Mechanism for Clastogenic Activity of Naphthalene

Technical Report · Tue Sep 29 00:00:00 EDT 2015

DOI:https://doi.org/10.2172/1226965· OSTI ID:1226965

Buchholz, Bruce A. ^[1]

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1. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

Naphthalene incubations form DNA adducts in vitro in a dose dependent manner in both mouse and rat tissues. Rodent tissue incubations with naphthalene indicate that naphthalene forms as many DNA adducts as Benzo(a)pyrene, a known DNA binding carcinogen. The mouse airway has the greatest number of DNA adducts, corresponding to the higher metabolic activation of naphthalene in this location. Both rat tissues, the rat olfactory (tumor target) and the airways (non-tumor target), have similar levels of NA-DNA adducts, indicating that short term measures of initial adduct formation do not directly correlate with sites of tumor formation in the NTP bioassays.

• Research Organization: Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC52-07NA27344
• OSTI ID: 1226965
• Report Number(s): LLNL-TR-677645
• Country of Publication: United States
• Language: English

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