Postirradiation malignant fibrous histiocytoma of the lung. Demonstration of alpha 1-antitrypsin-like material in neoplastic cells

Journal Article · Mon Dec 01 00:00:00 EST 1980 · Am. J. Clin. Pathol.; (United States)

DOI:https://doi.org/10.1093/ajcp/74.6.820· OSTI ID:6042044

Chowdhury, L N; Swerdlow, M A; Jao, W; Kathpalia, S; Desser, R K

A metastasizing fibrous histiocytoma arising in the lung of a patient who received radiation therapy and long-term chemotherapy for malignant lymphoma is presented. Ultrastructural studies revealed fibroblast-like and histiocyte-like cells, cells of intermediate type showing ultrastructural features of both fibroblast-like and histiocyte-like cells, primitive mesenchymal cells, multinucleate tumor cells, and xanthomatous cells. The neoplastic cells showed dilated rough endoplasmic reticula with intracisternal accumulation of electron-dense material forming lattice-like structures. Direct immunofluorescence staining of the neoplastic cells using antihuman alpha 1-antitrypsin showed specific activity, with fluorescent deposits exhibiting interlacing globular formations. These findings and their implications are discussed.

• OSTI ID: 6042044
• Journal Information: Am. J. Clin. Pathol.; (United States), Vol. 74:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
LUNGS
NEOPLASMS
TUMOR CELLS
ULTRASTRUCTURAL CHANGES
CHEMOTHERAPY
FIBROBLASTS
FLUORESCENCE
HISTOLOGY
LYMPHOMAS
MORPHOLOGICAL CHANGES
RADIOTHERAPY
SIDE EFFECTS
ANIMAL CELLS
BODY
CONNECTIVE TISSUE CELLS
DISEASES
LUMINESCENCE
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
RESPIRATORY SYSTEM
SOMATIC CELLS
THERAPY
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)
550900 - Pathology