Tumor imaging by antineuroblastoma monoclonal antibody and its application to treatment

Journal Article · Sat Oct 01 00:00:00 EDT 1988 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19881001)62:7<1282::AID-CNCR2820620706>3.0.CO;2-N· OSTI ID:6735593

Etoh, T; Takahashi, H; Maie, M; Ohnuma, N; Tanabe, M

Antineuroblastoma monoclonal antibody (MoAb) was labeled with iodine-131 (/sup 131/I) and injected into transplantable human neuroblastoma-bearing nude mice in vivo. Imaging of the tumor by gamma camera was then attempted. At the fourth day after injection of the antibody, relatively heavy labeling was observed in the tumor. Principal organs were removed and their /sup 131/I uptake was determined. A high radioactivity count was detected in the tumor, indicating efficacy of this antibody in tumor imaging of neuroblastoma. This antibody was labeled with /sup 131/I and injected into transplantable human neuroblastoma-bearing mice. Apparent inhibition of tumor growth was observed in animals treated as such compared with animals of the control group, MoAb alone group, and /sup 131/I alone group (P less than 0.05). In addition, pathohistologic study showed binding of /sup 131/I to tumor cells and necrotic changes, suggesting the possibility of application of this MoAb to the treatment of neuroblastoma.

• Research Organization: Chiba Univ. (Japan)
• OSTI ID: 6735593
• Journal Information: Cancer (Philadelphia); (United States), Vol. 62:7
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
IODINE 131
UPTAKE
MONOCLONAL ANTIBODIES
LABELLING
AUTORADIOGRAPHY
DIAGNOSIS
DIAGNOSTIC USES
EXPERIMENTAL NEOPLASMS
MICE
RADIOTHERAPY
THERAPEUTIC USES
TISSUE DISTRIBUTION
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPES
RADIOLOGY
RODENTS
THERAPY
USES
VERTEBRATES
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