Thermal responses to 5. 6-GHz radiofrequency radiation in anesthetized rats. Effect of chlorpromazine
Anesthetized rats were exposed to 5.6-GHz continuous-wave radiofrequency radiation (RFR) at an average power density of 60 mW/Sq. cm (average specific absorption rate 12 W/kg). Exposure was performed to raise colonic temperature from 38.5 to 39.5C. Following acute administration of chlorpromazine, body temperature exhibited a faster return to baseline temperature when exposure was discontinued. When exposure was initiated at 38.5C and continued until lethal temperature resulted, chlorpromazine-treated animals exhibited significantly shorter survival times than saline-treated animals. Thus, although chlorpromazine enhanced thermoregulatory efficiency at colonic temperature below 39.5 deg C, the drug caused increased susceptibility to terminal RFR. The present results, when compared with previous studies of irradiation at 2.8 GHz, indicate that the effects of chlorpromazine on thermal response to RFR during intermittent and terminal exposure are similar at both 2.8 and 5.6 GHz.
- Research Organization:
- School of Aerospace Medicine, Brooks AFB, TX (USA)
- OSTI ID:
- 6784763
- Report Number(s):
- AD-A-200538/7/XAB; USAFSAM-JA-87-55
- Resource Relation:
- Other Information: Pub. in Physiological Chemistry and Physics and Medical NMR, Vol. 20, 135-143(1988)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHLORPROMAZINE
RADIOSENSITIVITY EFFECTS
RADIOWAVE RADIATION
BIOLOGICAL RADIATION EFFECTS
RATS
BODY TEMPERATURE
IRRADIATION
TEMPERATURE CONTROL
AMINES
ANIMALS
AZINES
BIOLOGICAL EFFECTS
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CONTROL
DRUGS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHENOTHIAZINES
PSYCHOTROPIC DRUGS
RADIATION EFFECTS
RADIATIONS
RODENTS
TRANQUILIZERS
VERTEBRATES
560400* - Other Environmental Pollutant Effects