Radionuclide cerebral perfusion imaging: Normal pattern
- Mt. Sinai Medical Center, New York, NY (United States)
Regional cerebral perfusion imaging using a new class of {sup 99m}Tc and {sup 123}I labeled compounds which traverse the blood brain barrier and SPECT imaging technology provides an opportunity to assess this physiologic phenomenon during normal cerebral function and as a manifestation of disease in the central nervous system disease. These applications pose a challenge to the nuclear medicine physician for several reasons: (a) the complex and somewhat unfamiliar functional anatomy, (b) the marked regional differences in regional cerebral perfusion at rest, (c) the lack of understanding of the effect of variations in ambient conditions on regional cerebral perfusion. The difficulties in interpretation are augmented by the display itself. There is frequently no difficulty in differentiating between gray and white matter. However, the frequently used {open_quotes}hot body{close_quotes} color maps, introduce a good deal of contrast, producing displays with apparent interruption in regional cortical perfusion whereas black and white displays provide minimal contrast in the regional cortical activity. The authors sought to define how much variation in regional cerebral perfusion is {open_quotes}allowed{close_quotes} under controlled conditions, to establish a basis to interpret if changes in the environment, psychological interventions, or disease states are accompanied by a measurable change. 2 figs., 1 tab.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- OSTI ID:
- 139691
- Report Number(s):
- CONF-9110368-; ON: TI92014827; TRN: 93:003237-009
- Resource Relation:
- Conference: Brain SPECT perfusion imaging: image acquisition, processing, display, and interpretation, Brookhaven, NY (United States), 8-9 Oct 1991; Other Information: PBD: [1991]; Related Information: Is Part Of Brain SPECT perfusion imaging: Image acquisition, processing, display, and interpretation; Weber, D.A.; Woodhead, A.D.; Vivirito, K.J. [eds.] [Brookhaven National Lab., Upton, NY (United States)]; Devous, M.D. Sr. [ed.] [Texas Univ., Dallas, TX (United States). Southwestern Medical Center]; Tikofsky, R.S. [ed.] [Medical Coll. of Wisconsin, Milwaukee, WI (United States)]; PB: 132 p.
- Country of Publication:
- United States
- Language:
- English
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