Laser-induced differential normalized fluorescence method for cancer diagnosis
Abstract
An apparatus and method for cancer diagnosis are disclosed. The diagnostic method includes the steps of irradiating a tissue sample with monochromatic excitation light, producing a laser-induced fluorescence spectrum from emission radiation generated by interaction of the excitation light with the tissue sample, and dividing the intensity at each wavelength of the laser-induced fluorescence spectrum by the integrated area under the laser-induced fluorescence spectrum to produce a normalized spectrum. A mathematical difference between the normalized spectrum and an average value of a reference set of normalized spectra which correspond to normal tissues is calculated, which provides for amplifying small changes in weak signals from malignant tissues for improved analysis. The calculated differential normalized spectrum is correlated to a specific condition of a tissue sample. 5 figs.
- Inventors:
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- OSTI Identifier:
- 415747
- Patent Number(s):
- 5579773
- Application Number:
- PAN: 8-316,132
- Assignee:
- Martin Marietta Energy Systems, Inc., Oak Ridge, TN (United States)
- DOE Contract Number:
- AC05-84OR21400
- Resource Type:
- Patent
- Resource Relation:
- Other Information: PBD: 3 Dec 1996
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 55 BIOLOGY AND MEDICINE, BASIC STUDIES; LASER RADIATION; DIAGNOSTIC USES; NEOPLASMS; DIAGNOSIS; FLUORESCENCE SPECTROSCOPY
Citation Formats
Vo-Dinh, T, Panjehpour, M, and Overholt, B F. Laser-induced differential normalized fluorescence method for cancer diagnosis. United States: N. p., 1996.
Web.
Vo-Dinh, T, Panjehpour, M, & Overholt, B F. Laser-induced differential normalized fluorescence method for cancer diagnosis. United States.
Vo-Dinh, T, Panjehpour, M, and Overholt, B F. Tue .
"Laser-induced differential normalized fluorescence method for cancer diagnosis". United States.
@article{osti_415747,
title = {Laser-induced differential normalized fluorescence method for cancer diagnosis},
author = {Vo-Dinh, T and Panjehpour, M and Overholt, B F},
abstractNote = {An apparatus and method for cancer diagnosis are disclosed. The diagnostic method includes the steps of irradiating a tissue sample with monochromatic excitation light, producing a laser-induced fluorescence spectrum from emission radiation generated by interaction of the excitation light with the tissue sample, and dividing the intensity at each wavelength of the laser-induced fluorescence spectrum by the integrated area under the laser-induced fluorescence spectrum to produce a normalized spectrum. A mathematical difference between the normalized spectrum and an average value of a reference set of normalized spectra which correspond to normal tissues is calculated, which provides for amplifying small changes in weak signals from malignant tissues for improved analysis. The calculated differential normalized spectrum is correlated to a specific condition of a tissue sample. 5 figs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Dec 03 00:00:00 EST 1996},
month = {Tue Dec 03 00:00:00 EST 1996}
}