Magnetic/NIR-responsive drug carrier, multicolor cell imaging, and enhanced photothermal therapy of gold capped magnetite-fluorescent carbon hybrid nanoparticles

Wang, Hui; Cao, Guixin; Gai, Zheng; Hong, Kunlun; Banerjee, Probal; Zhou, Shuiqin

doi:10.1039/C4NR07335E

Title: Magnetic/NIR-responsive drug carrier, multicolor cell imaging, and enhanced photothermal therapy of gold capped magnetite-fluorescent carbon hybrid nanoparticles

Journal Article · Wed Mar 25 00:00:00 EDT 2015 · Nanoscale

DOI:https://doi.org/10.1039/C4NR07335E· OSTI ID:1279420

Wang, Hui ^[1]; Cao, Guixin ^[2]; Gai, Zheng ^[2]; Hong, Kunlun ^[2]; Banerjee, Probal ^[1]; Zhou, Shuiqin ^[1]

City Univ. (CUNY), Staten Island, NY (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

In our paper reports a type of multifunctional hybrid nanoparticle (NP) composed of gold nanocrystals coated on and/or embedded in a magnetite-fluorescent porous carbon core-shell NP template (Fe₃O₄@PC-CDs-Au) for biomedical applications, including magnetic/NIR-responsive drug release, multicolor cell imaging, and enhanced photothermal therapy. The synthesis of the Fe₃O₄@PC-CDs-Au NPs firstly involves the preparation of core-shell template NPs with magnetite nanocrystals clustered in the cores and fluorescent carbon dots (CDs) embedded in a porous carbon shell, followed by an in situ reduction of silver ions (Ag⁺) loaded in the porous carbon shell and a subsequent replacement of Ag NPs with Au NPs through a galvanic replacement reaction using HAuCl₄ as a precursor. Moreover, the Fe₃O₄@PC-CDsAu NPs can enter the intracellular region and light up mouse melanoma B16F10 cells in multicolor mode. The porous carbon shell, anchored with hydrophilic hydroxyl/carboxyl groups, endows the Fe₃O₄@PC-CDs-Au NPs with excellent stability in the aqueous phase and a high loading capacity (719 mg g^-1) for the anti-cancer drug doxorubicin (DOX). The superparamagnetic Fe₃O₄@PC-CDs-Au NPs with a saturation magnetization of 23.26 emu g^-1 produce localized heat under an alternating magnetic field, which triggers the release of the loaded drug. The combined photothermal effects of the Au nanocrystals and the CDs on/in the carbon shell can not only regulate the release rate of the loaded drug, but also efficiently kill tumor cells under NIR irradiation. Finally, in benefitting from their excellent optical properties, their magnetic field and NIR light-responsive drug release capabilities and their enhanced photothermal effect, such nanostructured Fe₃O₄@PC-CDs-Au hybrid NPs are very promising for simultaneous imaging diagnostics and high efficacy therapy.

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Research Organization:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC05-00OR22725; 1-12-BS-243; 66076-00 44

OSTI ID:: 1279420

Journal Information:: Nanoscale, Vol. 7, Issue 17; ISSN 2040-3364

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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