A computational thrombus formation model: application to an idealized two-dimensional aneurysm treated with bare metal coils

Horn, John D.; Maitland, Duncan J.; Hartman, Jonathan; Ortega, Jason M.

doi:10.1007/s10237-018-1059-y

Title: A computational thrombus formation model: application to an idealized two-dimensional aneurysm treated with bare metal coils

Journal Article · Fri Aug 03 00:00:00 EDT 2018 · Biomechanics and Modeling in Mechanobiology

DOI:https://doi.org/10.1007/s10237-018-1059-y· OSTI ID:1608532

Horn, John D. ^[1]; Maitland, Duncan J. ^[2]; Hartman, Jonathan ^[3]; Ortega, Jason M. ^[4]

Texas A & M Univ., College Station, TX (United States); Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Texas A & M Univ., College Station, TX (United States)
Kaiser Permanente Sacremento Medical Center, CA (United States)
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

Cardiovascular implantable devices alter the biofluid dynamics and biochemistry of the blood in which they are placed. These perturbations can lead to thrombus formation which may or may not be desired, depending on the application. In this work, a computational model is developed that couples biofluid dynamics and biochemistry to predict the clotting response of blood to such devices. The model consists of 28 advection–diffusion–reaction partial differential equations to track proteins in the blood involved in clotting and utilizes boundary flux terms to model the initiation of the intrinsic clotting pathway at thrombogenic device surfaces. We use this model to simulate the transient clot growth within a 2D idealized bifurcation aneurysm filled with various distributions of bare metal coils with similar packing densities. The clot model predicts initial clot formation to occur in areas along coil surfaces where flow is minimal and where time-averaged shear rates are the smallest. Among the six coil-filled aneurysm cases simulated, maximum thrombus occlusion ranged between 80.8 and 92.2% of the post-treatment aneurysm volume and was achieved 325–450 s after treatment. Finally, with further refinement and validation, the computational clotting model will be a valuable engineering tool for evaluating and comparing the relative performance of cardiovascular implantable devices.

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Research Organization:: Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA); National Institutes of Health (NIH)

Grant/Contract Number:: AC52-07NA27344; R01EB000462

OSTI ID:: 1608532

Report Number(s):: LLNL-JRNL-741998; 896338

Journal Information:: Biomechanics and Modeling in Mechanobiology, Vol. 17, Issue 6; ISSN 1617-7959

Publisher:: Springer NatureCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 5 works

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