FDA Approved Registration of Erythromycin for Treatment of Bacterial Kidney Disease (BKD) in Juvenile and Adult Chinook Salmon : Annual Report, Reporting Period March 10, 1989 to March 9, 1990.
Erythromycin is a therapeutic substance useful against bacterial kidney disease in salmon. In 1989 we began a multi year project to learn more about erythromycin applied to juvenile and adult salmon, with the goal of achieving registration of erythromycin with the US Food and Drug Administration. To begin the study, we studied the pharmacokinetics of erythromycin administered to both adult and juvenile chinook salmon. We monitored blood plasmas time curves from individual adult fish injected with two forms of injectable erythromycin using one of three routes of administration. In addition, we began experiments to evaluate hatchery applications of erythromycin to individually marked adult salmon, and we recovered blood tissues from these fish at the time of spawning. To determine how to use erythromycin in juvenile salmon, we evaluated the adsorption and elimination of erythromycin applied arterially and orally to individual juvenile fish. In feeding trials we determined the palatability to juvenile chinook salmon of feed made with one of two different carriers for erythromycin thiocyanate. 35 refs., 4 figs. , 3 tabs.
- Research Organization:
- University of Idaho. Department of Fish and Wildlife Resources
- Sponsoring Organization:
- US Bonneville Power Administration
- DOE Contract Number:
- FG79-89BP96247
- OSTI ID:
- 5392957
- Report Number(s):
- DOE/BP-96247-1; ON: DE91017166
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
13 HYDRO ENERGY
ANADROMOUS FISHES
BACTERIAL DISEASES
ERYTHROMYCIN
PHARMACOLOGY
UROGENITAL SYSTEM DISEASES
THERAPY
BONNEVILLE POWER ADMINISTRATION
COLUMBIA RIVER BASIN
EXPERIMENT PLANNING
FEASIBILITY STUDIES
FISHERIES
INGESTION
INJECTION
JUVENILES
PROGRESS REPORT
SALMON
TISSUE DISTRIBUTION
US FDA
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
AQUATIC ORGANISMS
DISEASES
DISTRIBUTION
DOCUMENT TYPES
DRUGS
FISHES
INFECTIOUS DISEASES
INTAKE
NATIONAL ORGANIZATIONS
PLANNING
US DOE
US HEW
US ORGANIZATIONS
VERTEBRATES
Bacterial kidney disease (Fish disease) - Treatment
550600* - Medicine
550100 - Behavioral Biology
130600 - Hydro Energy- Environmental Aspects