Process for the production of .sup.18 F-2-deoxy-2-fluoro-D-glucose
Abstract
Process for the production of 2-deoxy-2-fluoro-D-glucose and the corresponding .sup.18 F-compound in which methyl 4,6-O-benzylidine-3-O-methyl-2-O-trifluoromethanesulfonyl-.beta.-D-mannopy ranoside is reacted with a triflating reagent, the resulting compound reacted with CsHF.sub.2, RbF or the corresponding .sup.18 F-compounds, and thereafter the alkyl groups removed by hydrolysis.
- Inventors:
-
- Brookline, MA
- Jerusalem, IL
- East Setauket, NY
- Setauket, NY
- Issue Date:
- Research Org.:
- Associated Universities, Inc., Upton, NY (United States)
- OSTI Identifier:
- 866024
- Patent Number(s):
- 4617386
- Assignee:
- United States of America as represented by United States (Washington, DC)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- process; production; sup18; f-2-deoxy-2-fluoro-d-glucose; 2-deoxy-2-fluoro-d-glucose; corresponding; f-compound; methyl; 46-o-benzylidine-3-o-methyl-2-o-trifluoromethanesulfonyl-beta-d-mannopy; ranoside; reacted; triflating; reagent; resulting; compound; cshfsub2; rbf; f-compounds; thereafter; alkyl; removed; hydrolysis; /999/
Citation Formats
Elmaleh, David R, Levy, Shlomo, Shiue, Chyng-Yann, and Wolf, Alfred P. Process for the production of .sup.18 F-2-deoxy-2-fluoro-D-glucose. United States: N. p., 1986.
Web.
Elmaleh, David R, Levy, Shlomo, Shiue, Chyng-Yann, & Wolf, Alfred P. Process for the production of .sup.18 F-2-deoxy-2-fluoro-D-glucose. United States.
Elmaleh, David R, Levy, Shlomo, Shiue, Chyng-Yann, and Wolf, Alfred P. Wed .
"Process for the production of .sup.18 F-2-deoxy-2-fluoro-D-glucose". United States. https://www.osti.gov/servlets/purl/866024.
@article{osti_866024,
title = {Process for the production of .sup.18 F-2-deoxy-2-fluoro-D-glucose},
author = {Elmaleh, David R and Levy, Shlomo and Shiue, Chyng-Yann and Wolf, Alfred P},
abstractNote = {Process for the production of 2-deoxy-2-fluoro-D-glucose and the corresponding .sup.18 F-compound in which methyl 4,6-O-benzylidine-3-O-methyl-2-O-trifluoromethanesulfonyl-.beta.-D-mannopy ranoside is reacted with a triflating reagent, the resulting compound reacted with CsHF.sub.2, RbF or the corresponding .sup.18 F-compounds, and thereafter the alkyl groups removed by hydrolysis.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Jan 01 00:00:00 EST 1986},
month = {Wed Jan 01 00:00:00 EST 1986}
}
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