Mathematical model for aerosol deposition in the respiratory tract of the guinea pig
Laboratory animals are used as surrogates in inhalation exposure studies for (1) risk assessments of air pollutants and (2) evaluations of pharmacologic drugs. Herein, a mathematical model is presented that identifies factors affecting the regional distributions of inhaled aerosols within the complete respiratory system of the guinea pig. The model couples empirical and deterministic techniques. An original empirical formula is presented to describe particle losses in airways of the head and throat. Regarding the lung, its structure is defined using the asymmetric morphology of Schreider and Hutchens (1980), and deposition is calculated in a deterministic manner using the protocol of Martonen et al. (1992a, 1992b). Results of our deposition model are compared separately with the theory of Schreider and Hutchens (1979) and the experimental data of Raabe et al. (1988). Results of the deposition model presented herein are in qualitative agreement with the laboratory data of Raabe et al. (1988). Quantitative differences in desposition values may be attributable to different strains of guinea pig being used in the repective morphological and deposition studies. By identifying the factors that most affect the behavior of inhaled particles, our deposition model can aid in the design of inhalation exposure experiments and interpretation of data.
- Research Organization:
- North Carolina Univ., Chapel Hill, NC (United States). Center for Environmental Medicine and Lung Biology
- OSTI ID:
- 7123622
- Report Number(s):
- PB-94-197118/XAB
- Resource Relation:
- Other Information: Pub. in Inhalation Toxicology 6, No. 1, 1-19(Feb 1994)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
54 ENVIRONMENTAL SCIENCES
AEROSOLS
DEPOSITION
MATHEMATICAL MODELS
RESPIRATORY SYSTEM
DRUGS
GUINEA PIGS
MORPHOLOGY
ANIMALS
COLLOIDS
DISPERSIONS
MAMMALS
RODENTS
SOLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
540120 - Environment
Atmospheric- Chemicals Monitoring & Transport- (1990-)