A new osmium-191/iridium-191m generator system
Ir-191m (t1/2 4.96 sec) has very attractive properties for radionuclide angiography and is obtained from the long-lived (15 d) 0s-191 parent. Because of the long parent half-life, generators could have an extended shelf-life (2-3 weeks) if the problems of low Ir-191m yields and rapidly increasing Os-191 breakthrough could be overcome. A new /sup 191/Os//sup 191m/Ir generator system has now been developed involving adsorption of K/sub 2/OsCl/sub 6/ (0s-IV) on heat-treated (800/sup 0/C) activated coconut carbon. This system gives consistently good Ir-191m yields of approx. =35-40% for a 5 ml bolus and low Os-191 breakthrough of approx. =1x10/sup -4/% bolus over a 2-3 week period. In addition, this simple system does not require a scavenger column and no radiolysis has been detected after loading up to 1 Ci of Os-191. The generator is prepared from 140-230 mesh carbon and eluted with pH 2 - 0.9% NaCl containing 0.025% KI. The use of KI in the eluting solution is critical for generator performance. Yield and breakthrough do not change for up to 250 elutions of the prototype system. The generator eluent is neutralized to physiological pH and isotonicity with 0.13 M Tris buffer immediately prior to intravenous injection. No adverse effects have been observed in studies in normal adult volunteers. This system has a long shelf-life and represents a simple, readily available source of Ir-191m for radionuclide angiography.
- Research Organization:
- Nuclear Medicine Group, Oak Ridge National Lab., Oak Ridge, TN
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6855640
- Report Number(s):
- CONF-850611-; TRN: 87-010699
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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A new /sup 191/Os//sup 191m/Ir generator system for medical use
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
IRIDIUM 191
RADIOISOTOPE GENERATORS
YIELDS
DESIGN
ACTIVATED CARBON
OSMIUM 191
PH VALUE
POTASSIUM IODIDES
ADSORBENTS
ALKALI METAL COMPOUNDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBON
DAYS LIVING RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
HALIDES
HALOGEN COMPOUNDS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INORGANIC PHOSPHORS
IODIDES
IODINE COMPOUNDS
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
OSMIUM ISOTOPES
PHOSPHORS
POTASSIUM COMPOUNDS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production