Metabolic balances of /sup 210/Pb and /sup 210/Po at natural levels
Metabolic balances of /sup 210/Po and /sup 210/Pb were determined under strictly controlled dietary conditions in adult males. The intakes of the two nuclides were due to the dietary contents of these radioisotopes, inhalation from the atmosphere, and smoking of cigarettes. No additional radioisotope was given. The mean dietary intake of /sup 210/Pb was 1.25 pCi/day and of /sup 210/Po, 1.63 pCi/day. The major pathway of excretion of both nuclides is via the gastrointestinal tract and the urinary excretion is much lower. The total excretions of /sup 210/Pb and /sup 210/Po were greater than the dietary intake and the overall balances were -0.28 and -0.16 pCi/day for the two nuclides, respectively, during a low calcium intake. The /sup 210/Pb balances did not change significantly when the calcium intake was increased 7- to 10-fold except for one patient in whom the balance became more negative. The /sup 210/Po balance was more negative during calcium intakes of 800 and 2200 mg than during a low calcium intake of 200 mg/day. The urinary and fecal excretions of the two radionuclides were not affected by the intake of sodium fluoride, while the diuretic compound Hydrodiuril appeared to decrease the fecal /sup 210/Pb excretion.
- Research Organization:
- Veterans Administration Hospital, Hines, IL
- OSTI ID:
- 7327748
- Journal Information:
- Radiat. Res.; (United States), Vol. 69:1
- Country of Publication:
- United States
- Language:
- English
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DIET
BIOLOGICAL EFFECTS
LEAD 210
METABOLISM
POLONIUM 210
TOBACCO SMOKES
EXCRETION
INGESTION
INHALATION
MAN
AEROSOLS
ALPHA DECAY RADIOISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CLEARANCE
COLLOIDS
DAYS LIVING RADIOISOTOPES
DISPERSIONS
EVEN-EVEN NUCLEI
HEAVY NUCLEI
INTAKE
ISOTOPES
LEAD ISOTOPES
MAMMALS
NUCLEI
POLONIUM ISOTOPES
PRIMATES
RADIOISOTOPES
RESIDUES
SMOKES
SOLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)