B cell infiltration of the thymic medulla in New Zealand black, New Zealand white, and (New Zealand black x New Zealand white)F1 mice. Effect of total lymphoid irradiation

Journal Article · Tue May 01 00:00:00 EDT 1990 · Arthritis and Rheumatism; (USA)

DOI:https://doi.org/10.1002/art.1780330513· OSTI ID:6714791

Farinas, M C; Adkins, B; Stall, A M; Weissman, I; Strober, S ^[1]

---

1. Stanford Univ. School of Medicine, CA (USA)

Thymuses from female (New Zealand black x New Zealand white)F1 (( NZB x NZW)F1), New Zealand black, and New Zealand white mice of different ages were examined by immunohistochemical and flow cytometric analysis. Two-and-a-half-month-old (NZB x NZW)F1 mice showed infiltration of the thymus with B cells, and by 6-8 months of age, showed a disruption of the entire medullary area. More than 80% of the thymic B cells had the phenotypic characteristics of conventional B cells (IgM+, IgD+, Ly-1-). Total lymphoid irradiation induced a marked depletion of medullary B cells and a restoration of the thymic architecture.

• OSTI ID: 6714791
• Journal Information: Arthritis and Rheumatism; (USA), Vol. 33:5; ISSN 0004-3591
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LYMPHATIC SYSTEM
IRRADIATION
THYMUS
BIOLOGICAL RADIATION EFFECTS
AGE DEPENDENCE
CELL FLOW SYSTEMS
LYMPHOCYTES
MICE
PHENOTYPE
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
LEUKOCYTES
MAMMALS
MATERIALS
ORGANS
RADIATION EFFECTS
RODENTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals