Thyroid cancer. Reevaluation of an experimental model for radiogenic endocrine carcinogenesis
The status of experimental studies of radiogenic thyroid cancer is appraised, and some older data are reinterpreted in the light of more recent findings. Problems of thyroid dosimetry, particularly the dosimetry of internal radioiodides, are discussed. The steps in radiation carcinogenesis during the acute phase, the latent phase, and the phase of tumor growth are discussed in terms of thyroid epithelial cell population changes. The roles of three cell populations (undamaged or completely repaired epithelial cells, oncogenically initiated cells, and terminally damaged but functionally competent cells) in neoplasia are described. Finally, the implications for man of these experimental results and conclusions are discussed. 89 refs., 4 figs.
- Research Organization:
- Radiation Effects Research Foundation, Hiroshima (Japan)
- DOE Contract Number:
- AC01-76EV03161
- OSTI ID:
- 6386453
- Report Number(s):
- RERF-TR-5-83; ON: DE86007108
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
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SURVIVAL CURVES
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BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
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560151* - Radiation Effects on Animals- Man
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