Versatility of the adenovirus-vectored foot-and-mouth disease vaccine platform across multiple foot-and-mouth disease virus serotypes and topotypes using a vaccine dose representative of the AdtA24 conditionally licensed vaccine

Barrera, José; Brake, David A.; Schutta, Christopher; Ettyreddy, Damodar; Kamicker, Barbara J.; Rasmussen, Max V.; Bravo de Rueda, Carla; Zurita, Mariceny; Pisano, Melia; Hurtle, William; Brough, Douglas E.; Butman, Bryan T.; Harper, Bruce G.; Neilan, John G.

doi:10.1016/j.vaccine.2018.10.031

Title: Versatility of the adenovirus-vectored foot-and-mouth disease vaccine platform across multiple foot-and-mouth disease virus serotypes and topotypes using a vaccine dose representative of the AdtA24 conditionally licensed vaccine

Journal Article · Sat Oct 13 00:00:00 EDT 2018 · Vaccine

DOI:https://doi.org/10.1016/j.vaccine.2018.10.031· OSTI ID:1494688

Barrera, José ^[1]; Brake, David A. ^[1]; Schutta, Christopher ^[1]; Ettyreddy, Damodar ^[2];

^[1]; Rasmussen, Max V. ^[1]; Bravo de Rueda, Carla ^[3]; Zurita, Mariceny ^[1]; Pisano, Melia ^[4]; Hurtle, William ^[1]; Brough, Douglas E. ^[2]; Butman, Bryan T. ^[2]; Harper, Bruce G. ^[1];

^[1]

Plum Island Animal Disease Center, Greenport, NY (United States)
GenVec, Inc., Gaithersburg, MD (United States)
Plum Island Animal Disease Center Research Participation Program, Oak Ridge, TN (United States). Oak Ridge Institute for Science and Education
Plum Island Animal Disease Center, Greenport, NY (United States); Plum Island Animal Disease Center Research Participation Program, Oak Ridge, TN (United States). Oak Ridge Institute for Science and Education

We investigated the serotype- and topotype versatility of a replication-deficient human adenovirus serotype 5 vectored foot-and-mouth disease (FMD) vaccine platform (AdtFMD). Sixteen AdtFMD recombinant subunit monovalent vaccines targeting twelve distinct FMD virus (FMDV) serotype/topotypes in FMD Regional Pools I-VII were constructed. The AdtA24 serotype conditionally licensed vaccine served as the basis for vaccine design and target dose for cattle clinical trials. Several vaccines contained an additional RGD motif genetic insertion in the adenovector fiber knob, and/or a full-length 2B gene insertion in the FMDV P1 gene cassette. In 13 of the 22 efficacy studies conducted, naïve control and AdtFMD vaccinated cattle were challenged intradermolingually at 2 weeks post-vaccination using a FMDV strain homologous to the AdtFMD vaccine strain. Each of the 16 AdtFMD vaccines were immunogenic based on the presence of homologous neutralizing antibodies in the serum of approximately 90% of total vaccinates (n = 375) on the day of challenge. Importantly, for 75% of vaccines tested, the effective dose that conferred 100% protection against clinical FMD was identical to or in some cases lower than, the minimum protective dose for the conditionally licensed AdtA24 vaccine formulated with ENABL® adjuvant. Results also confirmed the capability of the AdtFMD vaccine platform to differentiate infected from vaccinated animals (DIVA) across the five FMDV serotypes evaluated. Collectively, this comprehensive set of FMD cattle vaccine dose ranging studies highlights the serotype- and topotype versatility of the AdtFMD vaccine platform for further development, licensure, and application in FMD outbreak control and disease eradication efforts.

