Complex of transferrin with ruthenium for medical applications

Patent · Tue May 15 00:00:00 EDT 1984

OSTI ID:865008

Richards, Powell ^[1]; Srivastava, Suresh C ^[2]; Meinken, George E ^[3]

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1. Bayport, NY
2. Setauket, NY
3. Middle Island, NY

A novel Ruthenium-transferrin complex, prepared by reacting iron-free human transferrin dissolved in a sodium acetate solution at pH 7 with ruthenium by heating at about 40.degree. C. for about 2 hours, and purifying said complex by means of gel chromotography with pH 7 sodium acetate as eluent. The mono- or di-metal complex produced can be used in nuclear medicine in the diagnosis and/or treatment of tumors and abscesses. Comparative results with Ga-67-citrate, which is the most widely used tumor-localizing agent in nuclear medicine, indicate increased sensitivity of detection and greater tumor uptake with the Ru-transferrin complex.

• Research Organization: Associated Universities, Inc., Upton, NY (United States)
• DOE Contract Number: AC02-76CH00016
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 4448762
• Application Number: 06/203,194
• OSTI ID: 865008
• Country of Publication: United States
• Language: English

Related Subjects

complex
transferrin
ruthenium
medical
applications
novel
ruthenium-transferrin
prepared
reacting
iron-free
human
dissolved
sodium
acetate
solution
ph
heating
40
degree
hours
purifying
means
chromotography
eluent
mono-
di-metal
produced
nuclear
medicine
diagnosis
treatment
tumors
abscesses
comparative
results
ga-67-citrate
widely
tumor-localizing
agent
indicate
increased
sensitivity
detection
tumor
uptake
ru-transferrin
increased sensitivity
medical applications
nuclear medicine
metal complex
sodium acetate
tumor uptake
acetate solution
/424/530/