Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach

Vance, Nicholas R.; Gakhar, Lokesh; Spies, M. Ashley

doi:10.1002/anie.201706959

Title: Allosteric Tuning of Caspase-7: A Fragment-Based Drug Discovery Approach

Journal Article · Sun Oct 22 00:00:00 EDT 2017 · Angewandte Chemie (International Edition)

DOI:https://doi.org/10.1002/anie.201706959· OSTI ID:1623486

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Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, 115 S Grand Ave Iowa City IA 52242 USA
Department of Biochemistry, College of Medicine, University of Iowa, 51 Newton Road Iowa City IA 52242 USA; Protein Crystallography Facility, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 51 Newton Road Iowa City IA 52242 USA
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, 115 S Grand Ave Iowa City IA 52242 USA; Department of Biochemistry, College of Medicine, University of Iowa, 51 Newton Road Iowa City IA 52242 USA

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1623486

Journal Information:: Angewandte Chemie (International Edition), Vol. 56, Issue 46; ISSN 1433-7851

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 8 works

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A three-stage biophysical screening cascade for fragment-based drug discovery Mashalidis, Ellene H.; Śledź, Paweł; Lang, Steffen Nature Protocols, Vol. 8, Issue 11 https://doi.org/10.1038/nprot.2013.130	journal	October 2013
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Caspase Allostery and Conformational Selection Clark, A. Clay Chemical Reviews, Vol. 116, Issue 11 https://doi.org/10.1021/acs.chemrev.5b00540	journal	January 2016
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation Thomsen, N. D.; Koerber, J. T.; Wells, J. A. Proceedings of the National Academy of Sciences, Vol. 110, Issue 21 https://doi.org/10.1073/pnas.1306759110	journal	May 2013
Fibrils Colocalize Caspase-3 with Procaspase-3 to Foster Maturation Zorn, Julie A.; Wolan, Dennis W.; Agard, Nicholas J. Journal of Biological Chemistry, Vol. 287, Issue 40 https://doi.org/10.1074/jbc.M112.386128	journal	August 2012
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Cited By (3)

Identification of FDA-approved drugs as novel allosteric inhibitors of human executioner caspases Krishna Deepak, R. N. V.; Abdullah, Ahmad; Talwar, Priti Proteins: Structure, Function, and Bioinformatics, Vol. 86, Issue 11 https://doi.org/10.1002/prot.25601	journal	October 2018
Proteases: Pivot Points in Functional Proteomics Verhamme, Ingrid M.; Leonard, Sarah E.; Perkins, Ray C. Functional Proteomics https://doi.org/10.1007/978-1-4939-8814-3_20	book	October 2018
Determination of the binding mechanism of histone deacetylase inhibitors Meyer-Almes, Franz-Josef Chemical Biology & Drug Design, Vol. 93, Issue 6 https://doi.org/10.1111/cbdd.13449	journal	December 2018

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