Radiation-induced intracranial malignant fibrous histiocytoma

Journal Article · Tue Jun 01 00:00:00 EDT 1976 · Cancer; (United States)

DOI:https://doi.org/10.1002/1097-0142(197606)37:6<2960::AID-CNCR2820370653>3.0.CO;2-2· OSTI ID:7349017

Gonzalez-Vitale, J C; Slavin, R E; McQueen, J D

An autopsy case of radiation-induced intracranial malignant fibrous histiocytoma (fibroxanthosarcoma) is reported. The tumor developed in the region of the sella turcica 11 years after high dose radiotherapy of a chromophobe adenoma of the pituitary. The tumor had infiltrated the base of the brain as well as the base of the skull. Metastases were not found. The tumor was composed of an admixture of bizarre fibroblasts, histiocytes and giant cells, xanthoma cells and siderophages, with a storiform fibrous stroma. This appears to be the first documented instance of a malignant fibrous histiocytoma occurring intracranially after local x irradiation.

• Research Organization: Baltimore City Hospitals
• OSTI ID: 7349017
• Journal Information: Cancer; (United States), Vol. 37:6
• Country of Publication: United States
• Language: English

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DELAYED RADIATION EFFECTS
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SIDE EFFECTS
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ADENOMAS
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560151* - Radiation Effects on Animals- Man