A traditional evolutionary history of foot-and-mouth disease viruses in Southeast Asia challenged by analyses of non-structural protein coding sequences

Brito, Barbara; Pauszek, Steven J.; Hartwig, Ethan J.; Smoliga, George R.; Vu, Le T.; Dong, Pham V.; Stenfeldt, Carolina; Rodriguez, Luis L.; King, Donald P.; Knowles, Nick J.; Bachanek-Bankowska, Katarzyna; Long, Ngo T.; Dung, Do H.; Arzt, Jonathan

doi:10.1038/s41598-018-24870-6

Title: A traditional evolutionary history of foot-and-mouth disease viruses in Southeast Asia challenged by analyses of non-structural protein coding sequences

Journal Article · Tue Apr 24 00:00:00 EDT 2018 · Scientific Reports

DOI:https://doi.org/10.1038/s41598-018-24870-6· OSTI ID:1624398

^[1]; Pauszek, Steven J. ^[2]; Hartwig, Ethan J. ^[2]; Smoliga, George R. ^[2]; Vu, Le T. ^[3]; Dong, Pham V. ^[3];

^[4]; Rodriguez, Luis L. ^[2]; King, Donald P. ^[5]; Knowles, Nick J. ^[5]; Bachanek-Bankowska, Katarzyna ^[5]; Long, Ngo T. ^[3]; Dung, Do H. ^[6];

^[2]

US Dept. of Homeland Security (DHS), Greenport, NY (United States). Plum Island Animal Disease Center. Foreign Animal Disease Research Unit; Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States). PIADC Research Participation Program
US Dept. of Homeland Security (DHS), Greenport, NY (United States). Plum Island Animal Disease Center. Foreign Animal Disease Research Unit
Ministry of Agriculture and Rural Development, Ho Chi Minh City (Vietnam). Dept. of Animal Health. Regional Animal Health Office No. 6
US Dept. of Homeland Security (DHS), Greenport, NY (United States). Plum Island Animal Disease Center. Foreign Animal Disease Research Unit; Univ. of Minnesota, St. Paul, MN (United States). College of Veterinary Medicine. Dept. of Veterinary Population Medicine
The Pirbright Inst., Surry (United Kingdom)
Ministry of Agriculture and Rural Development, Ho Chi Minh City (Vietnam). Dept. of Animal Health

Recombination of rapidly evolving RNA-viruses provides an important mechanism for diversifcation, spread, and emergence of new variants with enhanced ftness. Foot-and-mouth disease virus (FMDV) causes an important transboundary disease of livestock that is endemic to most countries in Asia and Africa. Maintenance and spread of FMDV are driven by periods of dominance of specifc viral lineages. Current understanding of the molecular epidemiology of FMDV lineages is generally based on the phylogenetic relationship of the capsid-encoding genes, with less attention to the process of recombination and evolution of non-structural proteins. In this study, the putative recombination breakpoints of FMDVs endemic to Southeast Asia were determined using full-open reading frame sequences. Subsequently, the lineages’ divergence times of recombination-free genome regions were estimated. These analyses revealed a close relationship between two of the earliest endemic viral lineages that appear unrelated when only considering the phylogeny of their capsid proteins. Contrastingly, one lineage, named O/CATHAY, known for having a particular host predilection (pigs) has evolved independently. Additionally, intra-lineage recombination occurred at diferent breakpoints compared to the inter-lineage process. These results provide new insights about FMDV recombination patterns and the evolutionary interdependence of FMDV serotypes and lineages.

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Research Organization:: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: SC0014664

OSTI ID:: 1624398

Journal Information:: Scientific Reports, Vol. 8, Issue 1; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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