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Research Organization:: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-06OR23100; HSHQPD-07-X-00003; HSHQDC-14-F-00035; HSHQDC-8-C-00011; HSHQDC-12-C-00127

OSTI ID:: 1494688

Journal Information:: Vaccine, Vol. 36, Issue 48; ISSN 0264-410X

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 6 works

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References (35)

Use of a portable real-time reverse transcriptasepolymerase chain reaction assay for rapid detection of foot-and-mouth disease virus Callahan, Johnny D.; Brown, Fred; Osorio, Fernando A. Journal of the American Veterinary Medical Association, Vol. 220, Issue 11 https://doi.org/10.2460/javma.2002.220.1636	journal	June 2002
Recombinant human adenovirus-5 expressing capsid proteins of Indian vaccine strains of foot-and-mouth disease virus elicits effective antibody response in cattle Sreenivasa, B. P.; Mohapatra, J. K.; Pauszek, S. J. Veterinary Microbiology, Vol. 203 https://doi.org/10.1016/j.vetmic.2017.03.019	journal	May 2017
Adenovirus-vectored foot-and-mouth disease vaccine confers early and full protection against FMDV O1 Manisa in swine Fernandez-Sainz, Ignacio; Medina, Gisselle N.; Ramirez-Medina, Elizabeth Virology, Vol. 502 https://doi.org/10.1016/j.virol.2016.12.021	journal	February 2017
Emergence of Foot-and-Mouth Disease Virus SAT 2 in Egypt During 2012 Ahmed, H. A.; Salem, S. A. H.; Habashi, A. R. Transboundary and Emerging Diseases, Vol. 59, Issue 6 https://doi.org/10.1111/tbed.12015	journal	October 2012
Review of the Global Distribution of Foot-and-Mouth Disease Virus from 2007 to 2014 Brito, B. P.; Rodriguez, L. L.; Hammond, J. M. Transboundary and Emerging Diseases, Vol. 64, Issue 2 https://doi.org/10.1111/tbed.12373	journal	May 2015
Multiple efficacy studies of an adenovirus-vectored foot-and-mouth disease virus serotype A24 subunit vaccine in cattle using homologous challenge Schutta, Christopher; Barrera, José; Pisano, Melia Vaccine, Vol. 34, Issue 27 https://doi.org/10.1016/j.vaccine.2015.12.018	journal	June 2016
Efficacy of a high-potency multivalent foot-and-mouth disease virus vaccine in cattle against heterologous challenge with a field virus from the emerging A/ASIA/G-VII lineage Waters, Ryan; Ludi, Anna B.; Fowler, Veronica L. Vaccine, Vol. 36, Issue 14 https://doi.org/10.1016/j.vaccine.2018.02.016	journal	March 2018
Efficacy of a high quality O1/Campos foot-and-mouth disease vaccine upon challenge with a heterologous Korean O Mya98 lineage virus in pigs Galdo Novo, S.; Malirat, V.; Maradei, E. D. Vaccine, Vol. 36, Issue 12 https://doi.org/10.1016/j.vaccine.2018.02.015	journal	March 2018
Use of ENABL® adjuvant to increase the potency of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine Barrera, José; Schutta, Christopher; Pisano, Melia Vaccine, Vol. 36, Issue 8 https://doi.org/10.1016/j.vaccine.2018.01.026	journal	February 2018
DetailedAnalysis of the CD8 ⁺ T-Cell Response followingAdenovirusVaccination Yang, Teng Chih; Dayball, Kelley; Wan, Yong Hong Journal of Virology, Vol. 77, Issue 24 https://doi.org/10.1128/JVI.77.24.13407-13411.2003	journal	December 2003
The need for improved vaccines against foot-and-mouth disease de los Santos, Teresa; Diaz-San Segundo, Fayna; Rodriguez, Luis L. Current Opinion in Virology, Vol. 29 https://doi.org/10.1016/j.coviro.2018.02.005	journal	April 2018
