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Title: Synthetic analogs of bacterial quorum sensors

Patent ·
OSTI ID:1034327
 [1];  [1];  [1]
  1. Los Alamos, NM
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Bacterial quorum-sensing molecule analogs having the following structures: ##STR00001## and methods of reducing bacterial pathogenicity, comprising providing a biological system comprising pathogenic bacteria which produce natural quorum-sensing molecule; providing a synthetic bacterial quorum-sensing molecule having the above structures and introducing the synthetic quorum-sensing molecule into the biological system comprising pathogenic bacteria. Further is provided a method of targeted delivery of an antibiotic, comprising providing a synthetic quorum-sensing molecule; chemically linking the synthetic quorum-sensing molecule to an antibiotic to produce a quorum-sensing molecule-antibiotic conjugate; and introducing the conjugate into a biological system comprising pathogenic bacteria susceptible to the antibiotic.

Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC52-06NA25396
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Number(s):
8,071,790
Application Number:
12/551,994
OSTI ID:
1034327
Country of Publication:
United States
Language:
English

References (7)

Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound journal January 2002
Roles of Pseudomonas aeruginosa las andrhl Quorum-Sensing Systems in Control of Twitching Motility journal March 1999
The Synthesis of Optically Pure Enantiomers of N -Acyl-homoserine Lactone Autoinducers and Their Analogues journal April 2001
Inhibition of Quorum Sensing in Pseudomonas aeruginosa by N-Acyl Cyclopentylamides journal March 2007
The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N ‐butyryl‐homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase journal April 1997
Quorum-Sensing Genes in Pseudomonas aeruginosa Biofilms: Their Role and Expression Patterns journal April 2001
DNA sequences and characterization of four early genes of the tryptophan pathway in Pseudomonas aeruginosa. journal January 1990

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