Contrast enhancing solution for use in confocal microscopy
Abstract
A method of optically detecting a tumor during surgery. The method includes imaging at least one test point defined on the tumor using a first optical imaging system to provide a first tumor image. The method further includes excising a first predetermined layer of the tumor for forming an in-vivo defect area. A predetermined contrast enhancing solution is disposed on the in-vivo defect area, which is adapted to interact with at least one cell anomaly, such as basal cell carcinoma, located on the in-vivo defect area for optically enhancing the cell anomaly. Thereafter the defect area can be optically imaged to provide a clear and bright representation of the cell anomaly to aid a surgeon while surgically removing the cell anomaly.
- Inventors:
- Issue Date:
- Research Org.:
- Massachusetts General Hospital, Boston, MA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1175965
- Patent Number(s):
- 7128894
- Application Number:
- 10/607,630
- Assignee:
- The United States of America as represented by the United States Department of Energy (Washington, DC)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- FG02-91ER61228
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2003 Jun 27
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Tannous, Zeina, Torres, Abel, and Gonzalez, Salvador. Contrast enhancing solution for use in confocal microscopy. United States: N. p., 2006.
Web.
Tannous, Zeina, Torres, Abel, & Gonzalez, Salvador. Contrast enhancing solution for use in confocal microscopy. United States.
Tannous, Zeina, Torres, Abel, and Gonzalez, Salvador. Tue .
"Contrast enhancing solution for use in confocal microscopy". United States. https://www.osti.gov/servlets/purl/1175965.
@article{osti_1175965,
title = {Contrast enhancing solution for use in confocal microscopy},
author = {Tannous, Zeina and Torres, Abel and Gonzalez, Salvador},
abstractNote = {A method of optically detecting a tumor during surgery. The method includes imaging at least one test point defined on the tumor using a first optical imaging system to provide a first tumor image. The method further includes excising a first predetermined layer of the tumor for forming an in-vivo defect area. A predetermined contrast enhancing solution is disposed on the in-vivo defect area, which is adapted to interact with at least one cell anomaly, such as basal cell carcinoma, located on the in-vivo defect area for optically enhancing the cell anomaly. Thereafter the defect area can be optically imaged to provide a clear and bright representation of the cell anomaly to aid a surgeon while surgically removing the cell anomaly.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 31 00:00:00 EST 2006},
month = {Tue Oct 31 00:00:00 EST 2006}
}
Works referenced in this record:
In Vivo Confocal Scanning Laser Microscopy of Human Skin II: Advances in Instrumentation and Comparison With Histology11The authors have declared conflict of interest.
journal, September 1999
- Rajadhyaksha, Milind; González, Salvador; Zavislan, James M.
- Journal of Investigative Dermatology, Vol. 113, Issue 3