Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung
Abstract
A method is described for using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with [sup 67]Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the lungs by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the [sup 67]Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques can be used to locate the malignant tissue mass. 1 figure.
- Inventors:
- Issue Date:
- OSTI Identifier:
- 7117152
- Patent Number(s):
- 5162231
- Application Number:
- PPN: US 7-539999
- Assignee:
- PTO; EDB-94-091192
- DOE Contract Number:
- W-7405-ENG-36
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 15 Jun 1990
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; LUNGS; NEOPLASMS; DIAGNOSIS; RADIOTHERAPY; RADIOPHARMACEUTICALS; CHEMICAL PREPARATION; COPPER 64; COPPER 67; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; COPPER ISOTOPES; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; LABELLED COMPOUNDS; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIOISOTOPES; RADIOLOGY; RESPIRATORY SYSTEM; SYNTHESIS; THERAPY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)
Citation Formats
Cole, D A, Moody, III, D C, Ellinwood, L E, and Klein, M G. Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung. United States: N. p., 1992.
Web.
Cole, D A, Moody, III, D C, Ellinwood, L E, & Klein, M G. Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung. United States.
Cole, D A, Moody, III, D C, Ellinwood, L E, and Klein, M G. Tue .
"Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung". United States.
@article{osti_7117152,
title = {Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung},
author = {Cole, D A and Moody, III, D C and Ellinwood, L E and Klein, M G},
abstractNote = {A method is described for using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with [sup 67]Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the lungs by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the [sup 67]Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques can be used to locate the malignant tissue mass. 1 figure.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 10 00:00:00 EST 1992},
month = {Tue Nov 10 00:00:00 EST 1992}
}
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