Oral toxicity of 1,2-dichloropropane: Acute, short-term, and long-term studies in rats
The investigation characterized the acute and short- and long-term toxic potency of orally administered 1,2-dichloropropane (DCP). In the acute and short-term studies, male rats of 250-300 g were gavaged with 0, 100, 250, 500, or 1000 mg DCP/kg in corn oil once daily for up to 10 consecutive days. Although ingestion of DCP caused body weight loss and CNS depression, few other toxic effects were manifest 24 hr after a single dose of the chemical. Morphological changes were limited to liver centrilobular cells in 500 and 1000 mg/kg rats. Similarly, elevated activity of some serum enzymes occurred only at these two highest dose levels. Hepatic nonprotein sulfhydryl (NPS) levels were decreased and renal NPS levels increased at 24 hr. In the short-term study resistance developed to DCP hepatotoxicity over the 10 consecutive days of exposure, as reflected by progressively lower serum enzyme levels and by decreases in the severity and incidence of toxic hepatitis and periportal vacuolization. Nucleolar enlargement in hepatocytes, however, was observed at all dosage levels at 5 and 10 days. There were a number of manifestations of hemolytic anemia, including erythrophagocytosis in the liver, splenic hemosiderosis and hyperplasia of erythropoietic elements of the red pulp, renal tubular cell hemosiderosis, and hyperbilirubinemia.
- Research Organization:
- Georgia Univ., Athens, GA (USA). Dept. of Pharmacology and Toxicology
- OSTI ID:
- 6983047
- Report Number(s):
- PB-90-140831/XAB
- Resource Relation:
- Other Information: Pub. in Fundamental and Applied Toxicology, Vol. 12, No. 4, 713-730(1989)
- Country of Publication:
- United States
- Language:
- English
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CHLORINATED AROMATIC HYDROCARBONS
TOXICITY
LIVER
MORPHOLOGICAL CHANGES
ANEMIAS
BLOOD CHEMISTRY
BLOOD SERUM
DOSE-RESPONSE RELATIONSHIPS
ENZYMES
KIDNEYS
MICROSOMES
ORAL ADMINISTRATION
RATS
REPRODUCTION
SPLEEN
SURVIVAL TIME
ANIMALS
AROMATICS
BODY
CELL CONSTITUENTS
DIGESTIVE SYSTEM
DISEASES
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HEMIC DISEASES
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANOIDS
ORGANS
RIBOSOMES
RODENTS
SYMPTOMS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology