Quantitative encapsulation and retention of 227Th and decay daughters in core–shell lanthanum phosphate nanoparticles

Toro-González, Miguel; Dame, Ashley N.; Foster, Carmen M.; Millet, Larry J.; Woodward, Jonathan D.; Rojas, Jessica V.; Mirzadeh, Saed; Davern, Sandra M.

doi:10.1039/D0NR01172J

Title: Quantitative encapsulation and retention of ²²⁷Th and decay daughters in core–shell lanthanum phosphate nanoparticles

Abstract

Targeted alpha therapy (TAT) offers great promise for treating recalcitrant tumors and micrometastatic cancers. One drawback of TAT is the potential damage to normal tissues and organs due to the relocation of decay daughters from the treatment site. As such, the present study evaluates La(²²⁷Th)PO₄ core (C) and core +2 shells (C2S) nanoparticles (NPs) as a delivery platform of ²²⁷Th to minimize systemic distribution of decay daughters, ²²³Ra and ²¹¹Pb. In vitro retention of decay daughters within La(²²⁷Th)PO₄ C NPs was influenced by the concentration of reagents used during synthesis, in which the leakage of ²²³Ra was between 0.4 ± 0.2% and 20.3 ± 1.1% in deionized water. Deposition of two nonradioactive LaPO₄ shells onto La(²²⁷Th)PO₄ C NPs increased the retention of decay daughters to >99.75%. The toxicity of the nonradioactive LaPO₄ C and C2S NP delivery platforms was examined in a mammalian breast cancer cell line, BT-474. No significant decrease in cell viability was observed for a monolayer of BT-474 cells for NP concentrations below 233.9 μg mL^–1, however cell viability decreased below 60% when BT-474 spheroids were incubated with either LaPO₄ C or C2S NPs at concentrations exceeding 29.2 μg mL^–1. La(²²⁷Th)PO₄ C2S NPs exhibit a high encapsulationmore »« less

Authors:

^[1];

^[2];

^[3]; Woodward, Jonathan D. ^[2];

^[4];

^[2];

^[2]

Virginia Commonwealth Univ., Richmond, VA (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)
Virginia Commonwealth Univ., Richmond, VA (United States)

Publication Date:: Mon Apr 20 00:00:00 EDT 2020

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Nuclear Physics (NP); USDOE Laboratory Directed Research and Development (LDRD) Program

OSTI Identifier:: 1617795

Alternate Identifier(s):: OSTI ID: 1615862

Grant/Contract Number:: AC05-00OR22725

Resource Type:: Accepted Manuscript

Journal Name:: Nanoscale

Additional Journal Information:: Journal Volume: 12; Journal Issue: 17; Journal ID: ISSN 2040-3364

Publisher:: Royal Society of Chemistry

Country of Publication:: United States

Language:: English

Subject:: 07 ISOTOPE AND RADIATION SOURCES

Citation Formats


                    Toro-González, Miguel, Dame, Ashley N., Foster, Carmen M., Millet, Larry J., Woodward, Jonathan D., Rojas, Jessica V., Mirzadeh, Saed, and Davern, Sandra M. Quantitative encapsulation and retention of 227Th and decay daughters in core–shell lanthanum phosphate nanoparticles.  United States: N. p., 2020. 
Web.  doi:10.1039/D0NR01172J.

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                    Toro-González, Miguel, Dame, Ashley N., Foster, Carmen M., Millet, Larry J., Woodward, Jonathan D., Rojas, Jessica V., Mirzadeh, Saed, & Davern, Sandra M. Quantitative encapsulation and retention of 227Th and decay daughters in core–shell lanthanum phosphate nanoparticles.  United States.  https://doi.org/10.1039/D0NR01172J

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                    Toro-González, Miguel, Dame, Ashley N., Foster, Carmen M., Millet, Larry J., Woodward, Jonathan D., Rojas, Jessica V., Mirzadeh, Saed, and Davern, Sandra M. Mon .  
"Quantitative encapsulation and retention of 227Th and decay daughters in core–shell lanthanum phosphate nanoparticles".  United States.  https://doi.org/10.1039/D0NR01172J.  https://www.osti.gov/servlets/purl/1617795.

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@article{osti_1617795,

  title        = {Quantitative encapsulation and retention of 227Th and decay daughters in core–shell lanthanum phosphate nanoparticles},

  author       = {Toro-González, Miguel and Dame, Ashley N. and Foster, Carmen M. and Millet, Larry J. and Woodward, Jonathan D. and Rojas, Jessica V. and Mirzadeh, Saed and Davern, Sandra M.},

  abstractNote = {Targeted alpha therapy (TAT) offers great promise for treating recalcitrant tumors and micrometastatic cancers. One drawback of TAT is the potential damage to normal tissues and organs due to the relocation of decay daughters from the treatment site. As such, the present study evaluates La(227Th)PO4 core (C) and core +2 shells (C2S) nanoparticles (NPs) as a delivery platform of 227Th to minimize systemic distribution of decay daughters, 223Ra and 211Pb. In vitro retention of decay daughters within La(227Th)PO4 C NPs was influenced by the concentration of reagents used during synthesis, in which the leakage of 223Ra was between 0.4 ± 0.2% and 20.3 ± 1.1% in deionized water. Deposition of two nonradioactive LaPO4 shells onto La(227Th)PO4 C NPs increased the retention of decay daughters to >99.75%. The toxicity of the nonradioactive LaPO4 C and C2S NP delivery platforms was examined in a mammalian breast cancer cell line, BT-474. No significant decrease in cell viability was observed for a monolayer of BT-474 cells for NP concentrations below 233.9 μg mL–1, however cell viability decreased below 60% when BT-474 spheroids were incubated with either LaPO4 C or C2S NPs at concentrations exceeding 29.2 μg mL–1. La(227Th)PO4 C2S NPs exhibit a high encapsulation and in vitro retention of radionuclides with limited contribution to cellular cytotoxicity for TAT applications.},

  doi          = {10.1039/D0NR01172J},

  journal      = {Nanoscale},

  number       = 17,

  volume       = 12,

  place        = {United States},

  year         = {Mon Apr 20 00:00:00 EDT 2020},

  month        = {Mon Apr 20 00:00:00 EDT 2020}

}

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Works referenced in this record:

Probing the effect of radiation damage on the structure of rare-earth phosphates
journal, December 2015

Rafiuddin, Mohamed Ruwaid; Grosvenor, Andrew P.
Journal of Alloys and Compounds, Vol. 653
DOI: 10.1016/j.jallcom.2015.08.276

In Vitro and In Vivo Efficacy of a Novel CD33-Targeted Thorium-227 Conjugate for the Treatment of Acute Myeloid Leukemia
journal, August 2016

Hagemann, U. B.; Wickstroem, K.; Wang, E.
Molecular Cancer Therapeutics, Vol. 15, Issue 10
DOI: 10.1158/1535-7163.MCT-16-0251

Targeted Alpha-Particle Therapy with 227Th-Labeled Antibodies
journal, September 2008

Dahle, Jostein; Larsen, Roy
Current Radiopharmaceuticalse, Vol. 1, Issue 3
DOI: 10.2174/1874471010801030209

Study of 223Ra uptake mechanism by Fe3O4 nanoparticles: towards new prospective theranostic SPIONs
journal, October 2016

Mokhodoeva, Olga; Vlk, Martin; Málková, Eva
Journal of Nanoparticle Research, Vol. 18, Issue 10
DOI: 10.1007/s11051-016-3615-7

Colloidal Synthesis of Luminescent Rhabdophane LaPO ₄ :Ln ³⁺ · x H ₂ O (Ln = Ce, Tb, Eu; x ≈ 0.7) Nanocrystals
journal, September 2004

Buissette, Valérie; Moreau, Mélanie; Gacoin, Thierry
Chemistry of Materials, Vol. 16, Issue 19
DOI: 10.1021/cm049323a

The in vivo fate of 225Ac daughter nuclides using polymersomes as a model carrier
journal, August 2019

Kruijff, R. M. de; Raavé, R.; Kip, A.
Scientific Reports, Vol. 9, Issue 1
DOI: 10.1038/s41598-019-48298-8

The Chemical Fate of 212Bi-DOTA Formed by β- Decay of 212Pb(DOTA)2-***
journal, January 1993

Mirzadeh, Saed; Kumar, Krishan; Gansow, Otto A.
Radiochimica Acta, Vol. 60, Issue 1
DOI: 10.1524/ract.1993.60.1.1

Ra-224 labeling of calcium carbonate microparticles for internal α-therapy: Preparation, stability, and biodistribution in mice
journal, March 2018

Westrøm, Sara; Malenge, Marion; Jorstad, Ida Sofie
Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 61, Issue 6
DOI: 10.1002/jlcr.3610

Atomistic modeling and experimental studies of radiation damage in monazite-type LaPO 4 ceramics
journal, February 2017

Ji, Yaqi; Kowalski, Piotr M.; Neumeier, Stefan
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 393
DOI: 10.1016/j.nimb.2016.09.031

Enhanced Loading Efficiency and Retention of ²²⁵ Ac in Rigid Liposomes for Potential Targeted Therapy of Micrometastases
journal, June 2008

Chang, Min-Yuan; Seideman, Jonathan; Sofou, Stavroula
Bioconjugate Chemistry, Vol. 19, Issue 6
DOI: 10.1021/bc700440a

Radiation damage in zircon and monazite
journal, July 1998

Meldrum, A.; Boatner, L. A.; Weber, W. J.
Geochimica et Cosmochimica Acta, Vol. 62, Issue 14
DOI: 10.1016/S0016-7037(98)00174-4

Synthesis and targeting of gold-coated ¹⁷⁷ Lu-containing lanthanide phosphate nanoparticles—A potential theranostic agent for pulmonary metastatic disease
journal, March 2018

Sobol, Nicholas; Sutherlin, Logan; Cedrowska, Edyta
APL Bioengineering, Vol. 2, Issue 1
DOI: 10.1063/1.5018165

Preparation of TH ²²⁷ -Labeled Radioimmunoconjugates, Assessment of Serum Stability and Antigen Binding Ability
journal, June 2007

Larsen, Roy H.; Borrebaek, Jorgen; Dahle, Jostein
Cancer Biotherapy and Radiopharmaceuticals, Vol. 22, Issue 3
DOI: 10.1089/cbr.2006.321

Improved 225 Ac daughter retention in InPO 4 containing polymersomes
journal, October 2017

de Kruijff, R. M.; Drost, K.; Thijssen, L.
Applied Radiation and Isotopes, Vol. 128
DOI: 10.1016/j.apradiso.2017.07.030

A Proof-of-Concept Study on the Therapeutic Potential of Au Nanoparticles Radiolabeled with the Alpha-Emitter Actinium-225
journal, February 2020

Salvanou, Evangelia-Alexandra; Stellas, Dimitris; Tsoukalas, Charalampos
Pharmaceutics, Vol. 12, Issue 2
DOI: 10.3390/pharmaceutics12020188

Simulation of ceramic materials relevant for nuclear waste management: Case of La 1−x Eu x PO 4 solid solution
journal, February 2017

Kowalski, Piotr M.; Ji, Yaqi; Li, Yan
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 393
DOI: 10.1016/j.nimb.2016.09.029

Microscopic effects of self-radiation damage in ²⁴⁴ Cm-doped LuPO ₄ crystals
journal, February 2001

Luo, J. S.; Liu, G. K.
Journal of Materials Research, Vol. 16, Issue 2
DOI: 10.1557/JMR.2001.0056

LaPO ₄ Nanoparticles Doped with Actinium-225 that Partially Sequester Daughter Radionuclides
journal, April 2011

Woodward, Jonathan; Kennel, Stephen J.; Stuckey, Alan
Bioconjugate Chemistry, Vol. 22, Issue 4
DOI: 10.1021/bc100574f

Multifunctional GdVO ₄ :Eu core–shell nanoparticles containing ²²⁵ Ac for targeted alpha therapy and molecular imaging
journal, January 2018

Toro-González, M.; Copping, R.; Mirzadeh, S.
Journal of Materials Chemistry B, Vol. 6, Issue 47
DOI: 10.1039/C8TB02173B

Targeted Alpha Therapy, an Emerging Class of Cancer Agents: A Review
journal, December 2018

Parker, Christopher; Lewington, Valerie; Shore, Neal
JAMA Oncology, Vol. 4, Issue 12
DOI: 10.1001/jamaoncol.2018.4044

An efficient chelator for complexation of thorium-227
journal, September 2016

Ramdahl, Thomas; Bonge-Hansen, Hanne T.; Ryan, Olav B.
Bioorganic & Medicinal Chemistry Letters, Vol. 26, Issue 17
DOI: 10.1016/j.bmcl.2016.07.034

Momentum Transfer to an Atom in a Molecule: Internal Excitation and Bond Dissociation
journal, February 1962

Hsiung, Chi‐hua; Gordus, Adon A.
The Journal of Chemical Physics, Vol. 36, Issue 4
DOI: 10.1063/1.1732693

Functionalized NaA nanozeolites labeled with 224,225Ra for targeted alpha therapy
journal, October 2013

Piotrowska, Agata; Leszczuk, Edyta; Bruchertseifer, Frank
Journal of Nanoparticle Research, Vol. 15, Issue 11
DOI: 10.1007/s11051-013-2082-7

Targeted alpha therapy using a novel CD70 targeted thorium-227 conjugate in <i>in vitro</i> and <i>in vivo</i> models of renal cell carcinoma
journal, April 2017

Hagemann, Urs B.; Mihaylova, Dessislava; Uran, Steinar R.
Oncotarget, Vol. 8, Issue 34
DOI: 10.18632/oncotarget.16910

Hydroxyapatite particles as carriers for 223Ra
journal, August 2016

Vasiliev, A. N.; Severin, A.; Lapshina, E.
Journal of Radioanalytical and Nuclear Chemistry, Vol. 311, Issue 2
DOI: 10.1007/s10967-016-5007-y

Prospective carriers of 223Ra for targeted alpha particle therapy
journal, September 2014

Kozempel, J.; Vlk, M.; Málková, E.
Journal of Radioanalytical and Nuclear Chemistry, Vol. 304, Issue 1
DOI: 10.1007/s10967-014-3615-y

Luminescent Core/Shell Nanoparticles with a Rhabdophane LnPO4-xH2O Structure: Stabilization of Ce3+-Doped Compositions
journal, February 2006

Buissette, V.; Moreau, M.; Gacoin, T.
Advanced Functional Materials, Vol. 16, Issue 3
DOI: 10.1002/adfm.200500285

Trastuzumab Conjugated Superparamagnetic Iron Oxide Nanoparticles Labeled with 225Ac as a Perspective Tool for Combined α-Radioimmunotherapy and Magnetic Hyperthermia of HER2-Positive Breast Cancer
journal, February 2020

Cędrowska, Edyta; Pruszyński, Marek; Gawęda, Weronika
Molecules, Vol. 25, Issue 5
DOI: 10.3390/molecules25051025

Enhanced Retention of the α-Particle-Emitting Daughters of Actinium-225 by Liposome Carriers
journal, November 2007

Sofou, Stavroula; Kappel, Barry J.; Jaggi, Jaspreet S.
Bioconjugate Chemistry, Vol. 18, Issue 6
DOI: 10.1021/bc070075t

Radiation resistance of the xenotime YPO4 from the computer simulation data
journal, February 2012

Urusov, V. S.; Grechanovsky, A. E.; Eremin, N. N.
Glass Physics and Chemistry, Vol. 38, Issue 1
DOI: 10.1134/S1087659612010178

The therapeutic potential of polymersomes loaded with 225Ac evaluated in 2D and 3D in vitro glioma models
journal, June 2018

de Kruijff, R. M.; van der Meer, A. J. G. M.; Windmeijer, C. A. A.
European Journal of Pharmaceutics and Biopharmaceutics, Vol. 127
DOI: 10.1016/j.ejpb.2018.02.008

Functionalized TiO2 nanoparticles labelled with 225Ac for targeted alpha radionuclide therapy
journal, March 2018

Cędrowska, Edyta; Pruszynski, Marek; Majkowska-Pilip, Agnieszka
Journal of Nanoparticle Research, Vol. 20, Issue 3
DOI: 10.1007/s11051-018-4181-y

Experimental α-particle radioimmunotherapy of breast cancer using 227Th-labeled p-benzyl-DOTA-trastuzumab
journal, January 2011

Abbas, Nasir; Heyerdahl, Helen; Bruland, Øyvind S.
EJNMMI Research, Vol. 1, Issue 1
DOI: 10.1186/2191-219X-1-18

Overview of RAW264.7 for osteoclastogensis study: Phenotype and stimuli
journal, March 2019

Kong, Lingbo; Smith, Wanli; Hao, Dingjun
Journal of Cellular and Molecular Medicine, Vol. 23, Issue 5
DOI: 10.1111/jcmm.14277

A comparison of radiation effects in crystalline ABO ₄ -type phosphates and silicates
journal, April 2000

Meldrum, A.; Boatner, L. A.; Ewing, R. C.
Mineralogical Magazine, Vol. 64, Issue 2
DOI: 10.1180/002646100549283

Gadolinium vanadate nanocrystals as carriers of α-emitters ( ²²⁵ Ac, ²²⁷ Th) and contrast agents
journal, June 2019

