Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3
- Institute of Molecular Biology and Biotechnology, Crete (Greece)
- National Institute for Medical Research, London (United Kingdom); and others
We have isolated and characterized cDNA clones encoding a novel human homeobox gene, MOX2, the homologue of the murine mox-2 gene. The MOX2 protein contains all of the characteristic features of Mox-2 proteins of other vertebrate species, namely the homeobox, the polyhistidine stretch, and a number of potential serine/threonine phosphorylation sites. The homeodomain of MOX2 protein is identical to all other vertebrate species reported so far (rodents and amphibians). Outside the homeodomain, Mox-2 proteins share a high degree of identity, except for a few amino acid differences encountered between the human and the rodent polypeptides. A polyhistidine stretch of 12 amino acids in the N terminal region of the protein is also conserved among humans, rodents, and (only partly) amphibians. The chromosomal position of MOX2 was assigned to 7p22.1-p21.3. 31 refs., 3 figs.
- OSTI ID:
- 209938
- Journal Information:
- Genomics, Vol. 26, Issue 3; Other Information: PBD: 10 Apr 1995
- Country of Publication:
- United States
- Language:
- English
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