Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung
Abstract
Method using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with .sup.67 Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the situs thereof by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the .sup.67 Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques cna be used to locate the malignant tissue mass.
- Inventors:
-
- 60 San Juan St., Los Alamos, NM 87544
- (402 Pine Tree La., Boulder, CO 80304)
- 694 Sperber La., Grand Junction, CO 81506
- 715 Victor Dr., Grand Junction, CO 81506
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- OSTI Identifier:
- 868533
- Patent Number(s):
- 5162231
- Assignee:
- Cole, Dean A. (60 San Juan St., Los Alamos, NM 87544);Moody, III, David C. (402 Pine Tree La., Boulder, CO 80304);Ellinwood, L. Edward (694 Sperber La., Grand Junction, CO 81506);Klein, M. Gerard (715 Victor Dr., Grand Junction, CO 81506)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- W-7405-ENG-36
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- method; 10; 15; 20-tetrakis; carboxyphenyl; porphine; detecting; cancers; lung; tetra-aryl; porphyrins; particular; 4-carboxyphenyl; fluorescent; tracer; radiotracer; complex; 67; cu; latter; provides; source; beta; radiation; selective; destruction; malignancies; gamma; useful; image; analysis; situs; single; photon; emission; computed; tomography; example; vivo; copper-64; substituted; characteristics; lighter; isotope; copper; positron; emitter; techniques; cna; locate; malignant; tissue; mass; computed tomography; gamma radiation; emission tomography; positron emission; photon emission; beta radiation; single photon; emission computed; tomography techniques; positron emitter; tissue mass; image analysis; tetra-aryl porphyrins; fluorescent tracer; malignant tissue; /436/376/435/514/
Citation Formats
Cole, Dean A, Moody, III, David C., Ellinwood, L Edward, and Klein, M Gerard. Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung. United States: N. p., 1992.
Web.
Cole, Dean A, Moody, III, David C., Ellinwood, L Edward, & Klein, M Gerard. Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung. United States.
Cole, Dean A, Moody, III, David C., Ellinwood, L Edward, and Klein, M Gerard. Wed .
"Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung". United States. https://www.osti.gov/servlets/purl/868533.
@article{osti_868533,
title = {Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung},
author = {Cole, Dean A and Moody, III, David C. and Ellinwood, L Edward and Klein, M Gerard},
abstractNote = {Method using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with .sup.67 Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the situs thereof by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the .sup.67 Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques cna be used to locate the malignant tissue mass.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Jan 01 00:00:00 EST 1992},
month = {Wed Jan 01 00:00:00 EST 1992}
}
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