Toro-González, Miguel; Dame, Ashley N.; Mirzadeh, Saed
Journal of Applied Physics, Vol. 125, Issue 21
DOI: 10.1063/1.5096880

Effect of nanoparticle concentration on zeta-potential measurement results and reproducibility
journal, June 2010

Tantra, Ratna; Schulze, Philipp; Quincey, Paul
Particuology, Vol. 8, Issue 3
DOI: 10.1016/j.partic.2010.01.003

Lanthanide ion-doped GdPO4 nanorods with dual-modal bio-optical and magnetic resonance imaging properties
journal, January 2012

Ren, Wenlu; Tian, Gan; Zhou, Liangjun
Nanoscale, Vol. 4, Issue 12
DOI: 10.1039/c2nr30683b

Phagolysosomal pH in alveolar macrophages.
journal, July 1992

Nyberg, K.; Johansson, U.; Johansson, A.
Environmental Health Perspectives, Vol. 97
DOI: 10.1289/ehp.9297149

Facile preparation of radium-doped, functionalized nanoparticles as carriers for targeted alpha therapy
journal, January 2019

Reissig, Falco; Hübner, René; Steinbach, Jörg
Inorganic Chemistry Frontiers, Vol. 6, Issue 6
DOI: 10.1039/C9QI00208A

Polymersomes as nano-carriers to retain harmful recoil nuclides in alpha radionuclide therapy: a feasibility study
journal, July 2012

Thijssen, L.; Schaart, D. R.; de Vries, D.
Radiochimica Acta, Vol. 100, Issue 7
DOI: 10.1524/ract.2012.1935

Synthesis and Properties of Multifunctional Tetragonal Eu:GdPO ₄ Nanocubes for Optical and Magnetic Resonance Imaging Applications
journal, December 2012

Rodriguez-Liviano, Sonia; Becerro, Ana I.; Alcántara, David
Inorganic Chemistry, Vol. 52, Issue 2
DOI: 10.1021/ic3016996

Size-Dependent MRI Relaxivity and Dual Imaging with Eu _0.2 Gd _0.8 PO ₄ ·H ₂ O Nanoparticles
journal, May 2014

Li, Yichen; Chen, Tao; Tan, Weihong
Langmuir, Vol. 30, Issue 20
DOI: 10.1021/la500602x

Gold-coated lanthanide phosphate nanoparticles for an ²²⁵Ac in vivo alpha generator
journal, September 2013

McLaughlin, M. F.; Woodward, J.; Boll, R. A.
ract, Vol. 101, Issue 9
DOI: 10.1524/ract.2013.2066

Physical properties and microstructures of La $$_{1-{x}}$$ 1 - x Pr $$_{{x}}$$ x PO $$_4$$ 4 monazite-ceramics
journal, September 2017

Thust, Anja; Hirsch, Antje; Haussühl, Eiken
Physics and Chemistry of Minerals, Vol. 45, Issue 4
DOI: 10.1007/s00269-017-0921-2

Three dimensional spheroid cell culture for nanoparticle safety testing
journal, July 2015

Sambale, Franziska; Lavrentieva, Antonina; Stahl, Frank
Journal of Biotechnology, Vol. 205
DOI: 10.1016/j.jbiotec.2015.01.001

Synthesis and characterization of intrinsically radiolabeled lanthanide phosphate nanoparticles toward biomedical and environmental applications
journal, September 2018

Toro-González, M.; Clifford, D. M.; Copping, R.
Journal of Nanoparticle Research, Vol. 20, Issue 9
DOI: 10.1007/s11051-018-4338-8

Nanozeolite bioconjugates labeled with 223 Ra for targeted alpha therapy
journal, April 2017

Piotrowska, Agata; Męczyńska-Wielgosz, Sylwia; Majkowska-Pilip, Agnieszka
Nuclear Medicine and Biology, Vol. 47
DOI: 10.1016/j.nucmedbio.2016.11.005

Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
journal, January 2013

Justus, Calvin R.; Dong, Lixue; Yang, Li V.
Frontiers in Physiology, Vol. 4
DOI: 10.3389/fphys.2013.00354

Therapeutic Effect of α-Emitting 224Ra-Labeled Calcium Carbonate Microparticles in Mice with Intraperitoneal Ovarian Cancer
journal, April 2018

Westrøm, Sara; Bønsdorff, Tina B.; Bruland, Øyvind S.
Translational Oncology, Vol. 11, Issue 2
DOI: 10.1016/j.tranon.2017.12.011

Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for 223Ra and 225Ra for targeted alpha therapy
journal, July 2015

Rojas, J. V.; Woodward, J. D.; Chen, N.
Nuclear Medicine and Biology, Vol. 42, Issue 7
DOI: 10.1016/j.nucmedbio.2015.03.007

In Vitro Cytotoxicity of Low-Dose-Rate Radioimmunotherapy by the Alpha-Emitting Radioimmunoconjugate Thorium-227–DOTA–Rituximab
journal, November 2009

Dahle, Jostein; Krogh, Cecilie; Melhus, Katrine B.
International Journal of Radiation Oncology*Biology*Physics, Vol. 75, Issue 3
DOI: 10.1016/j.ijrobp.2009.04.062

A ²²⁴ Ra-labeled polyoxopalladate as a putative radiopharmaceutical
journal, January 2019

Gott, Matthew; Yang, Peng; Kortz, Ulrich
Chemical Communications, Vol. 55, Issue 53
DOI: 10.1039/C9CC02587A

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
journal, December 1983

Mosmann, Tim
Journal of Immunological Methods, Vol. 65, Issue 1-2
DOI: 10.1016/0022-1759(83)90303-4

Core/shell-type nanorods of Tb3+-doped LaPO4, modified with amine groups, revealing reduced cytotoxicity
journal, October 2013

Runowski, Marcin; Dąbrowska, Krystyna; Grzyb, Tomasz
Journal of Nanoparticle Research, Vol. 15, Issue 11
DOI: 10.1007/s11051-013-2068-5

Dynamics of Sorption—Desorption of 223Ra Therapeutic α-Emitter on Granulated Hydroxyapatite
journal, May 2019

Severin, A. V.; Vasiliev, A. N.; Gopin, A. V.
Radiochemistry, Vol. 61, Issue 3
DOI: 10.1134/S1066362219030093

Superparamagnetic iron oxide nanoparticles exert different cytotoxic effects on cells grown in monolayer cell culture versus as multicellular spheroids
journal, April 2015

Theumer, Anja; Gräfe, Christine; Bähring, Franziska
Journal of Magnetism and Magnetic Materials, Vol. 380
DOI: 10.1016/j.jmmm.2014.10.039

The effect of surface functionalization of PLGA nanoparticles by heparin- or chitosan-conjugated Pluronic on tumor targeting
journal, May 2010

Chung, Yong-Il; Kim, Jong Chul; Kim, Young Ha
Journal of Controlled Release, Vol. 143, Issue 3
DOI: 10.1016/j.jconrel.2010.01.017

Versatile Monazite: Resolving geological records and solving challenges in materials science: Monazite as a promising long-term radioactive waste matrix: Benefits of high-structural flexibility and chemical durability
journal, May 2013

Dacheux, N.; Clavier, N.; Podor, R.
American Mineralogist, Vol. 98, Issue 5-6
DOI: 10.2138/am.2013.4307

New insights into phosphate based materials for the immobilisation of actinides
journal, January 2017

Neumeier, Stefan; Arinicheva, Yulia; Ji, Yaqi
Radiochimica Acta, Vol. 105, Issue 11
DOI: 10.1515/ract-2017-2819

Initial evaluation of 227Th-p-benzyl-DOTA-rituximab for low-dose rate α-particle radioimmunotherapy
journal, February 2006

Dahle, Jostein; Borrebæk, Jørgen; Melhus, Katrine B.
Nuclear Medicine and Biology, Vol. 33, Issue 2
DOI: 10.1016/j.nucmedbio.2005.12.004

Sterically stabilized liposomes as a carrier for α-emitting radium and actinium radionuclides
journal, May 2004

Henriksen, Gjermund; Schoultz, B. W.; Michaelsen, T. E.
Nuclear Medicine and Biology, Vol. 31, Issue 4
DOI: 10.1016/j.nucmedbio.2003.11.004

Targeted cancer therapy with a novel low-dose rate α-emitting radioimmunoconjugate
journal, September 2007

Dahle, Jostein; Borrebæk, Jørgen; Jonasdottir, Thora J.
Blood, Vol. 110, Issue 6
DOI: 10.1182/blood-2007-01-066803

Displacive radiation effects in the monazite- and zircon-structure orthophosphates
journal, December 1997

Meldrum, A.; Boatner, L. A.; Ewing, R. C.
Physical Review B, Vol. 56, Issue 21
DOI: 10.1103/PhysRevB.56.13805

Mesothelin-Targeted Thorium-227 Conjugate (MSLN-TTC): Preclinical Evaluation of a New Targeted Alpha Therapy for Mesothelin-Positive Cancers
journal, May 2019

Hagemann, Urs B.; Ellingsen, Christine; Schuhmacher, Joachim
Clinical Cancer Research, Vol. 25, Issue 15
DOI: 10.1158/1078-0432.CCR-18-3476

Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles
journal, February 2014

Wang, G.; de Kruijff, R. M.; Rol, A.
Applied Radiation and Isotopes, Vol. 85
DOI: 10.1016/j.apradiso.2013.12.008

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Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for ²²³Ra and ²²⁵Ra for targeted alpha therapy

Journal Article Rojas, J. V. ; Woodward, J. D. ; Chen, N. ; ... - Nuclear Medicine and Biology

We present that targeted alpha therapy (TAT) has the potential for killing micro-metastases with minimum collateral damage to surrounding healthy tissue. In-vivo generator radionuclides, such as ²²³Ra, ²²⁵Ra, and ²²⁵Ac, are of special interest for radiotherapeutic applications as they emit multiple α-particles during their decay. Utilizing appropriate carriers capable of retaining both the parent radioisotope as well as daughter products is important for the effective delivery of the radioisotope to the tumor site while mitigating global in vivo radiotoxicity. In this article, LaPO₄ core and core + 2 shells nanoparticles (NPs) (NPs with 2 layers of cold LaPO₄ deposited onmore »« less
Cited by 42
https://doi.org/10.1016/j.nucmedbio.2015.03.007

Full Text Available
Tailoring the Radionuclide Encapsulation and Surface Chemistry of La(223Ra)VO4 Nanoparticles for Targeted Alpha Therapy

Journal Article Toro-González, Miguel ; Peacock, Allison ; Miskowiec, Andrew ; ... - Journal of Nanotheranostics

The development of targeted alpha therapy (TAT) as a viable cancer treatment requires innovative solutions to challenges associated with radionuclide retention to enhance local tumor cytotoxicity and to minimize off-target effects. Nanoparticles (NPs) with high encapsulation and high retention of radionuclides have shown potential in overcoming these issues. This article shows the influence of pH on the structure of lanthanum vanadate (LaVO₄) NPs and its impact on the radiochemical yield of ²²³Ra and subsequent retention of its decay daughters, ²¹¹Pb and ²¹¹Bi. An acidic pH (4.9) results in a high fraction of La(²²³Ra)VO₄ NPs with tetragonal structure (44.6–66.1%) and amore »« less
https://doi.org/10.3390/jnt2010003
MOUND LABORATORY PROGRESS REPORT FOR JULY 1963

Technical Report Eichelberger, J F ; Grove, G R ; Jones, L V

8 7 6 2 ; 7 4 7 6 : 7 8 : : ; half life of 3.781 plus or minus 0.010 years based on calorimetric measuiements. The calorimetric assay of the sample will be continued ior several years to decrease the probable error. The decay scheme for /sup 209/Po--/sup 209/Po/ isitopic mixtures is being determined. The gamma spectrum is being studied using two sources of different isotopic composition. Definite peaks were established at 76, 260, 300, 575, and 9l0 kev. Various multiple coincidence experiments indicated that the 300- and 575-kev photons and the 76-kev x-ray are in triplemore »« less
https://doi.org/10.2172/4026910

Full Text Available

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Title: Quantitative encapsulation and retention of 227Th and decay daughters in core–shell lanthanum phosphate nanoparticles

Abstract

Citation Formats

Probing the effect of radiation damage on the structure of rare-earth phosphates journal, December 2015

In Vitro and In Vivo Efficacy of a Novel CD33-Targeted Thorium-227 Conjugate for the Treatment of Acute Myeloid Leukemia journal, August 2016

Targeted Alpha-Particle Therapy with 227Th-Labeled Antibodies journal, September 2008

Study of 223Ra uptake mechanism by Fe3O4 nanoparticles: towards new prospective theranostic SPIONs journal, October 2016

Colloidal Synthesis of Luminescent Rhabdophane LaPO 4 :Ln 3+ · x H 2 O (Ln = Ce, Tb, Eu; x ≈ 0.7) Nanocrystals journal, September 2004

The in vivo fate of 225Ac daughter nuclides using polymersomes as a model carrier journal, August 2019

The Chemical Fate of 212Bi-DOTA Formed by β- Decay of 212Pb(DOTA)2-*** journal, January 1993

Ra-224 labeling of calcium carbonate microparticles for internal α-therapy: Preparation, stability, and biodistribution in mice journal, March 2018

Atomistic modeling and experimental studies of radiation damage in monazite-type LaPO 4 ceramics journal, February 2017

Enhanced Loading Efficiency and Retention of 225 Ac in Rigid Liposomes for Potential Targeted Therapy of Micrometastases journal, June 2008

Radiation damage in zircon and monazite journal, July 1998

Synthesis and targeting of gold-coated 177 Lu-containing lanthanide phosphate nanoparticles—A potential theranostic agent for pulmonary metastatic disease journal, March 2018

Preparation of TH 227 -Labeled Radioimmunoconjugates, Assessment of Serum Stability and Antigen Binding Ability journal, June 2007

Improved 225 Ac daughter retention in InPO 4 containing polymersomes journal, October 2017

A Proof-of-Concept Study on the Therapeutic Potential of Au Nanoparticles Radiolabeled with the Alpha-Emitter Actinium-225 journal, February 2020

Simulation of ceramic materials relevant for nuclear waste management: Case of La 1−x Eu x PO 4 solid solution journal, February 2017

Microscopic effects of self-radiation damage in 244 Cm-doped LuPO 4 crystals journal, February 2001

LaPO 4 Nanoparticles Doped with Actinium-225 that Partially Sequester Daughter Radionuclides journal, April 2011

Multifunctional GdVO 4 :Eu core–shell nanoparticles containing 225 Ac for targeted alpha therapy and molecular imaging journal, January 2018

Targeted Alpha Therapy, an Emerging Class of Cancer Agents: A Review journal, December 2018

An efficient chelator for complexation of thorium-227 journal, September 2016

Momentum Transfer to an Atom in a Molecule: Internal Excitation and Bond Dissociation journal, February 1962

Functionalized NaA nanozeolites labeled with 224,225Ra for targeted alpha therapy journal, October 2013

Targeted alpha therapy using a novel CD70 targeted thorium-227 conjugate in <i>in vitro</i> and <i>in vivo</i> models of renal cell carcinoma journal, April 2017

Hydroxyapatite particles as carriers for 223Ra journal, August 2016

Prospective carriers of 223Ra for targeted alpha particle therapy journal, September 2014

Luminescent Core/Shell Nanoparticles with a Rhabdophane LnPO4-xH2O Structure: Stabilization of Ce3+-Doped Compositions journal, February 2006

Trastuzumab Conjugated Superparamagnetic Iron Oxide Nanoparticles Labeled with 225Ac as a Perspective Tool for Combined α-Radioimmunotherapy and Magnetic Hyperthermia of HER2-Positive Breast Cancer journal, February 2020

Enhanced Retention of the α-Particle-Emitting Daughters of Actinium-225 by Liposome Carriers journal, November 2007

Radiation resistance of the xenotime YPO4 from the computer simulation data journal, February 2012

The therapeutic potential of polymersomes loaded with 225Ac evaluated in 2D and 3D in vitro glioma models journal, June 2018

Functionalized TiO2 nanoparticles labelled with 225Ac for targeted alpha radionuclide therapy journal, March 2018

Experimental α-particle radioimmunotherapy of breast cancer using 227Th-labeled p-benzyl-DOTA-trastuzumab journal, January 2011

Overview of RAW264.7 for osteoclastogensis study: Phenotype and stimuli journal, March 2019

A comparison of radiation effects in crystalline ABO 4 -type phosphates and silicates journal, April 2000

Gadolinium vanadate nanocrystals as carriers of α-emitters ( 225 Ac, 227 Th) and contrast agents journal, June 2019

Effect of nanoparticle concentration on zeta-potential measurement results and reproducibility journal, June 2010

Lanthanide ion-doped GdPO4 nanorods with dual-modal bio-optical and magnetic resonance imaging properties journal, January 2012

Phagolysosomal pH in alveolar macrophages. journal, July 1992

Facile preparation of radium-doped, functionalized nanoparticles as carriers for targeted alpha therapy journal, January 2019

Polymersomes as nano-carriers to retain harmful recoil nuclides in alpha radionuclide therapy: a feasibility study journal, July 2012

Synthesis and Properties of Multifunctional Tetragonal Eu:GdPO 4 Nanocubes for Optical and Magnetic Resonance Imaging Applications journal, December 2012

Size-Dependent MRI Relaxivity and Dual Imaging with Eu 0.2 Gd 0.8 PO 4 ·H 2 O Nanoparticles journal, May 2014

Gold-coated lanthanide phosphate nanoparticles for an 225Ac in vivo alpha generator journal, September 2013

Physical properties and microstructures of La $$_{1-{x}}$$ 1 - x Pr $$_{{x}}$$ x PO $$_4$$ 4 monazite-ceramics journal, September 2017

Three dimensional spheroid cell culture for nanoparticle safety testing journal, July 2015

Synthesis and characterization of intrinsically radiolabeled lanthanide phosphate nanoparticles toward biomedical and environmental applications journal, September 2018

Nanozeolite bioconjugates labeled with 223 Ra for targeted alpha therapy journal, April 2017

Acidic tumor microenvironment and pH-sensing G protein-coupled receptors journal, January 2013

Therapeutic Effect of α-Emitting 224Ra-Labeled Calcium Carbonate Microparticles in Mice with Intraperitoneal Ovarian Cancer journal, April 2018

Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for 223Ra and 225Ra for targeted alpha therapy journal, July 2015

In Vitro Cytotoxicity of Low-Dose-Rate Radioimmunotherapy by the Alpha-Emitting Radioimmunoconjugate Thorium-227–DOTA–Rituximab journal, November 2009

A 224 Ra-labeled polyoxopalladate as a putative radiopharmaceutical journal, January 2019

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays journal, December 1983

Core/shell-type nanorods of Tb3+-doped LaPO4, modified with amine groups, revealing reduced cytotoxicity journal, October 2013

Dynamics of Sorption—Desorption of 223Ra Therapeutic α-Emitter on Granulated Hydroxyapatite journal, May 2019

Superparamagnetic iron oxide nanoparticles exert different cytotoxic effects on cells grown in monolayer cell culture versus as multicellular spheroids journal, April 2015

The effect of surface functionalization of PLGA nanoparticles by heparin- or chitosan-conjugated Pluronic on tumor targeting journal, May 2010

Versatile Monazite: Resolving geological records and solving challenges in materials science: Monazite as a promising long-term radioactive waste matrix: Benefits of high-structural flexibility and chemical durability journal, May 2013

New insights into phosphate based materials for the immobilisation of actinides journal, January 2017

Initial evaluation of 227Th-p-benzyl-DOTA-rituximab for low-dose rate α-particle radioimmunotherapy journal, February 2006

Sterically stabilized liposomes as a carrier for α-emitting radium and actinium radionuclides journal, May 2004

Targeted cancer therapy with a novel low-dose rate α-emitting radioimmunoconjugate journal, September 2007

Displacive radiation effects in the monazite- and zircon-structure orthophosphates journal, December 1997

Mesothelin-Targeted Thorium-227 Conjugate (MSLN-TTC): Preclinical Evaluation of a New Targeted Alpha Therapy for Mesothelin-Positive Cancers journal, May 2019

Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles journal, February 2014

Title: Quantitative encapsulation and retention of ²²⁷Th and decay daughters in core–shell lanthanum phosphate nanoparticles

Probing the effect of radiation damage on the structure of rare-earth phosphates
journal, December 2015

In Vitro and In Vivo Efficacy of a Novel CD33-Targeted Thorium-227 Conjugate for the Treatment of Acute Myeloid Leukemia
journal, August 2016

Targeted Alpha-Particle Therapy with 227Th-Labeled Antibodies
journal, September 2008

Study of 223Ra uptake mechanism by Fe3O4 nanoparticles: towards new prospective theranostic SPIONs
journal, October 2016

Colloidal Synthesis of Luminescent Rhabdophane LaPO ₄ :Ln ³⁺ · x H ₂ O (Ln = Ce, Tb, Eu; x ≈ 0.7) Nanocrystals
journal, September 2004

The in vivo fate of 225Ac daughter nuclides using polymersomes as a model carrier
journal, August 2019

The Chemical Fate of 212Bi-DOTA Formed by β- Decay of 212Pb(DOTA)2-***
journal, January 1993

Ra-224 labeling of calcium carbonate microparticles for internal α-therapy: Preparation, stability, and biodistribution in mice
journal, March 2018

Atomistic modeling and experimental studies of radiation damage in monazite-type LaPO 4 ceramics
journal, February 2017

Enhanced Loading Efficiency and Retention of ²²⁵ Ac in Rigid Liposomes for Potential Targeted Therapy of Micrometastases
journal, June 2008

Radiation damage in zircon and monazite
journal, July 1998

Synthesis and targeting of gold-coated ¹⁷⁷ Lu-containing lanthanide phosphate nanoparticles—A potential theranostic agent for pulmonary metastatic disease
journal, March 2018

Preparation of TH ²²⁷ -Labeled Radioimmunoconjugates, Assessment of Serum Stability and Antigen Binding Ability
journal, June 2007

Improved 225 Ac daughter retention in InPO 4 containing polymersomes
journal, October 2017

A Proof-of-Concept Study on the Therapeutic Potential of Au Nanoparticles Radiolabeled with the Alpha-Emitter Actinium-225
journal, February 2020

Simulation of ceramic materials relevant for nuclear waste management: Case of La 1−x Eu x PO 4 solid solution
journal, February 2017

Microscopic effects of self-radiation damage in ²⁴⁴ Cm-doped LuPO ₄ crystals
journal, February 2001

LaPO ₄ Nanoparticles Doped with Actinium-225 that Partially Sequester Daughter Radionuclides
journal, April 2011

Multifunctional GdVO ₄ :Eu core–shell nanoparticles containing ²²⁵ Ac for targeted alpha therapy and molecular imaging
journal, January 2018

Targeted Alpha Therapy, an Emerging Class of Cancer Agents: A Review
journal, December 2018

An efficient chelator for complexation of thorium-227
journal, September 2016

Momentum Transfer to an Atom in a Molecule: Internal Excitation and Bond Dissociation
journal, February 1962

Functionalized NaA nanozeolites labeled with 224,225Ra for targeted alpha therapy
journal, October 2013

Targeted alpha therapy using a novel CD70 targeted thorium-227 conjugate in <i>in vitro</i> and <i>in vivo</i> models of renal cell carcinoma
journal, April 2017

Hydroxyapatite particles as carriers for 223Ra
journal, August 2016

Prospective carriers of 223Ra for targeted alpha particle therapy
journal, September 2014

Luminescent Core/Shell Nanoparticles with a Rhabdophane LnPO4-xH2O Structure: Stabilization of Ce3+-Doped Compositions
journal, February 2006

Trastuzumab Conjugated Superparamagnetic Iron Oxide Nanoparticles Labeled with 225Ac as a Perspective Tool for Combined α-Radioimmunotherapy and Magnetic Hyperthermia of HER2-Positive Breast Cancer
journal, February 2020

Enhanced Retention of the α-Particle-Emitting Daughters of Actinium-225 by Liposome Carriers
journal, November 2007

Radiation resistance of the xenotime YPO4 from the computer simulation data
journal, February 2012

The therapeutic potential of polymersomes loaded with 225Ac evaluated in 2D and 3D in vitro glioma models
journal, June 2018

Functionalized TiO2 nanoparticles labelled with 225Ac for targeted alpha radionuclide therapy
journal, March 2018

Experimental α-particle radioimmunotherapy of breast cancer using 227Th-labeled p-benzyl-DOTA-trastuzumab
journal, January 2011

Overview of RAW264.7 for osteoclastogensis study: Phenotype and stimuli
journal, March 2019

A comparison of radiation effects in crystalline ABO ₄ -type phosphates and silicates
journal, April 2000

Gadolinium vanadate nanocrystals as carriers of α-emitters ( ²²⁵ Ac, ²²⁷ Th) and contrast agents
journal, June 2019

Effect of nanoparticle concentration on zeta-potential measurement results and reproducibility
journal, June 2010

Lanthanide ion-doped GdPO4 nanorods with dual-modal bio-optical and magnetic resonance imaging properties
journal, January 2012

Phagolysosomal pH in alveolar macrophages.
journal, July 1992

Facile preparation of radium-doped, functionalized nanoparticles as carriers for targeted alpha therapy
journal, January 2019

Polymersomes as nano-carriers to retain harmful recoil nuclides in alpha radionuclide therapy: a feasibility study
journal, July 2012

Synthesis and Properties of Multifunctional Tetragonal Eu:GdPO ₄ Nanocubes for Optical and Magnetic Resonance Imaging Applications
journal, December 2012

Size-Dependent MRI Relaxivity and Dual Imaging with Eu _0.2 Gd _0.8 PO ₄ ·H ₂ O Nanoparticles
journal, May 2014

Gold-coated lanthanide phosphate nanoparticles for an ²²⁵Ac in vivo alpha generator
journal, September 2013

Physical properties and microstructures of La $$_{1-{x}}$$ 1 - x Pr $$_{{x}}$$ x PO $$_4$$ 4 monazite-ceramics
journal, September 2017

Three dimensional spheroid cell culture for nanoparticle safety testing
journal, July 2015

Synthesis and characterization of intrinsically radiolabeled lanthanide phosphate nanoparticles toward biomedical and environmental applications
journal, September 2018

Nanozeolite bioconjugates labeled with 223 Ra for targeted alpha therapy
journal, April 2017

Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
journal, January 2013

Therapeutic Effect of α-Emitting 224Ra-Labeled Calcium Carbonate Microparticles in Mice with Intraperitoneal Ovarian Cancer
journal, April 2018

Synthesis and characterization of lanthanum phosphate nanoparticles as carriers for 223Ra and 225Ra for targeted alpha therapy
journal, July 2015

In Vitro Cytotoxicity of Low-Dose-Rate Radioimmunotherapy by the Alpha-Emitting Radioimmunoconjugate Thorium-227–DOTA–Rituximab
journal, November 2009

A ²²⁴ Ra-labeled polyoxopalladate as a putative radiopharmaceutical
journal, January 2019

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
journal, December 1983

Core/shell-type nanorods of Tb3+-doped LaPO4, modified with amine groups, revealing reduced cytotoxicity
journal, October 2013

Dynamics of Sorption—Desorption of 223Ra Therapeutic α-Emitter on Granulated Hydroxyapatite
journal, May 2019

Superparamagnetic iron oxide nanoparticles exert different cytotoxic effects on cells grown in monolayer cell culture versus as multicellular spheroids
journal, April 2015

The effect of surface functionalization of PLGA nanoparticles by heparin- or chitosan-conjugated Pluronic on tumor targeting
journal, May 2010

Versatile Monazite: Resolving geological records and solving challenges in materials science: Monazite as a promising long-term radioactive waste matrix: Benefits of high-structural flexibility and chemical durability
journal, May 2013

New insights into phosphate based materials for the immobilisation of actinides
journal, January 2017

Initial evaluation of 227Th-p-benzyl-DOTA-rituximab for low-dose rate α-particle radioimmunotherapy
journal, February 2006

Sterically stabilized liposomes as a carrier for α-emitting radium and actinium radionuclides
journal, May 2004

Targeted cancer therapy with a novel low-dose rate α-emitting radioimmunoconjugate
journal, September 2007

Displacive radiation effects in the monazite- and zircon-structure orthophosphates
journal, December 1997

Mesothelin-Targeted Thorium-227 Conjugate (MSLN-TTC): Preclinical Evaluation of a New Targeted Alpha Therapy for Mesothelin-Positive Cancers
journal, May 2019

Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles
journal, February 2014