Interparticle Interactions in Dilute Solutions of Polyelectrolyte Complex Micelles

Wu, Hao; Ting, Jeffrey M.; Weiss, Thomas M.; Tirrell, Matthew V.

doi:10.1021/acsmacrolett.9b00226

Title: Interparticle Interactions in Dilute Solutions of Polyelectrolyte Complex Micelles

Journal Article · Wed Jun 19 00:00:00 EDT 2019 · ACS Macro Letters

DOI:https://doi.org/10.1021/acsmacrolett.9b00226· OSTI ID:1560647

^[1];

^[2]; Weiss, Thomas M. ^[3]; Tirrell, Matthew V. ^[4]

Univ. of Chicago, IL (United States). Inst. for Molecular Engineering
Univ. of Chicago, IL (United States). Inst. for Molecular Engineering; Argonne National Lab. (ANL), Argonne, IL (United States)
SLAC National Accelerator Lab., Menlo Park, CA (United States)
IUniv. of Chicago, IL (United States). Inst. for Molecular Engineering; Argonne National Lab. (ANL), Argonne, IL (United States)

The application of dilute solutions of polyelectrolyte complex (PEC) micelles for delivering therapeutic nucleic acids into disease sites has gained momentum. This Letter reports a detailed characterization of PEC micelles in dilute solutions including their internal structures and the determination of the interparticle interactions. The polymer concentration ranges from 0.1 to 0.5 wt %, a regime where micelle–micelle interactions are infrequent. We employ synchrotron small-angle X-ray scattering (SAXS) to simultaneously probe the morphology, internal structure, and radius of gyration (R_g) of the self-assemblies formed by charged diblock polyelectrolytes and homopolyelectrolytes. The emerging appearance of the structure factor in SAXS profiles with the increasing polymer concentration demonstrates the presence of the repulsive intermicellar correlations, which is further confirmed by the differences between the “reciprocal R_g” estimated by Guinier approximation and the “real space R_g” determined by pair distribution functions. We find that the soft corona chains tethered on the surface of phase-separated complex domains are compressed when micelles come close to the point where a hard-sphere interaction takes over. These findings contribute to the fundamental understanding of the structure and space-filling constraints in the complexation-driven self-assemblies and advance the rational design of cationic polymer-based nonviral gene delivery vectors.

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Research Organization:: SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-76SF00515; 70NANB14H012

OSTI ID:: 1560647

Journal Information:: ACS Macro Letters, Vol. 8, Issue 7; ISSN 2161-1653

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 15 works

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