Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines
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journal
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February 2016 |
Efficient p53 Activation and Apoptosis by Simultaneous Disruption of Binding to MDM2 and MDMX
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journal
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September 2007 |
Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency
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journal
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April 2012 |
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
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journal
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October 2016 |
Structure of Bax
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journal
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November 2000 |
Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1
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journal
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June 2017 |
Bcl-2 family proteins and cancer
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journal
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October 2008 |
A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53
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journal
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November 2010 |
The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer
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journal
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June 2010 |
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
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journal
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December 2013 |
Targeted Disruption of the BCL9/ -Catenin Complex Inhibits Oncogenic Wnt Signaling
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journal
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August 2012 |
Structure of the Stapled p53 Peptide Bound to Mdm2
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journal
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December 2011 |
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
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journal
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November 2006 |
Distinct BimBH3 (BimSAHB) Stapled Peptides for Structural and Cellular Studies
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journal
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January 2014 |
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
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journal
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November 2006 |
Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices
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journal
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August 2016 |
Phage Selection of Photoswitchable Peptide Ligands
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journal
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April 2014 |
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
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journal
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January 2012 |
Small molecule Mcl-1 inhibitors for the treatment of cancer
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journal
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January 2015 |
The landscape of somatic copy-number alteration across human cancers
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journal
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February 2010 |
Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes
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journal
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July 2010 |
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
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journal
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May 2005 |
Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix
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journal
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September 2004 |
BH3 Profiling Identifies Three Distinct Classes of Apoptotic Blocks to Predict Response to ABT-737 and Conventional Chemotherapeutic Agents
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journal
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August 2007 |
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia
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journal
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January 2016 |
Development of a lytic peptide derived from BH3-only proteins
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journal
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March 2016 |
A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers
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journal
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June 2012 |
Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane
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journal
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November 2002 |
A General Framework for Development and Data Analysis of Competitive High-Throughput Screens for Small-Molecule Inhibitors of Protein−Protein Interactions by Fluorescence Polarization †
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journal
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December 2004 |
Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function
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journal
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February 2005 |
Programmed Anuclear Cell Death Delimits Platelet Life Span
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journal
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March 2007 |
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
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journal
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January 2013 |
Design and Structure of Stapled Peptides Binding to Estrogen Receptors
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journal
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June 2011 |
An All-Hydrocarbon Cross-Linking System for Enhancing the Helicity and Metabolic Stability of Peptides
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journal
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June 2000 |
Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains
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journal
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February 2016 |
Mcl-1- Bim complexes accommodate surprising point mutations via minor structural changes
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journal
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January 2010 |
Mitochondria—Judges and Executioners of Cell Death Sentences
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journal
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March 2016 |
Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members
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journal
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September 2015 |
Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer
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journal
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June 2015 |
Designing helical peptide inhibitors of protein–protein interactions
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journal
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August 2016 |
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
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journal
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January 2015 |
BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics
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journal
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July 2015 |
A Stapled BID BH3 Helix Directly Binds and Activates BAX
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journal
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October 2006 |
Features and development of Coot
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journal
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March 2010 |
Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide
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journal
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March 2007 |
BAX activation is initiated at a novel interaction site
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journal
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October 2008 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution
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journal
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January 2010 |
Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1
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journal
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October 2016 |
Phase I trial of a novel stapled peptide ALRN-6924 disrupting MDMX- and MDM2-mediated inhibition of WT p53 in patients with solid tumors and lymphomas.
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journal
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May 2017 |
Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
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journal
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August 2013 |
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
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journal
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May 2006 |
iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry
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journal
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July 2016 |
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
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journal
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March 2011 |
Potent and Specific Peptide Inhibitors of Human Pro-Survival Protein Bcl-xL
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journal
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March 2015 |
Mechanistic validation of a clinical lead stapled peptide that reactivates p53 by dual HDM2 and HDMX targeting
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journal
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October 2016 |
Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress: Miniperspective
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journal
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March 2014 |
Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53
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journal
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January 2014 |
Novel Bcl-2 Homology-3 Domain-like Sequences Identified from Screening Randomized Peptide Libraries for Inhibitors of the Pro-survival Bcl-2 Proteins
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journal
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September 2009 |
Bruton’s tyrosine kinase inhibition increases BCL-2 dependence and enhances sensitivity to venetoclax in chronic lymphocytic leukemia
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journal
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January 2017 |
Designed BH3 Peptides with High Affinity and Specificity for Targeting Mcl-1 in Cells
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journal
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July 2014 |
Hydrophile scanning as a complement to alanine scanning for exploring and manipulating protein-protein recognition: Application to the Bim BH3 domain
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journal
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July 2008 |
Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xL
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journal
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May 2010 |
Precision medicine in acute lymphoblastic leukemia
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journal
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October 2020 |
PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome
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journal
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December 2019 |
Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation
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journal
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February 2021 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution.
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