Microorganisms that co-consume glucose with non-glucose carbohydrates and methods of use

Reed, Jennifer L.; Kim, Joonhoon

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A - human necessities
A01 - agriculture
A21 - baking
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Title: Microorganisms that co-consume glucose with non-glucose carbohydrates and methods of use

Abstract

Microorganisms that co-consume glucose with non-glucose carbohydrates, such as xylose, and methods of using same. The microorganisms comprise modifications that reduce or ablate the activity of a phosphoenolpyruvate (PEP):carbohydrate phosphotransferase system (PTS) protein or modifications that reduce or ablate the activity of a phosphoglucose isomerase and a GntR. The PTS protein may be selected from an enzyme I (EI), an HPr, an FPr, and an enzyme IIGlc (EIIGlc). Additional modifications include reduction or ablation of the activity of a pyruvate formate lyase, a lactate dehydrogenase, and a fumarate reductase and inclusion of recombinant pyruvate decarboxylase and alcohol dehydrogenase genes. The microorganisms are particularly suited to co-consuming glucose and xylose in media containing these substrates and producing ethanol therefrom.

Inventors:: Reed, Jennifer L.; Kim, Joonhoon

Issue Date:: Tue May 28 00:00:00 EDT 2019

Research Org.:: Wisconsin Alumni Research Foundation, Madison, WI (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1568392

Patent Number(s):: 10301653

Application Number:: 14/791,590

Assignee:: Wisconsin Alumni Research Foundation (Madison, WI)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/245 - Escherichia

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N1/14 - Fungi
C12N1/20 - Bacteria {
C12N9/0006 - {acting on CH-OH groups as donors
C12N9/1205 - {Phosphotransferases with an alcohol group as acceptor
C12N9/88 - Lyases
C12N9/92 - Glucose isomerase {

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C12P7/06 - Ethanol, i.e. non-beverage
C12P7/065 - {with microorganisms other than yeasts}
C12P7/10 - substrate containing cellulosic material

C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES
C12Y101/01001 - Alcohol dehydrogenase
C12Y401/01001 - Pyruvate decarboxylase

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02E - REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
Y02E50/10 - Biofuels

Show less

DOE Contract Number:: FC02-07ER64494

Resource Type:: Patent

Resource Relation:: Patent File Date: 07/06/2015

Country of Publication:: United States

Language:: English

Subject:: 09 BIOMASS FUELS; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Reed, Jennifer L., and Kim, Joonhoon. Microorganisms that co-consume glucose with non-glucose carbohydrates and methods of use.  United States: N. p., 2019. 
        Web.

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                    Reed, Jennifer L., & Kim, Joonhoon. Microorganisms that co-consume glucose with non-glucose carbohydrates and methods of use.  United States.

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                    Reed, Jennifer L., and Kim, Joonhoon. Tue .  
        "Microorganisms that co-consume glucose with non-glucose carbohydrates and methods of use".  United States.  https://www.osti.gov/servlets/purl/1568392.

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@article{osti_1568392,

  title        = {Microorganisms that co-consume glucose with non-glucose carbohydrates and methods of use},

  author       = {Reed, Jennifer L. and Kim, Joonhoon},

  abstractNote = {Microorganisms that co-consume glucose with non-glucose carbohydrates, such as xylose, and methods of using same. The microorganisms comprise modifications that reduce or ablate the activity of a phosphoenolpyruvate (PEP):carbohydrate phosphotransferase system (PTS) protein or modifications that reduce or ablate the activity of a phosphoglucose isomerase and a GntR. The PTS protein may be selected from an enzyme I (EI), an HPr, an FPr, and an enzyme IIGlc (EIIGlc). Additional modifications include reduction or ablation of the activity of a pyruvate formate lyase, a lactate dehydrogenase, and a fumarate reductase and inclusion of recombinant pyruvate decarboxylase and alcohol dehydrogenase genes. The microorganisms are particularly suited to co-consuming glucose and xylose in media containing these substrates and producing ethanol therefrom.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue May 28 00:00:00 EDT 2019},

  month        = {Tue May 28 00:00:00 EDT 2019}

}

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Similar Records

Title: Microorganisms that co-consume glucose with non-glucose carbohydrates and methods of use

Abstract

Citation Formats

Escherichia coli containing mutated lpdA gene and application thereof patent-application, May 2016

Autonomous replication sequences for yeast strains of the genus pichia patent, June 1989

Genetically Modified Microorganism for Improved Production of Fine Chemicals on Sucrose patent-application, March 2017

L-malate production by metabolically engineered escherichia coli patent, November 2015

L-malate production by metabolically engineered Escherichia coli patent-application, June 2013

Recombinant microorganism for the production of useful metabolites patent-application, September 2014

Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds patent-application, June 2017

Polypeptide having glyoxalase III activity, polynucleotide encoding the same and uses thereof patent-application, January 2011

Engineering the pathway for succinate production patent-application, March 2012

Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing succinate related thereto patent-application, March 2016

Metabolic evolution of Escherichia coli strains that produce organic acids patent-application, March 2016

Primary alcohol producing organisms patent, February 2016

Ethanol-producing microorganisms and methods of using patent-application, October 2010

Glucose and xylose co-utilization in E. coli patent-application, August 2015

Recombinant Escherichia coli for producing succinic acid and application thereof patent-application, April 2016

Substrate-selective co-fermentation process patent-application, December 2012

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Production of Malonyl-CoA Derived Products Via Anaerobic Pathways patent-application, December 2013

Methods and organisms with increased carbon flux efficiencies patent-application, November 2016

Escherichia coli containing mutated lpdA gene and application thereof
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Autonomous replication sequences for yeast strains of the genus pichia
patent, June 1989

Genetically Modified Microorganism for Improved Production of Fine Chemicals on Sucrose
patent-application, March 2017

L-malate production by metabolically engineered escherichia coli
patent, November 2015

L-malate production by metabolically engineered Escherichia coli
patent-application, June 2013

Recombinant microorganism for the production of useful metabolites
patent-application, September 2014

Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
patent-application, June 2017

Polypeptide having glyoxalase III activity, polynucleotide encoding the same and uses thereof
patent-application, January 2011

Engineering the pathway for succinate production
patent-application, March 2012

Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing succinate related thereto
patent-application, March 2016

Metabolic evolution of Escherichia coli strains that produce organic acids
patent-application, March 2016

Primary alcohol producing organisms
patent, February 2016

Ethanol-producing microorganisms and methods of using
patent-application, October 2010

Glucose and xylose co-utilization in E. coli
patent-application, August 2015

Recombinant Escherichia coli for producing succinic acid and application thereof
patent-application, April 2016

Substrate-selective co-fermentation process
patent-application, December 2012

Method of producing succinic acid and other chemicals using facilitated diffusion for sugar import
patent-application, June 2016

Escherichia coli containing mutated lpdA gene and application thereof
patent, March 2017

Biocatalysts and methods for conversion of hemicellulose hydrolysates to biobased products
patent-application, August 2011

Method for Simultaneous Fermentation of Pentose and Hexose
patent-application, June 2013

Methylmalonic acid compositions, biological methods for making same, and microorganisms for making same
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Pichia transformation
patent, May 1990

Production of Malonyl-CoA Derived Products Via Anaerobic Pathways
patent-application, December 2013

Methods and organisms with increased carbon flux efficiencies
patent-application, November 2016