Extracytoplasmic function σ factors of the widely distributed group ECF41 contain a fused regulatory domain: ECF41 Sigma Factors
Abstract
Bacteria need signal transducing systems to respond to environmental changes. Next to one- and two-component systems, alternative σ factors of the extracytoplasmic function (ECF) protein family represent the third fundamental mechanism of bacterial signal transduction. A comprehensive classification of these proteins identified more than 40 phylogenetically distinct groups, most of which are not experimentally investigated. Here, we present the characterization of such a group with unique features, termed ECF41. Among analyzed bacterial genomes, ECF41 σ factors are widely distributed with about 400 proteins from 10 different phyla. They lack obvious anti-σ factors that typically control activity of other ECF σ factors, but their structural genes are often predicted to be cotranscribed with carboxymuconolactone decarboxylases, oxidoreductases, or epimerases based on genomic context conservation. We demonstrate for Bacillus licheniformis and Rhodobacter sphaeroides that the corresponding genes are preceded by a highly conserved promoter motif and are the only detectable targets of ECF41-dependent gene regulation. In contrast to other ECF σ factors, proteins of group ECF41 contain a large C-terminal extension, which is crucial for σ factor activity. Our data demonstrate that ECF41 σ factors are regulated by a novel mechanism based on the presence of a fused regulatory domain.
- Authors:
-
- Ludwig-Maximilians-Univ., Munich (Germany). Dept. of Biology
- Univ. of Wisconsin, Madison, WI (United States). Dept. of Bacteriology
- Publication Date:
- Research Org.:
- Univ. of Wisconsin, Madison, WI (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1623572
- Grant/Contract Number:
- FG02-05ER15653
- Resource Type:
- Accepted Manuscript
- Journal Name:
- MicrobiologyOpen
- Additional Journal Information:
- Journal Volume: 1; Journal Issue: 2; Journal ID: ISSN 2045-8827
- Publisher:
- Wiley
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Microbiology
Citation Formats
Wecke, Tina, Halang, Petra, Staroń, Anna, Dufour, Yann S., Donohue, Timothy J., and Mascher, Thorsten. Extracytoplasmic function σ factors of the widely distributed group ECF41 contain a fused regulatory domain: ECF41 Sigma Factors. United States: N. p., 2012.
Web. doi:10.1002/mbo3.22.
Wecke, Tina, Halang, Petra, Staroń, Anna, Dufour, Yann S., Donohue, Timothy J., & Mascher, Thorsten. Extracytoplasmic function σ factors of the widely distributed group ECF41 contain a fused regulatory domain: ECF41 Sigma Factors. United States. https://doi.org/10.1002/mbo3.22
Wecke, Tina, Halang, Petra, Staroń, Anna, Dufour, Yann S., Donohue, Timothy J., and Mascher, Thorsten. Fri .
"Extracytoplasmic function σ factors of the widely distributed group ECF41 contain a fused regulatory domain: ECF41 Sigma Factors". United States. https://doi.org/10.1002/mbo3.22. https://www.osti.gov/servlets/purl/1623572.
@article{osti_1623572,
title = {Extracytoplasmic function σ factors of the widely distributed group ECF41 contain a fused regulatory domain: ECF41 Sigma Factors},
author = {Wecke, Tina and Halang, Petra and Staroń, Anna and Dufour, Yann S. and Donohue, Timothy J. and Mascher, Thorsten},
abstractNote = {Bacteria need signal transducing systems to respond to environmental changes. Next to one- and two-component systems, alternative σ factors of the extracytoplasmic function (ECF) protein family represent the third fundamental mechanism of bacterial signal transduction. A comprehensive classification of these proteins identified more than 40 phylogenetically distinct groups, most of which are not experimentally investigated. Here, we present the characterization of such a group with unique features, termed ECF41. Among analyzed bacterial genomes, ECF41 σ factors are widely distributed with about 400 proteins from 10 different phyla. They lack obvious anti-σ factors that typically control activity of other ECF σ factors, but their structural genes are often predicted to be cotranscribed with carboxymuconolactone decarboxylases, oxidoreductases, or epimerases based on genomic context conservation. We demonstrate for Bacillus licheniformis and Rhodobacter sphaeroides that the corresponding genes are preceded by a highly conserved promoter motif and are the only detectable targets of ECF41-dependent gene regulation. In contrast to other ECF σ factors, proteins of group ECF41 contain a large C-terminal extension, which is crucial for σ factor activity. Our data demonstrate that ECF41 σ factors are regulated by a novel mechanism based on the presence of a fused regulatory domain.},
doi = {10.1002/mbo3.22},
journal = {MicrobiologyOpen},
number = 2,
volume = 1,
place = {United States},
year = {Fri May 25 00:00:00 EDT 2012},
month = {Fri May 25 00:00:00 EDT 2012}
}
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