Studies of the toxic interaction of disinfection by-products
A large number and variety of compounds are formed in the process of chlorinating drinking water. Many of the compounds have been shown to be toxic and are currently being further evaluated by the US Environmental Protection Agency (EPA). One group of the halopropanones found in chlorinated drinking water is the dichloropropanones. The toxicological properties of this group have not been well characterized. In addition, a number of investigators have shown that ketones potentiate the hepatotoxicity of haloalkanes. The authors conducted a series of studies to explore both the toxicity of the dichloropropanones and their potential interaction with a well-characterized haloalkane, carbon tetrachloride. A variety of toxicological and biochemical endpoints were used to evaluate the toxicity of the dichloropropanones and their interaction with CCl/sub 4/, including cytochrome P-450 concentration, reduced glutathione levels, pentane generation, serum enzyme activities, and histopathology. Administration of 1,1-dichloropropanone (DCP) resulted in elevated serum enzymes associated with periportal necrosis. Glutathione levels were reduced by the administration of 1,1-DCP; pentane generation was not increased. When 1,1-DCP was given prior to CCl/sub 4/, the data were consistent with additivity. Administration of 1,3-DCP did not result in elevated serum enzymes, nor was there histopathologic evidence of necrosis. Glutathione levels and pentane generation in the 1,3-DCP-treated groups were the same as those of controls. Inhibition of the toxicologic effects of CCl/sub 4/ in a dose-related manner was observed when 1,3-DCP was administered prior to CCl/sub 4/.
- Research Organization:
- Environmental Protection Agency, Cincinnati, OH
- OSTI ID:
- 5663743
- Journal Information:
- Environ. Health Perspect.; (United States), Vol. 69
- Country of Publication:
- United States
- Language:
- English
Similar Records
Oral toxicity of 1,2-dichloropropane: Acute, short-term, and long-term studies in rats
Effects of separate and combined chronic mercuric chloride and sodium selenate administration in rats: histological, ultrastructural, and x-ray microanalytical studies of liver and kidney
Related Subjects
AMINOTRANSFERASES
BLOOD CHEMISTRY
CARBON TETRACHLORIDE
BIOLOGICAL EFFECTS
SYNERGISM
KETONES
LACTATE DEHYDROGENASE
LIVER
PATHOLOGICAL CHANGES
BY-PRODUCTS
CHLORINATED ALIPHATIC HYDROCARBONS
CHLORINATION
CYTOCHROMES
DISINFECTANTS
DRINKING WATER
ENZYME ACTIVITY
GLUTATHIONE
MICE
WATER TREATMENT
ANIMALS
BODY
CHEMICAL REACTIONS
DIGESTIVE SYSTEM
DRUGS
ENZYMES
GERMICIDES
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
HALOGENATION
HEMIACETAL DEHYDROGENASES
HYDROGEN COMPOUNDS
MAMMALS
NITROGEN TRANSFERASES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PEPTIDES
PIGMENTS
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RODENTS
TRANSFERASES
VERTEBRATES
WATER
560300* - Chemicals Metabolism & Toxicology