Experimental infections using the foot-and-mouth disease virus O/JPN/2010 in animals administered a vaccine preserved for emergency use in Japan Fukai, Katsuhiko; Nishi, Tatsuya; Shimada, Nobuaki Journal of Veterinary Medical Science, Vol. 79, Issue 1 https://doi.org/10.1292/jvms.16-0482	journal	January 2017
Correction for LaRocco et al., A Continuous Bovine Kidney Cell Line Constitutively Expressing Bovine α _V β ₆ Integrin Has Increased Susceptibility to Foot-and-Mouth Disease Virus LaRocco, Michael; Krug, Peter W.; Kramer, Ed Journal of Clinical Microbiology, Vol. 53, Issue 2 https://doi.org/10.1128/JCM.03220-14	journal	January 2015
Development of Replication-Defective Adenovirus Serotype 5 Containing the Capsid and 3C Protease Coding Regions of Foot-and-Mouth Disease Virus as a Vaccine Candidate Mayr, Gregory A.; Chinsangaram, Jarasvech; Grubman, Marvin J. Virology, Vol. 263, Issue 2 https://doi.org/10.1006/viro.1999.9940	journal	October 1999
Protection to homologous and heterologous challenge in pigs immunized with vaccine against foot-and-mouth disease type O caused an epidemic in East Asia during 2010/2011 Park, Jeong-Nam; Lee, Seo-Yong; Chu, Jia-Qi Vaccine, Vol. 32, Issue 16 https://doi.org/10.1016/j.vaccine.2014.01.067	journal	April 2014
Global Foot-and-Mouth Disease Research Update and Gap Analysis: 2 - Epidemiology, Wildlife and Economics Knight-Jones, T. J. D.; Robinson, L.; Charleston, B. Transboundary and Emerging Diseases, Vol. 63 https://doi.org/10.1111/tbed.12522	journal	June 2016
Characterization of foot-and-mouth disease virus from outbreaks in Ecuador during 2009–2010 and cross-protection studies with the vaccine strain in use in the region Maradei, Eduardo; Perez Beascoechea, Claudia; Malirat, Viviana Vaccine, Vol. 29, Issue 46 https://doi.org/10.1016/j.vaccine.2011.08.120	journal	October 2011
An improved, rapid competitive ELISA using a novel conserved 3B epitope for the detection of serum antibodies to foot-and-mouth disease virus Chung, Chungwon J.; Clavijo, Alfonso; Bounpheng, Mangkey A. Journal of Veterinary Diagnostic Investigation, Vol. 30, Issue 5 https://doi.org/10.1177/1040638718779641	journal	June 2018
Update on epidemiology and control of Foot and Mouth Disease - A menace to international trade and global animal enterprise Depa, P.; Dimri, Umesh; Sharma, Mc Veterinary World, Vol. 5, Issue 11 https://doi.org/10.5455/vetworld.2012.693-703	journal	January 2012
Foot-and-Mouth Disease Impact on Smallholders - What Do We Know, What Don't We Know and How Can We Find Out More? Knight-Jones, T. J. D.; McLaws, M.; Rushton, J. Transboundary and Emerging Diseases, Vol. 64, Issue 4 https://doi.org/10.1111/tbed.12507	journal	May 2016
Safety profile of a replication-deficient human adenovirus-vectored foot-and-mouth disease virus serotype A24 subunit vaccine in cattle Barrera, J.; Brake, D. A.; Kamicker, B. J. Transboundary and Emerging Diseases, Vol. 65, Issue 2 https://doi.org/10.1111/tbed.12724	journal	October 2017
Epidemiology of the Foot-and-Mouth Disease Serotype O Epidemic of November 2010 to April 2011 in the Republic Of Korea Yoon, H.; Yoon, S. -S.; Kim, Y. -J. Transboundary and Emerging Diseases, Vol. 62, Issue 3 https://doi.org/10.1111/tbed.12109	journal	June 2013
Genetic characterisation of the recent foot-and-mouth disease virus subtype A/IRN/2005 Klein, Joern; Hussain, Manzoor; Ahmad, Munir Virology Journal, Vol. 4, Issue 1 https://doi.org/10.1186/1743-422X-4-122	journal	January 2007
