Diagnosis and assessment of skeletal related disease using calcium 41

Hillegonds, Darren J; Vogel, John S; Fitzgerald, Robert L; Deftos, Leonard J; Herold, David; Burton, Douglas W

Title: Diagnosis and assessment of skeletal related disease using calcium 41

Patent · Tue May 15 00:00:00 EDT 2012

OSTI ID:1042648

Hillegonds, Darren J ^[1]; Vogel, John S ^[2]; Fitzgerald, Robert L ^[3]; Deftos, Leonard J ^[4]; Herold, David ^[4]; Burton, Douglas W ^[5]

Oakland, CA
San Jose, CA
Encinitas, CA
Del Mar, CA
San Diego, CA

A method of determining calcium metabolism in a patient comprises the steps of administering radioactive calcium isotope .sup.41Ca to the patient, allowing a period of time to elapse sufficient for dissemination and reaction of the radioactive calcium isotope .sup.41Ca by the patient, obtaining a sample of the radioactive calcium isotope .sup.41Ca from the patient, isolating the calcium content of the sample in a form suitable for precise measurement of isotopic calcium concentrations, and measuring the calcium content to determine parameters of calcium metabolism in the patient.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: W-7405-ENG-48

Assignee:: Lawrence Livermore National Security, LLC (Livermore, CA); The Regents of the University of California (Oakland, CA)

Patent Number(s):: 8,178,076

Application Number:: 11/283,034

OSTI ID:: 1042648

Country of Publication:: United States

Language:: English

References (13)

Calcium-41 as a long-term biological tracer for bone resorption Elmore, David; Bhattacharyya, Maryka H.; Sacco-Gibson, Nancy Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 52, Issue 3-4 https://doi.org/10.1016/0168-583X(90)90471-6	journal	December 1990
High-throughput measurement of 41Ca by accelerator mass spectrometry to quantitate small changes in individual human bone turnover rates Hillegonds, D. Journal of the Association for Laboratory Automation, Vol. 9, Issue 3 https://doi.org/10.1016/j.jala.2004.04.015	journal	June 2004
Protocol for assessing bone health in humans by tracing long-lived 41Ca isotope in urine, serum, and saliva samples Lin, Yumei; Hillegonds, Darren J.; Gertz, Erik R. Analytical Biochemistry, Vol. 332, Issue 1 https://doi.org/10.1016/j.ab.2004.05.019	journal	September 2004
41Ca and Accelerator Mass Spectrometry to Monitor Calcium Metabolism in End Stage Renal Disease Patients Fitzgerald, Robert L.; Hillegonds, Darren J.; Burton, Douglas W. Clinical Chemistry, Vol. 51, Issue 11 https://doi.org/10.1373/clinchem.2005.049650	journal	November 2005
The study of skeletal calcium metabolism with 41Ca and 45Ca Freeman, Stewart P. H. T.; Beck, Belinda; Bierman, June M. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 172, Issue 1-4 https://doi.org/10.1016/S0168-583X(00)00341-4	journal	October 2000
Calcium metabolism in renal failure David, David S. The American Journal of Medicine, Vol. 58, Issue 1 https://doi.org/10.1016/0002-9343(75)90532-X	journal	January 1975
Towards ultrahigh sensitivity analysis of 41Ca Moore, I. D.; Bailey, K.; Lu, Z. -T. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 204 https://doi.org/10.1016/S0168-583X(03)00490-7	journal	May 2003
Human calcium metabolism including bone resorption measured with 41Ca tracer Freeman, Stewart P. H. T.; King, Janet C.; Vieira, Nancy E. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 123, Issue 1-4 https://doi.org/10.1016/S0168-583X(96)00701-X	journal	March 1997
Calcium resorption from bone in a human studied by 41Ca tracing Johnson, R. R.; Berkovits, D.; Boaretto, E. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 92, Issue 1-4 https://doi.org/10.1016/0168-583X(94)96059-3	journal	June 1994
Preparation of 41Ca AMS standards Nishiizumi, Kunihiko; Caffee, Marc W.; DePaolo, Donald J. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 172, Issue 1-4 https://doi.org/10.1016/S0168-583X(00)00150-6	journal	October 2000
Disturbance of Calcium Metabolism by Anticonvulsant Drugs Richens, A.; Rowe, D. J. F. BMJ, Vol. 4, Issue 5727 https://doi.org/10.1136/bmj.4.5727.73	journal	October 1970
Biological sample preparation and 41Ca AMS measurement at LLNL Freeman, S. P. H. T.; Serfass, R. E.; King, J. C. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 99, Issue 1-4 https://doi.org/10.1016/0168-583X(95)00342-8	journal	May 1995
Techniques: The application of accelerator mass spectrometry to pharmacology and toxicology White, Ian N. H.; Brown, Karen Trends in Pharmacological Sciences, Vol. 25, Issue 8 https://doi.org/10.1016/j.tips.2004.06.009	journal	August 2004

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