Technetium-99m HM-PAO-SPECT study of regional cerebral perfusion in early Alzheimer's disease
Regional cerebral perfusion was evaluated by single photon emission computed tomography (SPECT) using technetium-99m hexamethylpropyleneamine oxime ((/sup 99m/Tc)HM-PAO) in sixteen patients with Alzheimer's disease (AD) in early clinical phase and in 16 healthy elderly controls. In all patients transmission computed tomography (TCT) and/or magnetic resonance imaging (MRI) did not show focal brain abnormalities. Relative to normal subjects, AD patients showed significant reductions in cortical/cerebellar activity ratio: cortical perfusion was globally depressed with the largest reductions in frontal and posterior temporo-parietal cortices. Asymmetries of relative perfusion between cerebral hemispheres were also demonstrated when language was affected or visuospatial functions were unevenly impaired. In patients with early AD, SPECT provides functional information to be compared with clinical and psychometric data.
- Research Organization:
- Univ. of Milan (Italy)
- OSTI ID:
- 6746062
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 29:9
- Country of Publication:
- United States
- Language:
- English
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ISOMERIC NUCLEI
NMR IMAGING
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ORGANOMETALLIC COMPOUNDS
OXIMES
PATIENTS
PERFUSED ORGANS
TECHNETIUM 99
AMINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
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INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
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MAGNETIC RESONANCE
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
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ORGANIC NITROGEN COMPOUNDS
ORGANS
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550601* - Medicine- Unsealed Radionuclides in Diagnostics
550600 - Medicine