Retrospective evaluation of foot-and-mouth disease vaccine effectiveness in Turkey Knight-Jones, T. J. D.; Bulut, A. N.; Gubbins, S. Vaccine, Vol. 32, Issue 16 https://doi.org/10.1016/j.vaccine.2014.01.071	journal	April 2014
Foot-and-Mouth Disease Virus Serotype A in Egypt Knowles, Nick J.; Wadsworth, Jemma; Reid, Scott M. Emerging Infectious Diseases, Vol. 13, Issue 10 https://doi.org/10.3201/eid1310.070252	journal	October 2007
Efficacy of a high potency O1 Manisa monovalent vaccine against heterologous challenge with a FMDV O Mya98 lineage virus in pigs 4 and 7 days post vaccination Wilna, Vosloo; Hong, Nguyen Thi Thu; Geoffrey, Fosgate T. Vaccine, Vol. 33, Issue 24 https://doi.org/10.1016/j.vaccine.2015.04.045	journal	June 2015
Protection induced by a commercial bivalent vaccine against Foot-and-Mouth Disease 2010 field virus from Ecuador Duque, Hernando; Naranjo, Jose; Carrillo, Consuelo Vaccine, Vol. 34, Issue 35 https://doi.org/10.1016/j.vaccine.2016.06.073	journal	July 2016
Multimodel Inference: Understanding AIC and BIC in Model Selection Burnham, Kenneth P.; Anderson, David R. Sociological Methods & Research, Vol. 33, Issue 2 https://doi.org/10.1177/0049124104268644	journal	November 2004
Delivery of a foot-and-mouth disease virus empty capsid subunit antigen with nonstructural protein 2B improves protection of swine Pena, Lindomar; Moraes, Mauro Pires; Koster, Marla Vaccine, Vol. 26, Issue 45 https://doi.org/10.1016/j.vaccine.2008.08.022	journal	October 2008
Longevity of protection in cattle following immunisation with emergency FMD A22 serotype vaccine from the UK strategic reserve Cox, Sarah J.; Veronica Carr, B.; Parida, Satya Vaccine, Vol. 28, Issue 11 https://doi.org/10.1016/j.vaccine.2009.12.065	journal	March 2010
Evaluation of a Fiber-Modified Adenovirus Vector Vaccine against Foot-and-Mouth Disease in Cattle Medina, Gisselle N.; Montiel, Nestor; Diaz-San Segundo, Fayna Clinical and Vaccine Immunology, Vol. 23, Issue 2 https://doi.org/10.1128/CVI.00426-15	journal	November 2015
Selection of vaccine strains for serotype O foot-and-mouth disease viruses (2007–2012) circulating in Southeast Asia, East Asia and Far East Mahapatra, Mana; Upadhyaya, Sasmita; Aviso, Sharie Vaccine, Vol. 35, Issue 51 https://doi.org/10.1016/j.vaccine.2017.10.099	journal	December 2017
Protective effects of high-potency FMDV O 1 Manisa monovalent vaccine in cattle challenged with FMDV O/SKR/2010 at 7 or 4 days post vaccination Horsington, Jacquelyn; Perez, Claudia Beascoechea; Maradei, Eduardo Vaccine, Vol. 35, Issue 38 https://doi.org/10.1016/j.vaccine.2017.07.102	journal	September 2017
Recent Spread of a New Strain (A-Iran-05) of Foot-and-Mouth Disease Virus Type A in the Middle East Knowles, N. J.; Nazem Shirazi, M. H.; Wadsworth, J. Transboundary and Emerging Diseases, Vol. 56, Issue 5 https://doi.org/10.1111/j.1865-1682.2009.01074.x	journal	June 2009
A gene transfer vector-cell line system for complete functional complementation of adenovirus early regions E1 and E4 Brough, D. E.; Lizonova, A.; Hsu, C. Journal of Virology, Vol. 70, Issue 9 https://doi.org/10.1128/jvi.70.9.6497-6501.1996	journal	September 1996

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59 BASIC BIOLOGICAL SCIENCES
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