Chemical breakdown of technetium-99m DTPA during nebulization
Aerosols of /sup 99m/Tc diethylenetriaminepentaacetic acid ((/sup 99m/Tc)DTPA) used for measuring lung permeability and lung ventilation require a radioaerosol delivery system to produce an aerosol with reproducible size and radiochemical purity. To test how well nebulizers meet this requirement, radiochemical purity of aerosols produced with a jet and an ultrasonic nebulizer was evaluated. The activity median aerodynamic diameter (AMAD) and geometric standard deviation (sigma g) of radioaerosols were 0.46 micron (sigma g = 1.6) for the jet nebulizer and 0.70 micron (sigma g = 1.7) for the ultrasonic nebulizer. Paper and liquid chromatographic assays were obtained on the (/sup 99m/Tc)DTPA aerosol solute produced with each nebulizer. The results of these tests showed major differences in radiochemical purity. Aerosols produced in the jet nebulizer consistently showed greater than 90% of the radioactivity bound to the DTPA ligand whereas aerosols produced in the ultrasonic nebulizer showed less than 10% of the radioactivity bound to DTPA. The results support the need to test radiochemical purity of aerosols before using an aerosol nebulizer for pulmonary imaging and clearance studies.
- Research Organization:
- Univ. of Rochester, NY
- OSTI ID:
- 6862886
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 3
- Country of Publication:
- United States
- Language:
- English
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LUNGS
PERMEABILITY
TECHNETIUM 99
EVALUATION
RADIOCHEMISTRY
DOGS
DTPA
ISOMERIC NUCLEI
LIQUID COLUMN CHROMATOGRAPHY
LUNG CLEARANCE
PARTICLE SIZE
RADIOACTIVE AEROSOLS
AEROSOLS
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CHEMISTRY
CHROMATOGRAPHY
CLEARANCE
COLLOIDS
DISPERSIONS
DRUGS
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
SEPARATION PROCESSES
SIZE
SOLS
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics