-Estradiol Therapy and Amyloid-β Deposition Kantarci, Kejal; Lowe, Val J.; Lesnick, Timothy G. Journal of Alzheimer's Disease, Vol. 53, Issue 2 https://doi.org/10.3233/jad-160258	journal	July 2016
Negative 11C-PIB PET Predicts Lack of Alzheimer’s Disease Pathology in Postmortem Examination Scheinin, Noora M.; Gardberg, Maria; Röyttä, Matias Journal of Alzheimer's Disease, Vol. 63, Issue 1 https://doi.org/10.3233/jad-170569	journal	April 2018
Blood-brain transfer of Pittsburgh compound B in humans Gjedde, Albert; Aanerud, Joel; Braendgaard, Hans Frontiers in Aging Neuroscience, Vol. 5 https://doi.org/10.3389/fnagi.2013.00070	journal	January 2013
PiB Fails to Map Amyloid Deposits in Cerebral Cortex of Aged Dogs with Canine Cognitive Dysfunction Fast, Rikke; Rodell, Anders; Gjedde, Albert Frontiers in Aging Neuroscience, Vol. 5 https://doi.org/10.3389/fnagi.2013.00099	journal	January 2013
Cerebrospinal Fluid Levels of Amyloid Beta 1-43 Mirror 1-42 in Relation to Imaging Biomarkers of Alzheimer’s Disease Almdahl, Ina S.; Lauridsen, Camilla; Selnes, Per Frontiers in Aging Neuroscience, Vol. 9 https://doi.org/10.3389/fnagi.2017.00009	journal	February 2017
Biomarkers in Alzheimer’s Disease Riverol, Mario; López, Oscar L. Frontiers in Neurology, Vol. 2 https://doi.org/10.3389/fneur.2011.00046	journal	January 2011
Cerebral Microbleeds: A Review of Clinical, Genetic, and Neuroimaging Associations Yates, Paul A.; Villemagne, Victor L.; Ellis, Kathryn A. Frontiers in Neurology, Vol. 4 https://doi.org/10.3389/fneur.2013.00205	journal	January 2014
Role of Hybrid Brain Imaging in Neuropsychiatric Disorders Burhan, Amer; Marlatt, Nicole; Palaniyappan, Lena Diagnostics, Vol. 5, Issue 4 https://doi.org/10.3390/diagnostics5040577	journal	December 2015
Plasma-Enabled Carbon Nanostructures for Early Diagnosis of Neurodegenerative Diseases Pineda, Shafique; Han, Zhao; Ostrikov, Kostya Materials, Vol. 7, Issue 7 https://doi.org/10.3390/ma7074896	journal	June 2014
Cytokines and Cytokine Receptors Involved in the Pathogenesis of Alzheimers Disease Nagae, Tomone; Araki, Kiho Journal of Clinical & Cellular Immunology, Vol. 7, Issue 4 https://doi.org/10.4172/2155-9899.1000441	journal	January 2016
Prevalence of dementia in a rural nursing home population in Southern Germany Hutsteiner, P.; Galler, S.; Mendoza, M. C. The European Journal of Psychiatry, Vol. 27, Issue 3 https://doi.org/10.4321/s0213-61632013000300003	journal	September 2013
Developing Univariate Neurodegeneration Biomarkers with Low-Rank and Sparse Subspace Decomposition Wang, Gang; Dong, Qunxi; Wu, Jianfeng arXiv https://doi.org/10.48550/arxiv.2010.13954	text	January 2020
Prevalence of dementia in a rural nursing home population in southern Germany Hutsteiner, Petra Universität Regensburg https://doi.org/10.5283/epub.30103	text	January 2014
Amyloid Imaging PET Ligands as Biomarkers for Alzheimer’s Disease, Preclinical Evaluation Svedberg, Marie; Hellstrm-Lindahl, Ewa; Rahman, Obaidur Positron Emission Tomography - Current Clinical and Research Aspects https://doi.org/10.5772/31813	book	February 2012
Conceptual and Measurement Challenges in Research on Cognitive Reserve Jones, Richard; Manly, Jennifer J.; Glymour, M. Maria Columbia University https://doi.org/10.7916/d8pr97dh	text	January 2011

Similar Records

Regional correlations between [ 11 C]PIB PET and post-mortem burden of amyloid-beta pathology in a diverse neuropathological cohort

Journal Article · Sun Jan 01 00:00:00 EST 2017 · NeuroImage: Clinical · OSTI ID:1625298

Seo, Sang Won; Ayakta, Nagehan; Grinberg, Lea T.; +12 more

Distribution of precursor amyloid-. beta. -protein messenger RNA in human cerebral cortex: relationship to neurofibrillary tangles and neuritic plaques

Journal Article · Tue Mar 01 00:00:00 EST 1988 · Proc. Natl. Acad. Sci. U.S.A.; (United States) · OSTI ID:1625298

Lewis, D A; Higgins, G A; Young, W G; +4 more

¹⁸F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes

Journal Article · Thu Jan 31 00:00:00 EST 2019 · Alzheimer's Research & Therapy · OSTI ID:1625298

Tsai, Richard M.; Bejanin, Alexandre; Lesman-Segev, Orit; +21 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
neurosciences & neurology
Pittsburgh Compound-B
PiB
amyloid imaging
plaques
PET imaging

Title: Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

Citation Formats

References (62)

Cited By (181)

Similar Records

Related Subjects