High sensitivity localization of parathyroid tumors by nuclear imaging in 50 proven cases
Fifty patients with surgically and biochemically proven hyperparathyroidism had imaging studies of the neck performed with Thallium-201 chloride (2-3mCi) and Tc-99m pertechnetate, a gamma camera and pinhole collimator, and acquired and processed with a DEC PDP-11 computer with color coding for differences in localization of Tl-201 (in thyroid and parathyroid tumor) compared with pertechnetate (in the thyroid alone). Thirty-eight of 43 single parathyroid adenomas (88%) were successfully localized, 6 of 9 multiple adenomas in 3 such patients, and 11 of 12 hyperplastic glands in 3 patients with secondary hyperparathyroidism, and 1 of 1 with cancer. With regard to tumor size, 92% of tumors 1.0 cm. or larger were found, but only 50% of those smaller than 0.7 cm. One substernal adenoma 0.6 cm. in size was missed, but 5 of 6 adenomas previously missed at surgery were found successfully. No normal or functionally suppressed glands were identified, and no false positive studies were seen, even in patients with abnormal thyroid glands. Nuclear imaging studies with computerized comparison are the most efficacious single method for preoperative localization of parathyroid tumors yet reported, and distinguish single versus multiple disease with high reliability. All 3 intrathyroid parathyroid adenomas were identified as to site with this method. Advantages of preoperative localization of parathyroid tumors include planning of surgical approach, shortening of operations, and localization of thyroidotomy for intrathyroid tumors.
- Research Organization:
- Univ. of California Medical Center, San Francisco, CA
- OSTI ID:
- 6574823
- Report Number(s):
- CONF-840619-; TRN: 87-018940
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ADENOMAS
CAT SCANNING
SCINTISCANNING
DUAL-ISOTOPE SUBTRACTION TECHNIQUE
IMAGE PROCESSING
PARATHYROID GLANDS
COLLIMATORS
COMPUTERIZED TOMOGRAPHY
DATA PROCESSING
GAMMA CAMERAS
MORPHOLOGY
NECK
NEOPLASMS
PDP COMPUTERS
RADIOPHARMACEUTICALS
TECHNETIUM 99
THALLIUM 201
THALLIUM CHLORIDES
TISSUE DISTRIBUTION
UPTAKE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
CAMERAS
CHLORIDES
CHLORINE COMPOUNDS
COMPUTERS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DEC COMPUTERS
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
HALIDES
HALOGEN COMPOUNDS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PROCESSING
RADIOISOTOPE SCANNING
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
TECHNETIUM ISOTOPES
THALLIUM COMPOUNDS
THALLIUM HALIDES
THALLIUM ISOTOPES
TOMOGRAPHY
TRACER TECHNIQUES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics