Radiation-induced erythroleukemia in the beagle dog

Journal Article · Wed Jun 01 00:00:00 EDT 1977 · Am. J. Pathol.; (United States)

OSTI ID:7277931

Tolle, D V; Fritz, T E; Norris, W P

Eleven cases of myeloproliferative disease occurred in a group of 24 beagle dogs placed in a /sup 60/Co ..gamma..-ray field at about 13 months of age and irradiated at an exposure rate of 5 R/22-hour day for duration of life. Of these 11 dogs, 5 were diagnosed as having erythroleukemia. The bone marrow showed marked erythroblastic hyperplasia, with maturation arrest of the erythroid elements, and increased numbers of myeloblasts and promyelocytes. The terminal peripheral blood was characterized by marked anemia and thrombocytopenia, with circulating erythrocytic precursors and abnormal erythrocyte morphology. Splenomegaly and hepatomegaly occurred in 4 of the 5 animals. In the spleens and livers of all 5, there was extensive leukemic infiltration and proliferation. The extent of leukemic involvement in other tissues and organs varied in individual dogs.

• OSTI ID: 7277931
• Journal Information: Am. J. Pathol.; (United States), Vol. 87:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
DOGS
BIOLOGICAL RADIATION EFFECTS
HEMIC DISEASES
ANEMIAS
BIOLOGICAL EFFECTS
BLOOD
BONE MARROW
COBALT 60
ERYTHROCYTES
GAMMA RADIATION
LEUKEMIA
LIVER
MORPHOLOGICAL CHANGES
ORGANS
SPLEEN
TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD CELLS
BODY
BODY FLUIDS
COBALT ISOTOPES
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
GLANDS
HEMATOPOIETIC SYSTEM
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
SYMPTOMS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals
550900 - Pathology