Human genetic marker for resistance to radiations and chemicals. 1997 annual progress report
'The specific aims listed in the original application will essentially be pursued as indicated. The major goal of the grant is to characterize a human homologue of the fission yeast Schizosaccharomyces pombe rad9 checkpoint control, radioresistance and chemoresistance gene, which is called HRAD9. The purpose is to gain information about the gene, including its structure and function, such that it can potentially be developed as a human genetic marker indicative of hypersensitivity to the deleterious effects associated with exposure to radiations or certain chemicals. The specific aims are divided into two major sections. The first section includes experiments designed to characterize the HRAD9 gene at the molecular level. Specifically, the genomic version of the gene will be isolated and its DNA sequence determined, in vitro mutagenesis will be used to assess structure/function relationships, and expression in cells and tissues will be examined. The second major set of aims focuses on determining the role of HRAD9 in radio/chemoresponsiveness and cancer. For this aim, human HRAD9 mutants will be constructed and characterized. In addition, the status of HRAD9 in cancer cells and tissues will be assessed.'
- Research Organization:
- Columbia Univ., New York, NY (US)
- Sponsoring Organization:
- USDOE Office of Environmental Management (EM), Office of Science and Risk Policy
- DOE Contract Number:
- FG07-96ER62309
- OSTI ID:
- 13593
- Report Number(s):
- EMSP-55100-97; ON: DE00013593
- Country of Publication:
- United States
- Language:
- English
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Human Genetic Marker for Resistance to Radiations and Chemicals
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