Comparison of technetium-99m pyrophosphate and technetium-99m DTPA aerosols for SPECT ventilation lung imaging

Journal Article · Tue Nov 01 00:00:00 EST 1988 · J. Nucl. Med.; (United States)

OSTI ID:6867727

Isitman, A T; Collier, B D; Palmer, D W; Trembath, L; Krasnow, A Z; Rao, S A; Hellman, R S; Hoffmann, R G; Peck, D C; Dellis, C J

Although (/sup 99m/Tc) diethylenetriaminepentaacetic acid (DTPA) is currently the most widely used radioaerosol, rapid alveolar clearance limits its usefulness for single photon emission computed tomography (SPECT) ventilation lung imaging. Previous research has shown that (/sup 99m/Tc)phosphate compounds have high alveolar deposition and slow clearance and thus provide suitable aerosols for pulmonary ventilation studies. We have compared the pulmonary retention and blood levels of (/sup 99m/Tc)pyrophosphate (PYP) and (99mTc)DTPA in eight normal nonsmoking male volunteers. These two radioaerosols have comparable pulmonary deposition. Technetium-99m PYP, however, has a much slower pulmonary clearance which allows sufficient time (20 or more minutes) for SPECT data acquisition using a single-headed rotating gamma camera. While the radiation absorbed dose to the lungs for (/sup 99m/Tc)PYP (0.31 rad/mCi) is greater than for (/sup 99m/Tc)DTPA (0.11 rad/mCi), it is at a clinically acceptable and safe level.

• Research Organization: Medical College of Wisconsin, Milwaukee (USA)
• OSTI ID: 6867727
• Journal Information: J. Nucl. Med.; (United States), Vol. 29:11
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
LUNGS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
RADIOPHARMACEUTICALS
COMPARATIVE EVALUATIONS
DTPA
ISOMERIC NUCLEI
LUNG CLEARANCE
ORGANOMETALLIC COMPOUNDS
PYROPHOSPHATES
RADIATION DOSES
TECHNETIUM 99
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOSES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
TECHNETIUM ISOTOPES
TOMOGRAPHY
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics