Crystal structure of N-{N-[N-acetyl-(S)-leucyl]-(S)-leucyl}norleucinal (ALLN), an inhibitor of proteasome
Abstract
The title compound, C20H37N3O4, also known by the acronym ALLN, is a tripeptidic inhibitor of the proteolytic activity of the proteasomes, enzyme complexes implicated in several neurodegenerative diseases and other disorders, including cancer. Thus, the crystal structure of ALLN, solved from synchrotron radiation diffraction data, revealed the molecules in extended conformation of the backbone and engaging all peptide N and O atoms in intermolecular hydrogen bonds forming an infinite antiparallel β-sheet.
- Authors:
-
- Peptides International, Inc., Louisville, KY (United States)
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Publication Date:
- Research Org.:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1225201
- Grant/Contract Number:
- AC02-06CH11357; W-31-109-ENG-38
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Acta Crystallographica. Section E, Crystallographic Communications
- Additional Journal Information:
- Journal Volume: 71; Journal Issue: 3; Journal ID: ISSN 2056-9890
- Publisher:
- International Union of Crystallography
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; crystal structure; proteasome inhibitor; hydrogen bonding; antiparallel β-sheet
Citation Formats
Czerwinski, Andrzej, Basava, Channa, Dauter, Miroslawa, and Dauter, Zbigniew. Crystal structure of N-{N-[N-acetyl-(S)-leucyl]-(S)-leucyl}norleucinal (ALLN), an inhibitor of proteasome. United States: N. p., 2015.
Web. doi:10.1107/S2056989015002091.
Czerwinski, Andrzej, Basava, Channa, Dauter, Miroslawa, & Dauter, Zbigniew. Crystal structure of N-{N-[N-acetyl-(S)-leucyl]-(S)-leucyl}norleucinal (ALLN), an inhibitor of proteasome. United States. https://doi.org/10.1107/S2056989015002091
Czerwinski, Andrzej, Basava, Channa, Dauter, Miroslawa, and Dauter, Zbigniew. Sun .
"Crystal structure of N-{N-[N-acetyl-(S)-leucyl]-(S)-leucyl}norleucinal (ALLN), an inhibitor of proteasome". United States. https://doi.org/10.1107/S2056989015002091. https://www.osti.gov/servlets/purl/1225201.
@article{osti_1225201,
title = {Crystal structure of N-{N-[N-acetyl-(S)-leucyl]-(S)-leucyl}norleucinal (ALLN), an inhibitor of proteasome},
author = {Czerwinski, Andrzej and Basava, Channa and Dauter, Miroslawa and Dauter, Zbigniew},
abstractNote = {The title compound, C20H37N3O4, also known by the acronym ALLN, is a tripeptidic inhibitor of the proteolytic activity of the proteasomes, enzyme complexes implicated in several neurodegenerative diseases and other disorders, including cancer. Thus, the crystal structure of ALLN, solved from synchrotron radiation diffraction data, revealed the molecules in extended conformation of the backbone and engaging all peptide N and O atoms in intermolecular hydrogen bonds forming an infinite antiparallel β-sheet.},
doi = {10.1107/S2056989015002091},
journal = {Acta Crystallographica. Section E, Crystallographic Communications},
number = 3,
volume = 71,
place = {United States},
year = {Sun Mar 01 00:00:00 EST 2015},
month = {Sun Mar 01 00:00:00 EST 2015}
}
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Figure 1: The molecule of ALLN, showing the atom-labelling scheme. Displacement ellipsoids are drawn at the 50% probability level.
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Works referencing / citing this record:
Ceramide Induces the Death of Retina Photoreceptors Through Activation of Parthanatos
journal, November 2018
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Figures / Tables found in this record:
Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.