Clearance of sulfuric acid-introduced /sup 35/S from the respiratory tracts of rats, guinea pigs and dogs following inhalation or instillation

Journal Article · · Fundam. Appl. Toxicol.; (United States)

DOI:https://doi.org/10.1016/S0272-0590(83)80142-0· OSTI ID:5774661

Dahl, A R; Felicetti, S A; Muggenburg, B A

The clearance of sulfuric acid-introduced /sup 35/S from the upper and lower respiratory tracts of rats, guinea pigs and dogs was measured. Sulfuric acid was administered by instillation and by inhalation for each species. Clearance into the blood and gastrointestinal tract was measured along with determination of /sup 35/S remaining at the site of administration at sacrifice. Different rates of clearance from different sites within the dog lung were indicated with rates of clearance increasing with decreasing airway diameter. Half-times of clearance from all sites in the lung and for all species were from 2-9 min. There appeared to be some species differences, with clearance for dogs being slower than for guinea pigs, which was slower than for rats. Upper respiratory tract clearance was much slower than for lung and may not have been primarily by way of the blood. The data indicate that the clearance of sulfuric acid-introduced /sup 35/S in vivo is faster than previous studies in isolated perfused lungs had indicated. The results may be general for water soluble, ionized chemical species. 13 references, 3 figures, 1 table.

• Research Organization: Inhalation Toxicology Research Institute, Albuquerque, NM
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 5774661
• Journal Information: Fundam. Appl. Toxicol.; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
SULFURIC ACID
LUNG CLEARANCE
BLOOD
COMPARATIVE EVALUATIONS
DOGS
GASTROINTESTINAL TRACT
GUINEA PIGS
INHALATION
RATS
RESPIRATORY SYSTEM
SULFUR 35
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY FLUIDS
CLEARANCE
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
EVEN-ODD NUCLEI
EXCRETION
HYDROGEN COMPOUNDS
INORGANIC ACIDS
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MATERIALS
NUCLEI
RADIOISOTOPES
RODENTS
SULFUR ISOTOPES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)