Radiogenic neoplasia in thyroid and mammary clonogens

Technical Report · Wed May 20 00:00:00 EDT 1992

DOI:https://doi.org/10.2172/7279046· OSTI ID:7279046

Clifton, K H

We have developed rat thyroid and mammary clonogen transplantation systems for the study of radiogenic cancer induction at the target cell level in vivo. The epithelial cell populations of both glands contain small subpopulations of cells which are capable of giving rise to monoclonal glandular structures when transplanted and stimulated with appropriate hormones. Previous results indicated that these clonogens are the precursor cells of radiogenic cancer, and that initiation, is common event at the clonegenic cell level. Detailed information on the physiologic control of clonogen proliferation, differentiation, and total numbers is thus essential to an understanding of the carcinogenic process. We report here studies on investigations on the relationships between grafted thyroid cell number and the rapidity and degree of reestablishment of the thyroid-hypothalamus-pituitary feedback axis in thyroidectomized rats maintained on a normal diet or an iodine deficient diet; studies of the persistence of, and the differentiation potential and functional characteristics of, the TSH-(thyrotropin-) responsive sub- population of clonogens during goitrogenesis, the plateau-phase of goiter growth, and goiter involution; studies of changes in the size of the clonogen sub-population during goitrogenesis, goiter involution and the response to goitrogen rechallenge; and a large carcinogenesis experiment on the nature of the grafted thyroid cell number-dependent suppression of promotion/progression to neoplasia in grafts of radiation-initiated thyroid cells. Data from these studies will be used in the design of future carcinogenesis experiments on neoplastic initiation by high and low LET radiations and on cell interactions during the neoplastic process.

• Research Organization: Wisconsin Univ., Madison, WI (United States). Dept. of Human Oncology
• Sponsoring Organization: USDOE; USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-87ER60507
• OSTI ID: 7279046
• Report Number(s): DOE/ER/60507-6; ON: DE92016312
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CLONE CELLS
ONCOGENIC TRANSFORMATIONS
EXPERIMENTAL NEOPLASMS
RADIOINDUCTION
IN VIVO
MAMMARY GLANDS
PROGRESS REPORT
RATS
THYROID
ANIMALS
BODY
CELL CULTURES
CELL TRANSFORMATIONS
DOCUMENT TYPES
ENDOCRINE GLANDS
GLANDS
MAMMALS
ORGANS
RODENTS
VERTEBRATES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture