A new /sup 191/Os//sup 191m/Ir generator system for medical use
The use of ultra-short lived single photon emitting radionuclides for angiography offers several advantages including the opportunity to perform rapid repeat studies and a significantly reduced radiation exposure to both patient and personnel. Considering the physical characteristics of the /sup 191/Os//sup 191/Ir radionuclide pair, a generator system based on this parent-daughter pair presents additional specific advantages. /sup 191m/Ir decays by isomeric transition with a half life of 4.96 sec emitting x-rays and gamma photons, which are compatible with conventional gamma cameras. The short half life of /sup 191m/Ir minimizes the absorbed dose by the patient and permits the injection of a bolus every 30 sec. The /sup 191/Os parent decays by ..beta../sup /minus// emission with a half life of 15.4 days emitting no gamma photons. The long half life of the /sup 191/Os parent makes the useful shelf life of the generator several weeks. A new /sup 191/Os//sup 191m/Ir radionuclide generator system which utilizes a heat-treated activated carbon adsorbent has been developed. In the present paper, the preparation, the characteristics, and the use conditions of this generator are described. 4 refs., 2 figs., 1 tab.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6881267
- Report Number(s):
- CONF-8801130-1; ON: DE89004177
- Resource Relation:
- Conference: 18. international symposium on radioactive isopopes in clinical medicine and research, Badgastein, Austria, 11 Jan 1988; Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
RADIATION DOSES
MINIMIZATION
RADIOPHARMACEUTICALS
PRODUCTION
GAMMA CAMERAS
IRIDIUM 191
OSMIUM 191
RADIOISOTOPE GENERATORS
USES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
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DAYS LIVING RADIOISOTOPES
DOSES
DRUGS
EVEN-ODD NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
OSMIUM ISOTOPES
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES
400703* - Radiochemistry & Nuclear Chemistry- Radioisotope Production
560160 - Radionuclide Effects
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& Toxicology