Lung clearance of inhaled /sup 99m/Tc-DTPA in the dog
A study was made of the reproducibility of measuring an index of permeability of respiratory epithelium in dogs using aerosolized /sup 99m/Tc-DTPA (diethylenetriaminepentaacetate). The method uses a gamma camera to measure the rate of clearance of soluble radioactive aerosol deposited in the lung. A solution of /sup 99m/Tc-DTPA in normal saline was aerosolized by an ultrasonic nebulizer. Eleven anesthetized dogs breathing spontaneously inhaled the resulting droplets for 2 min. Mass median aerodynamic diameter of the droplets was 4.4 ..mu..m with a geometric standard deviation of 2.1. Clearance from the lung was monitored by quantitative gamma camera imaging for up to 2 h. For a 60-min observation period, the biological half-life for clearance of /sup 99m/Tc-DTPA from both lungs was 66 +/- 11 (SD) min. Apical regions cleared significantly slower than basal regions, probably because of a larger portion of bronchial tissue in the apical region of the dog's lung. The best reproducibility of absorption of /sup 99m/Tc-DTPA in the dog was obtained from basal regions and peripheral zones of the lung within 30 min after inhalation of the radioaerosol.
- Research Organization:
- Univ. of Rochester School of Medicine and Dentistry, NY
- DOE Contract Number:
- AC02-76EV03490
- OSTI ID:
- 5446268
- Journal Information:
- J. Appl. Physiol.: Respir., Environ. Exercise Physiol.; (United States), Vol. 57:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
DTPA
LUNG CLEARANCE
EPITHELIUM
PERMEABILITY
TECHNETIUM 99
BIOLOGICAL ACCUMULATION
BIOLOGICAL HALF-LIFE
BLOOD
COMPARATIVE EVALUATIONS
DOGS
EXPERIMENTAL DATA
GAMMA CAMERAS
IMAGES
INHALATION
ISOMERIC NUCLEI
LUNGS
RADIOACTIVE AEROSOLS
RETENTION
AEROSOLS
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CAMERAS
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
DATA
DISPERSIONS
DRUGS
EXCRETION
HOURS LIVING RADIOISOTOPES
INFORMATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
SOLS
TECHNETIUM ISOTOPES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics