Complex of transferrin with ruthenium for medical applications. [Ru 97, Ru 103]

Patent · Mon Nov 03 00:00:00 EST 1980

OSTI ID:5176384

Richards, P; Srivastava, S C; Meinken, G E

A novel Ruthenium-transferrin complex, prepared by reacting iron-free human transferrin dissolved in a sodium acetate solution at pH 7 with ruthenium by heating at about 40/sup 0/C for about 2 hours, and purifying said complex by means of gel chromatography with pH 7 sodium acetate as eluent. The mono- or di-metal complex produced can be used in nuclear medicine in the diagnosis and/or treatment of tumors and abscesses. Comparitive results with Ga-67-citrate, which is the most widely used tumor-localizing agent in nuclear medicine, indicate increased sensitivity of detection and greater tumor uptake with the Ru-transferrin complex.

• DOE Contract Number: EY-76-C-02-0016
• Assignee: Dept. of Energy
• OSTI ID: 5176384
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
RUTHENIUM 103
RUTHENIUM 97
DIAGNOSTIC USES
RADIATION SOURCE IMPLANTS
TRANSFERRIN
LABELLING
BIOLOGICAL LOCALIZATION
CITRIC ACID ESTERS
COMPARATIVE EVALUATIONS
GALLIUM 67
INFLAMMATION
INTERNAL IRRADIATION
LABELLED COMPOUNDS
NEOPLASMS
RADIONUCLIDE KINETICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACID ESTERS
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
EVEN-ODD NUCLEI
GALLIUM ISOTOPES
GLOBULINS
GLOBULINS-BETA
IMPLANTS
INTERMEDIATE MASS NUCLEI
IRRADIATION
ISOTOPES
METALLOPROTEINS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PROTEINS
RADIATION SOURCES
RADIOISOTOPES
RUTHENIUM ISOTOPES
SYMPTOMS
SYNTHESIS
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials